Spinopelvic sagittal alignment in healthy subjects
Study of the physiological sagittal alignment of spine and spinopelvic complex in adolescents and young healthy subjects, with particular focus on the relationships among pelvic incidence (PI), sacral slope (SS), and the global spinal sagittal alignment. This research area includes the analysis of the possible changes in PI during growth, the definition of “normal spinopelvic alignment,” and the development of predictive models of the “ideal” spinal alignment based on pelvic morphological parameters.
Preoperative surgical planning in idiopathic spinal deformities (AIS, YAdIS, AdIS)
Study of personalized preoperative planning in idiopathic deformities of adolescents, young adults, and adults, with particular attention to the restoration of physiological sagittal alignment and the assessment of proximal and distal compensatory mechanisms. This area includes studies on the classification of adult idiopathic scoliosis and on postoperative changes in cranial and caudal compensatory mechanisms following corrective surgery for adolescent spinal deformities.
Preclinical and translational studies on the major spinal disorders
Research activity focused on the biological, molecular, and systemic mechanisms involved in spinal disorders and in their surgical outcomes. It includes studies on osteosarcopenia and frailty as risk factors for mechanical failure and infection, intervertebral disc mechanobiology, epigenetic regulation of idiopathic scoliosis progression, and the identification of circulating, cellular, and tissue biomarkers.
Ewing sarcoma
Study of prognostic and predictive factors in Ewing sarcoma through the integration of clinical, radiological, and laboratory parameters. This research line includes the analysis of the role of serum inflammatory biomarkers, radiological response to neoadjuvant chemotherapy, and the impact of preoperative radiotherapy on histological and oncological outcomes.
