Foto del docente

Michela Rosini

Professoressa associata

Dipartimento di Farmacia e Biotecnologie

Settore scientifico disciplinare: CHIM/08 CHIMICA FARMACEUTICA

Pubblicazioni

MARUCCI G.; NOVI F.; BANZI R.; BOLOGNESI M. L.; BUCCIONI M.; MINARINI A.; ROSINI M.; ANGELI P.; MAGGIO R.; MELCHIORRE C., Polyamines may modulate both G protein-coupled receptors and G proteins, «MEDICINAL CHEMISTRY RESEARCH», 2004, 13, pp. 63 - 73 [articolo]

Tumiatti V.; Bolognesi M.L.; Minarini A.; Rosini M.; Angeli A.; Buccioni M.; Marucci G.; Melchiorre C., Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici, in: Atti del Convegno, PISA, Grafiche Caroti, 2004(atti di: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della SCI, Pisa, 5-9 Settembre 2004) [atti di convegno-abstract]

TUMIATTI V.; ANDRISANO V.; BANZI R.; BARTOLINI M.; MINARINI A.; ROSINI M.; MELCHIORRE C., Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties, «JOURNAL OF MEDICINAL CHEMISTRY», 2004, 47, pp. 6490 - 6498 [articolo]

Melchiorre C.; Antonello A.; Banzi R.; Bolognesi M.L.; Minarini A.; Rosini M.; Tumiatti V., Polymethylene tetraamine backbone as template for the development of biologically active polyamines, «MEDICINAL RESEARCH REVIEWS», 2003, 23, pp. 200 - 233 [articolo]

Rosini M.; Bixel M.G.; Marucci G.; Budriesi R.; Krauss M.; Bolognesi M.L.; Minarini A.; Tumiatti V.; Hucho F.; Melchiorre C., Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms, «JOURNAL OF MEDICINAL CHEMISTRY», 2002, 45, pp. 1860 - 1878 [articolo]

Bolognesi M.L.; Bixel M.G.; Marucci G.; Bartolini M.; Krauss M.; Angeli P.; Antonello A.; Rosini M.; Tumiatti V.; Hucho F.; Melchiorre C., Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure, «JOURNAL OF MEDICINAL CHEMISTRY», 2002, 45, pp. 3286 - 3295 [articolo]

Bolognesi M.L.; Marucci G.; Angeli P.; Buccioni M.; Minarini A.; Rosini M.; Tumiatti V.; Melchiorre C., Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward α1-adrenoreceptor subtypes, «JOURNAL OF MEDICINAL CHEMISTRY», 2001, 44, pp. 362 - 371 [articolo]

Budriesi R.; Cacciaguerra S.; Di Toro R.; Bolognesi M.L.; Chiarini A.; Minarini A.; Rosini M.; Spampinato S.; Tumiatti V.; Melchiorre C., Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines, «BRITISH JOURNAL OF PHARMACOLOGY», 2001, 132, pp. 1009 - 1016 [articolo]Open Access

Bixel M.Gabriele; Krauss M.; Weise C.; Bolognesi M.L.; Rosini M.; Usherwood P.N.R.; Melchiorre C.; Hucho F., Binding of polyamine-containing toxins in the vestibule of the nicotinic acetylcholine receptor ion channel, «IL FARMACO», 2001, 56, pp. 133 - 135 [articolo]

Melchiorre C.; Bolognesi M.L.; Budriesi R.; Ghelardini C.; Chiarini A.; Minarini A.; Rosini M.; Tumiatti V.; Wade E.J., Design, synthesis, and biological activity of methoctramine-related polyamines as putative Gi protein activators, «JOURNAL OF MEDICINAL CHEMISTRY», 2001, 44, pp. 4035 - 4038 [articolo]

Bixel M.G.; Weise C.; Bolognesi M.L.; Rosini M.; Brierly M.J.; Mellor I.R.; Usherwood P.N.R.; Melchiorre C.; Hucho F., Location of the Polyamine Binding Site in the Vestibule of the Nicotinic Acetylcholine Receptor Ion Channel, «THE JOURNAL OF BIOLOGICAL CHEMISTRY», 2001, 276, pp. 6151 - 6160 [articolo]

Bixel M.G.; Krauss M.; Liu Y.; Bolognesi M.L.; Rosini M.; Mellor I.S.; Usherwood P.N.R.; Melchiorre C.; Koji N.; Hucho F., Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor, «EUROPEAN JOURNAL OF BIOCHEMISTRY», 2000, 267, pp. 110 - 120 [articolo]

Melchiorre C.; Angeli P.; Bolognesi M.L.; Chiarini A.; Giardina D.; Gulini U.; Leonardi A.; Marucci G.; Minarini A.; Pigini M.; Quaglia W.; Rosini M.; Tumiatti V., α1-Adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety, «PHARMACEUTICA ACTA HELVETIAE», 2000, 74, pp. 181 - 190 [articolo]

Rosini M.; Budriesi R.; Bixel M.G.; Bolognesi M.L.; Chiarini A.; Hucho F.; Krogsgaard-Larsen P.; Mellor I.R.; Minarini A.; Tumiatti V.; Usherwood P.N.R.; Melchiorre C., Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists, «JOURNAL OF MEDICINAL CHEMISTRY», 1999, 42, pp. 5212 - 5223 [articolo]

Bolognesi M.L.; Budriesi R.; Cavalli A.; Chiarini A.; Gotti R.; Leonardi A.; Minarini A.; Poggesi E.; Recanatini M.; Rosini M.; Tumiatti V.; Melchiorre C., WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for α1-adrenoreceptor subtypes and 5-HT(1A) receptors, «JOURNAL OF MEDICINAL CHEMISTRY», 1999, 42, pp. 4214 - 4224 [articolo]