Personal details
Name and Surname: Manuela Mancini
Birth date: July 8th, 1978
Place of Birth: Messina
Nationality: Italian
Telephone Number: mobile: +39-339-5008394
E-mail: mancini_manu@yahoo.com [mailto:mancini_manu@yahoo.com], manuela.mancini6@unibo.it [mailto:manuela.mancini6@unibo.it], mancini.manuela@aosp.bo.it
Orcid: 0000-0002-2972-5609
PRESENT POSITION
Health Researcher, IRCCS Azienda Ospedaliero-Universitaria di Bologna
Supervisor: Prof. Michele Cavo.
Affiliation
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
EDUCATION
- December 2010: Post Graduation Degree in Clinical Biochemistry. University of Modena and Reggio Emilia, Italy. 110/110 cum laude. Thesis title: “Fighting leukemic stem cells: the new challenge in targeted therapy of Chronic Myeloid Leukemia” Supervisor: Prof. Maria Alessandra Santucci.
- May 2005: PhD in “Molecular and Cellular Biotechnology”. Thesis title: “P210 BCR-ABL tyrosine kinase prevents apoptotic cell death through multiple pathways converging at mitochondrial membranes”, University of Bologna, Italy. Supervisor: Prof. Rita Casadio.
- July 2001: Graduation Degree in Biotechnology, University of Bologna, Italy. 110/110. Thesis title: “Biomolecular pathways involved in abrogation of G1/S and G2/M checkpoints associated with BCR-ABL expression in Chronic myeloid leukemia”. Supervisor: Prof. Maria Alessandra Santucci.
FOREIGN LANGUAGE
RESEARCH FOCUS AND EXPERTISE:
Chronic Myeloid Leukemia; Systemic Mastocytosis; molecular and cellular mechanisms of resistance to targeted therapies.
MEMBERSHIP OF SCIENTIFIC ASSOCIATIONS•
Member of the Italian Society of Experimental Hematology (SIES), the European Hematology Association (EHA).
PARTICIPATION IN national research projects funded on A COMPETITIVE basis
- ·•Scientific collaborator of a 2019 IG Grant of the Italian Association for Cancer Research (AIRC): “ReSETting SETD2/H3K36Me3 deficiency in advanced systemic mastocytosis and chronic myeloid leukemia” (Project Id.23001)
- Co-Principal Investigator of the project funded by Ministry of Health:"BCR-ABL MUTATION INDEPENDENT MECHANISMS INVOLVED IN RESISTANCE TO TYROSINE KINASE INHIBITORS IN CHRONIC MYELOID LEUKEMIA", (Project Id.GR-2016-02364880)
- ·•Scientific collaborator of a 2015 AIRC IG Grant: “High throughput technologies for improved diagnosis, molecular profiling and therapy of systemic mastocytosis” (Project Id.16996)
COLLABORATION IN JOURNAL EDITORIAL BOARDS
Guest Editor of:
Special Issue: “CML HSCs: are the true enemies for the patient?” Current Drug Targets 2017 IF:3.465
REVIEWER ACTIVITY
Manuscript reviewer for international journals (BMC cancer, Leukemia research, Scientific Reports, PlosOne, The European Journal of Pharmacology)
PARTICIPATION IN NATIONAL AND INTERNATIONAL MEETINGS AS SPEAKER
Speaker at 60 national and international meetings.
AWARDS
2010 SIES Award for the project: “THE ROLE OF CHIBBY HAPLOINSUFFICIENCY, ORIGINATED BY GENE DELETION AT CHROMOSOME 22 q13.1, IN THE PATHOGENESIS AND PROGRESSION OF CHRONIC MYELOID LEUKEMIA”
2011 Fondazione Umberto Veronesi Award as Young Investigator for the project: “THE ROLE OF BETA CATENIN ANTAGONIST CHIBBY IN THE PATHOGENESIS AND PROGRESSION OF CHRONIC MYELOID LEUKEMIA”
2012 Fondazione Umberto Veronesi Award as Young Investigator for the project: “THE ROLE OF BETA CATENIN ANTAGONIST CHIBBY IN THE PATHOGENESIS AND PROGRESSION OF CHRONIC MYELOID LEUKEMIA”
2013 Fondazione Umberto Veronesi Award as Young Investigator for the project: “THE ROLE OF FOXM1 HYPERACTIVATION IN CML STEM CELL PROLIFERATION AND SURVIVAL”
2014 Fondazione Umberto Veronesi Award as Young Investigator for the project: “THE ROLE OF FOXM1 HYPERACTIVATION IN CML STEM CELL PROLIFERATION AND SURVIVAL”
2017 ASH Abstract Achievement Award for the abstract: Mancini et al. “SETD2 Loss of Function is a Recurrent Event in Advanced-Phase Chronic Myeloid Leukemia” (presented at the 2017 ASH annual meeting)
