Foto del docente

Michele Protti

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHEM-07/A Pharmaceutical Chemistry

Research

Keywords: Analytical method development Microsampling Miniaturised sample pretreatment Biological and non-biological matrices Analysis of drugs of abuse Analysis of new psychoactive substances (NPS) Analysis of CNS drugs Analysis of doping agents Pharmacokinetics analysis Stability analysis Toxicological analysis Metabolomics analysis Medicinal chemistry Mass spectrometry (MS, MS/MS, HRMS) HPLC Analytical method validation

Development of innovative strategies for the analysis of bioactive substances.

Development, validation and application of original methods for the quali-quantitative analysis of classical drugs of abuse, new synthetic compounds, doping agents, CNS drugs, metabolites and markers in biological and non-biological samples.

Development of advanced instrumental methods based on high-performance liquid chromatography coupled to several detection means (LC-MS, LC-MS/MS, HPLC-UV/DAD, HPLC-F, HPLC-ED).

Development, optimization and validation of innovative miniaturized sampling and pretreatment procedures for biological and non-biological samples.

Therapeutic drug monitoring (TDM) of CNS drugs: antipsychotics, antidepressants, antiepileptic and sedative-hypnotics.

Analysis of bioactive compounds in natural matrices, food supplements and herbal products.