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Pier Paolo Piccaluga

Associate Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Academic discipline: MED/08 Pathology

Research

PERIPHERAL T-CELL LYMPHOMAS (PTCL): MOLECULAR CHARACTERISATION AND DEVELOPMENT OF INNOVATIVE THERAPIES

Identification of the main genomic alterations that concur to the development of the commonest varieties of PTCL including the not otherwise specified (PTCL/NOS), angioimmunoblastic (AITL) and anaplastic large cell (ALCL) ones. Attention will be focused on the mechanisms of PDGFRalpha gene over-expression and cell cycle deregulation (with special reference to PTEN, NF-kappaB and p27).

Identification of genomic and proteomic profiles of these tumours, potentially provided with diagnostic and prognostic impact. In particular, the research activity will explore ALCL that is the third commonest PTCL histotype following PTCL/NOS and AITL, which have been the object of previous studies.

Development of innovative tailored therapies based on the pathobiology of PTCL by adopting different approaches including the mouse model.

Pharmaco-genomic experimental studies.

 

PERIPHERAL B-CELL LYMPHOMAS: MOLECULAR CHARACTERISATION AND DEVELOPMENT OF INNOVATIVE THERAPIES

Development of markers specific of nodal marginal zone B-cell lymphoma, lacking at the moment. The latter situation leads to a diagnosis by exclusion and not by identification, a fact that is limitative in terms of therapeutic startaegies.

Analysis of the somatic mutations, DNA copy number variations, gene expression profile, miRNA profile and CpG methylation in diffuse large B-cell lymphoma, Burkitt lymphoma, mantle-cell lymphoma and grade 3 follicular lymphoma. The obtained data will be validated by immunohistochemistry on tissue micro-arrays and chromatic precipitation.

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