Foto del docente

Giovanni Capranico

Full Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/11 Molecular Biology

Publications

I D'Annessa; C Tesauro; P Fiorani; G Chillemi; S Castelli; O Vassallo; G Capranico; A Desideri, Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin, «JOURNAL OF AMINO ACIDS», 2012, 2012, pp. 1 - 8 [Scientific article]

Capranico G; Baranello L; Bertozzi D; Marinello J, Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity, in: DNA Topoisomerases and Cancer, NEW YORK, Humana Press - Springer Science, 2012, pp. 309 - 324 (CANCER DRUG DISCOVERY AND DEVELOPMENT) [Chapter or essay]

Bertozzi Davide; Iurlaro Raffaella; Sordet Olivier; Marinello Jessica; Zaffaroni Nadia; Capranico Giovanni, Characterization of novel antisense HIF-1α transcripts in human cancers, «CELL CYCLE», 2011, 10, pp. 3189 - 3197 [Scientific article]

Ricci A; Marinello J; Bortolus M; Sanchez A; Grandas A; Pedroso E; Pommier Y; Capranico G; Maniero AL; Zagotto G., Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex., «JOURNAL OF MEDICINAL CHEMISTRY», 2011, 54, pp. 1003 - 1009 [Scientific article]

G. Capranico; J. Marinello; L. Baranello, Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity., «BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER», 2010, 1806(2), pp. 240 - 250 [Scientific article]

L. Baranello; D. Bertozzi; M.V. Fogli; Y. Pommier; G. Capranico, DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus., «NUCLEIC ACIDS RESEARCH», 2010, 38, pp. 159 - 171 [Scientific article]

Lotito L.; Russo A.; Bueno S.; Chillemi G.; Fogli M.V.; Capranico G., A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors., «EUROPEAN JOURNAL OF PHARMACOLOGY», 2009, 603, pp. 29 - 36 [Scientific article]

Tumiatti V; Milelli A ; Minarini A; Micco M; Gasperi-Campani A; Roncuzzi L; Baiocchi D; Marinello J; Capranico G; Zini M; Stefanelli C; Melchiorre C, DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT, «JOURNAL OF MEDICINAL CHEMISTRY», 2009, 52, pp. 7873 - 7877 [Scientific article]

Filosa R.; Peduto A.; Micco S.D.; Caprariis P.D.; Festa M.; Petrella A.; Capranico G.; Bifulco G., Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors., «BIOORGANIC & MEDICINAL CHEMISTRY», 2009, 17, pp. 13 - 24 [Scientific article]

Lotito L.; Russo A.; Chillemi G.; Bueno S.; Cavalieri D.; Capranico G., Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: Activation of telomere-proximal genes by TOP1 deletion, «JOURNAL OF MOLECULAR BIOLOGY», 2008, 377, pp. 311 - 322 [Scientific article]

Dal Ben D.; Palumbo M.; Zagotto G.; Capranico G.; Moro S., DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation., «CURRENT PHARMACEUTICAL DESIGN», 2007, 13, pp. 2766 - 2780 [Scientific article]

Capranico G.; Ferri F.; Fogli M.V.; Russo A.; Lotito L.; Baranello L., The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I., «BIOCHIMIE», 2007, 89, pp. 482 - 489 [Scientific article]

Khobta A; Ferri F; Lotito L; Montecucco A; Rossi R; Capranico G, Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells., «JOURNAL OF MOLECULAR BIOLOGY», 2006, 357, pp. 127 - 138 [Scientific article]

R Tonelli; R Sartini; R Fronza; F Freccero; M Franzoni; D Dongiovanni; M Ballarini; S Ferrari; M D'apolito; G Di Cola; G Capranico; A Khobta; R Campanini; P Paolucci; S Minucci; A Pession, G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent, «LEUKEMIA», 2006, 20(7), pp. 1307 - 1310 [Scientific article]

Tonelli R., Sartini R., Fronza R., Freccero F, Franzoni M., Dongiovanni D., Ballarini M., Ferrari S., D’Apolito M., Di Cola G., Capranico G., Khobta A., Campanini R., Paolucci P., Minucci S., Pession, A., G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent, «BLOOD», 2005, 106, pp. 4410 - 4410 [Abstract]

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