Foto del docente

Maria Laura Bolognesi

Full Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Coordinator of PhD Programme in Biotechnological, Biocomputational, Pharmaceutical and Pharmacological Sciences

Publications

A.Cavalli; ML Bolognesi; M.Bartolini; V.Andrisano; C.Melchiorre; M.Recanatini; S.Capsoni; A.Cattaneo, MEMOQUIN: A MULTIPOTENT ACETYLCHOLINESTERASE INHIBITOR WITH EXCELLENT IN VIVO ACTIVITY, in: VIII International Meeeting on Cholinesterase, Abstract book, PERUGIA, s.n, 2004, 1, pp. 11 - 11 (atti di: VIII International Meeeting on Cholinesterase, Perugia, 26-30 settembre 2004) [Abstract]

Cavalli A.; Bolognesi M.L.; Bartolini M.; Andrisano V.; Melchiorre C.; Recanatini M.; Capsoni S.; Cattaneo A., Memoquin: a new compound to attack Alzheimer's disease drug discovery, in: Abstract book, MONTREAL, s.l., 2004(atti di: 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy, Montreal, 14-17 April 2004) [Abstract]

Cavalli A.; Bolognesi M.L.; Bartolini M.; Andrisano V.; Melchiorre C.; Recanatini M.; Margotti E.; Capsoni S.; Cattaneo A., Memoquin: a new therapeutic poly-agent for Alzheimer's disease, in: , «NEUROBIOLOGY OF AGING», 2004, 25, pp. S194 - S194 (atti di: The 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, Pennsylvania, U.S.A., 17-22 Luglio 2004) [Abstract]

MARUCCI G.; NOVI F.; BANZI R.; BOLOGNESI M. L.; BUCCIONI M.; MINARINI A.; ROSINI M.; ANGELI P.; MAGGIO R.; MELCHIORRE C., Polyamines may modulate both G protein-coupled receptors and G proteins, «MEDICINAL CHEMISTRY RESEARCH», 2004, 13, pp. 63 - 73 [Scientific article]

Tumiatti V.; Bolognesi M.L.; Minarini A.; Rosini M.; Angeli A.; Buccioni M.; Marucci G.; Melchiorre C., Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici, in: Atti del Convegno, PISA, Grafiche Caroti, 2004(atti di: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della SCI, Pisa, 5-9 Settembre 2004) [Abstract]

Melchiorre C.; Antonello A.; Banzi R.; Bolognesi M.L.; Minarini A.; Rosini M.; Tumiatti V., Polymethylene tetraamine backbone as template for the development of biologically active polyamines, «MEDICINAL RESEARCH REVIEWS», 2003, 23, pp. 200 - 233 [Scientific article]

Rosini M.; Bixel M.G.; Marucci G.; Budriesi R.; Krauss M.; Bolognesi M.L.; Minarini A.; Tumiatti V.; Hucho F.; Melchiorre C., Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms, «JOURNAL OF MEDICINAL CHEMISTRY», 2002, 45, pp. 1860 - 1878 [Scientific article]

Bolognesi M.L.; Bixel M.G.; Marucci G.; Bartolini M.; Krauss M.; Angeli P.; Antonello A.; Rosini M.; Tumiatti V.; Hucho F.; Melchiorre C., Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure, «JOURNAL OF MEDICINAL CHEMISTRY», 2002, 45, pp. 3286 - 3295 [Scientific article]

Bolognesi M.L.; Marucci G.; Angeli P.; Buccioni M.; Minarini A.; Rosini M.; Tumiatti V.; Melchiorre C., Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward α1-adrenoreceptor subtypes, «JOURNAL OF MEDICINAL CHEMISTRY», 2001, 44, pp. 362 - 371 [Scientific article]

Budriesi R.; Cacciaguerra S.; Di Toro R.; Bolognesi M.L.; Chiarini A.; Minarini A.; Rosini M.; Spampinato S.; Tumiatti V.; Melchiorre C., Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines, «BRITISH JOURNAL OF PHARMACOLOGY», 2001, 132, pp. 1009 - 1016 [Scientific article]Open Access

Bixel M.Gabriele; Krauss M.; Weise C.; Bolognesi M.L.; Rosini M.; Usherwood P.N.R.; Melchiorre C.; Hucho F., Binding of polyamine-containing toxins in the vestibule of the nicotinic acetylcholine receptor ion channel, «IL FARMACO», 2001, 56, pp. 133 - 135 [Scientific article]

Melchiorre C.; Bolognesi M.L.; Budriesi R.; Ghelardini C.; Chiarini A.; Minarini A.; Rosini M.; Tumiatti V.; Wade E.J., Design, synthesis, and biological activity of methoctramine-related polyamines as putative Gi protein activators, «JOURNAL OF MEDICINAL CHEMISTRY», 2001, 44, pp. 4035 - 4038 [Scientific article]

Bixel M.G.; Weise C.; Bolognesi M.L.; Rosini M.; Brierly M.J.; Mellor I.R.; Usherwood P.N.R.; Melchiorre C.; Hucho F., Location of the Polyamine Binding Site in the Vestibule of the Nicotinic Acetylcholine Receptor Ion Channel, «THE JOURNAL OF BIOLOGICAL CHEMISTRY», 2001, 276, pp. 6151 - 6160 [Scientific article]

D'Agostino G.; Bolognesi M.L.; Lucchelli A.; Vicini D.; Balestra B.; Spelta V.; Melchiorre C.; Tonini M., Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: Involvement of the M4 receptor subtype, «BRITISH JOURNAL OF PHARMACOLOGY», 2000, 129, pp. 493 - 500 [Scientific article]

Bixel M.G.; Krauss M.; Liu Y.; Bolognesi M.L.; Rosini M.; Mellor I.S.; Usherwood P.N.R.; Melchiorre C.; Koji N.; Hucho F., Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor, «EUROPEAN JOURNAL OF BIOCHEMISTRY», 2000, 267, pp. 110 - 120 [Scientific article]