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Mariacristina Di Marco

Assistant professor

Department of Medical and Surgical Sciences

Academic discipline: MED/06 Medical Oncology

Research

Keywords: intestinal microbiote GIST pancreatic cancer gene expression immune system hepatocellular carcinoma asbestos in CC hENT1 and related enzyme for gemcitabine liver metastases intestinal microflora antiangiogenic therapies cholangiocarcinoma NGS analysis of pre-neoplastic and neoplastic pancreatic lesions stem cells

  • Genetic analysis through next generation sequencing of pancreatic neoplastic and pre-neoplastic lesions
  • Isolation and identification of cancer stem cells in fresh tissue of surgically resected pancreatic adenocarcinoma patients.
  • Isolation and identification of cancer stem cells in fresh tissue of surgically resected cholangiocarcinoma patients.
  • Role of protease inhibitors on colon adenocarcinoma cell lines non responding EGFR blocking therapies (KRAS, BRAF, PI3K mutated)
  • Role of protease inhibitors on triple negative breast cancer cell lines  
  • Experimental treatment of hepatocarcinoma with metronomic capecitabine.
  • Experimental treatment of hepatocarcinoma relapse after orthotopic liver transplantation.
  • Experimental study on pancreatic adenocarcinoma cell lines of the comination of standard agents plus gabesate mesylate (a pancreatic protease inhibitor) to increase chemotherapy efficacy..
  • Experimental evaluation of transglutaminase-2 expression in pancreatic adenocarcinoma cell lines.
  • Asbestos role in the development of  cholangiocarcinoma: perspective case-control study CARA.
  • Asbestos etiopathogenic role in development of  cholangiocarcinoma: whole transcriptome expression analisys of intrahepatic cholangiocarcinomas.  
  • Molecular factors predicting adiuvant chemotherapy response in patients with cholangiocarcinoma (hENT and other enzymes).
  • Molecular factors predicting chemotherapy response in patients with pancreatic cancer (hENT).    
  • Experimental study of intestinal bacterial flora role on antiblastics toxicity.
  • Experimental study of intestinal microbiote on colon cancer origin.

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