Foto del docente

Paola Franchi

Associate Professor

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/06 Organic Chemistry

Research

Keywords: ESR Spectroscopy Rotaxane Free Radicals Supramolecular Chemistry Nanostructures EPR Spectroscopy

Investigation of paramagnetic supramolecular systems (host-guest) in aqueous and organic solutions. To this aim were developed:

 

1) Different methods and radical probes (guest) to use EPR (spectroscopy of paramagnetic electronic resonance) to investigate the properties of host systems such as cyclodextrins, cucurbiturils, calyxarenes, micelles and gold nanoparticles. In particular were determined the stability constants and the association and dissociation rate constants of supramolecular complexes, that hold together by weak interactions, include hydrogen bonding, van der Waals and hydrophobic forces, not easily accessible by using other techniques.

 

2) Different synthetic strategy for the preparation of auto-assembled systems, in which the radical guest is mechanical interlocked inside the host molecule. We are interested to prepare a relatively new class of molecular architectures denominated Rotaxanes, in which a cyclic component (bead) is threaded by a linear chain (thread) trapped by bulky groups (stoppers) at one ([1]rotaxane) or at both ([2]rotaxane) termini of the thread. In particular we use stoppers like paramagnetic TEMPO derivatives. The prepared structures were characterized by using 1D and 2D NMR, ESI-MS, and EPR.

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