1) Definition of the full spectrum of clinico-pathological
phenotypes in human prion disease focusing on
the identification and characterization of novel rare
phenotypes
2) Study of the epidemiology of Creutzfeldt-Jakob in Italy
through the molecular and pathological analysis of clusters
3) Development of new assays for the sensitive and specific
diagnostic detection and strain typing of Creutzfeldt-Jakob
disease
4) Study of the molecular basis of strain variation in
human prion disease through the characterization of the
physico-chemical properties of PrPSc
5) Definition and validation of new diagnostic protocols for the
post-mortem diagnosis of neurodegenerative diseases
