Keywords:
Epilepsy
EEG
Genetics
Epidemiology
Epilepsy Surgery
VNS
Lafora disease
Dravet Syndrome
CAR-T
COVID-19
he main clinical and research interest is focused on epilepsy, with particular attention to rare and complex forms. The main areas include:
• Epidemiology: causes and incidence of hospitalization and mortality in people with epilepsy
• Genetics of epilepsy: next-generation sequencing, genotype-phenotype correlations
• Epilepsy surgery: prolonged V-EEG monitoring, stereo-EEG, prognostic factors
• Neuromodulation: vagus nerve stimulation – long-term efficacy and predictive factors
• Neurophysiology: qualitative and quantitative EEG analysis in various contexts
• Status epilepticus: clinical-instrumental-laboratory characterization, prognostic factors
• Neuropharmacology: clinical trials and real-world analysis, pharmacokinetics studies
In recent years, specific attention has been dedicated to Lafora disease, a rare and fatal form of progressive myoclonic epilepsy of childhood, contributing to the definition of aspects such as pathophysiology, epidemiology, natural history, anatomical-electro-clinical characteristics, as well as the search for new therapies (preparation of clinical trials, translational research).
Additionally, there is an interest in outlining the clinical-laboratory-instrumental characteristics and pathophysiology of acute and chronic neurological manifestations of COVID-19 and neurotoxicity related to CAR-T therapy in patients with lymphoma, conditions characterized by cytokine-mediated neuroinflammation.
