Foto del docente

Sabrina Angelini

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/14 Pharmacology


Keywords: Pharmacogenetics Biomarkers Genetic polymorphisms micrRNA

1] Pharmacogenetic studies; 

2]  biomarkers of effect and susceptibility in population exposed to pollutants;

3] Epidemiological studies in population exposed to ionizing radiation.

The work is carried out in 3 major areas of interest: pharmacogenetics, molecular biology-mutations and toxicology. 

Pharmacogenetics –Specific aims of this research - area is to correlate genetic polymorphisms (SNPs) in key genes to drug efficacy. In particular the interest is focused on the analysis of SNPs in genes coding for specific drug- metabolising and transporters enzymes. In the long run, this may enable to identify one or, most probably, a subset of SNPs with predictive value allowing to optimise the therapeutic use of drugs. 

Molecular biology-mutations - The aim is to identify genes that underlie cancer susceptibility. A major effort has been directed to analysis of polymorphisms (SNPs) in cancer-related genes. For this purpose case-control studies have been carried out on many cancer, including breast cancer. Moreover, the role of BRAF and RAS has been elucidated in melanoma and other neoplasm. 

Toxicology - the research activities involve the identification of environment-related risk factors and studies on interactions of carcinogenic agents with acquired or inherited host factors (genetic predisposition) in human cancers. Special emphasis is given to explore cellular and molecular mechanism of mutagenesis and cancerogenesis by applying the tools of cytogenetic and molecular biology to humans. An important field of research is the development of new biomarkers for the detection of DNA-damage and of biomarkers for cancer susceptibility which are to be used in cancer epidemiology, intervention and clinical trials. Special emphasis is also given to studies in molecular epidemiology, specifically to characterize the relevance of new genetic polymorphisms, to explore further susceptibility genes of cancer, to identify risk groups in the population for prevention and screening and to further add to our understanding of gene - environment interactions. Biomarkers have been successfully employed in studies designed to assess genetic damage induced by professional exposure to ionizing radiation and urban air pollution.