Formica S.;Astolfi A.;Roncaglia E.;Tagliafico E.;Tonelli R.;Pession A., valutazione preclinica della terapia epigenetica con inibitori delle iston-deacetilasi ( acido valproico) e dna-metiltransferasi ( decitabina ) in leucemie mieloidi acute con riarrangiamenti di MLL, in: , «HAEMATOLOGICA», 2006, 91 supplement no.4, pp. 111 - 112 (atti di: XXXIII Congresso Nazionale Associazione Italiana Ematologia Oncologia Pediatrica, Abano -Terme, 22-24 ottobre 2006) [Abstract]
TONELLI R; PURGATO S; CAMERIN C; FRONZA R; BOLOGNA F; ALBORESI S; FRANZONI M; CORRADINI R; SFORZA S; FACCINI A; SHOHET JM; MARCHELLI R; PESSION A., Anti-gene Peptide Nucleic Acid (PNA) specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis., «MOLECULAR CANCER THERAPEUTICS», 2005, 4, pp. 779 - 786 [Scientific article]
Quentmeier H; Tonelli R; Geffers R; Pession A; Uphoff CC; Drexler HG., Expression of BEX1 in acute myeloid leukemia with MLL rearrangements, «LEUKEMIA», 2005, 19, pp. 1488 - 1489 [Scientific article]
Croci S; Strippoli P; Bonsi L; Bagnara GP; Guizzunti G; Sartini R; Tonelli R; Messina C; Pierdomenico L; Lollini PL., Expression of T cell receptor alpha gene (TCRA) in human rhabdomyosarcoma and other musculo-skeletal sarcomas., «GENE», 2005, 353, pp. 16 - 22 [Scientific article]
Tonelli R., Sartini R., Fronza R., Freccero F, Franzoni M., Dongiovanni D., Ballarini M., Ferrari S., D’Apolito M., Di Cola G., Capranico G., Khobta A., Campanini R., Paolucci P., Minucci S., Pession, A., G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent, «BLOOD», 2005, 106, pp. 4410 - 4410 [Abstract]
P. Rocchi; R. Tonelli; C.Camerin; S.Purgato; R.Fronza; F.Bianucci; F.Guerra; A.Pession; AM.Ferreri, p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells, «ONCOLOGY REPORTS», 2005, 13, pp. 1139 - 1144 [Scientific article]
PESSION A.; TONELLI R, The MYCN oncogene as a specific and selective drug target for peripheral and central nervous system tumors., «CURRENT CANCER DRUG TARGETS», 2005, 5, pp. 273 - 283 [Scientific article]
SLACK A; CHEN Z; TONELLI R; PULE M; HUNT L; PESSION A.; SHOHET JM, THE P53 REGULATORY GENE MDM2 IS A DIRECT TRANSCRIPTIONAL TARGET OF MYCN IN NEUROBLASTOMA, «PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA», 2005, 102, pp. 731 - 736 [Scientific article]
MONTAGNA D; SCHIAVO R; GIBELLI N; PEDRAZZOLI P; TONELLI R; PAGANI S; ASSIRELLI E; LOCATELLI F; PESSION A.; FREGONI V; MONTINI E; DA PRADA GA; SIENA S; MACCARIO R, EX VIVO GENERATION AND EXPANSION OF ANTI-TUMOR CYTOTOXIC T-CELL LINES DERIVED FROM PATIENTS OR THEIR HLA-IDENTICAL SIBLING, «INTERNATIONAL JOURNAL OF CANCER», 2004, 110, pp. 76 - 86 [Scientific article]
Montemurro L.;Tonelli R.;Fazzina R.;Martino V.;Marino F.;Pession A., Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line., «CANCER GENETICS AND CYTOGENETICS», 2004, 154, pp. 96 - 97 [Scientific article]
Patent n. WO2004096826
Classification:
- international: C07H21/00
- european: C12N15/11B2, METHOD FOR SELECTIVE INHIBITION OF HUMAN N-MYC GENE IN N-MYC EXPRESSING TUMORS THROUGH ANTISENSE AND ANTIGEN PEPTIDO-NUCLEIC ACIDS (PNA).
PESSION A; TONELLI R; FRONZA R; SCIAMANNA E; CORRADINI R; SFORZA S; TEDESCHI T; MARCHELLI R; MONTANARO L.; CAMERIN C; FRANZONI M; PAOLUCCI G, Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis, «INTERNATIONAL JOURNAL OF ONCOLOGY», 2004, 24, pp. 265 - 272 [Scientific article]
Pession A.; Martino V.; Tonelli R.; Beltramini C.; Locatelli F.; Biserni G.; Franzoni M.; Freccero F.; Montemurro L.; Pattacini L.; Paolucci G., MLL-AF9 oncogene expression affects cell growth but not terminal differentiation and is downregulated during monocyte-macrophage maturation in AML-M5 THP-1 cells, «ONCOGENE», 2003, 22, pp. 8671 - 8676 [Scientific article]
