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Giovanni Capranico

Professore ordinario

Dipartimento di Farmacia e Biotecnologie

Settore scientifico disciplinare: BIOS-08/A Biologia molecolare

Pubblicazioni

Simone Pieretti;Jurgen R. Haanstra;Muriel Mazet;Remo Perozzo;Christian Bergamini;Federica Prati;Romana Fato;Giorgio Lenaz;Giovanni Capranico;Reto Brun;Barbara M. Bakker;Paul A. M. Michels;Leonardo Scapozza;Maria Laura Bolognesi;Andrea Cavalli, Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism, «PLOS NEGLECTED TROPICAL DISEASES», 2013, 7, pp. e2012 - e2023 [articolo]

Fornari F.; Milazzo M.; Chieco P.; Negrini M.; Marasco E.; Capranico G.; Mantovani V.; Marinello J.; Sabbioni S.; Callegari E.; Cescon M.; Ravaioli M.; Croce C.M.; Bolondi L.; Gramantieri L., In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2., «JOURNAL OF PATHOLOGY», 2012, 227, pp. 275 - 285 [articolo]

Manzo S. G.; Z.-L. Zhou; Y.-Q. Wang; J. Marinello; J.-X. He; Y.-C. Li; J. Ding; G. Capranico; Z.-H. Miao, Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II, «CANCER RESEARCH», 2012, 72, pp. 5363 - 5373 [articolo]

I D'Annessa; C Tesauro; P Fiorani; G Chillemi; S Castelli; O Vassallo; G Capranico; A Desideri, Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin, «JOURNAL OF AMINO ACIDS», 2012, 2012, pp. 1 - 8 [articolo]

Capranico G; Baranello L; Bertozzi D; Marinello J, Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity, in: DNA Topoisomerases and Cancer, NEW YORK, Humana Press - Springer Science, 2012, pp. 309 - 324 (CANCER DRUG DISCOVERY AND DEVELOPMENT) [capitolo di libro]

Bertozzi Davide; Iurlaro Raffaella; Sordet Olivier; Marinello Jessica; Zaffaroni Nadia; Capranico Giovanni, Characterization of novel antisense HIF-1α transcripts in human cancers, «CELL CYCLE», 2011, 10, pp. 3189 - 3197 [articolo]

Ricci A; Marinello J; Bortolus M; Sanchez A; Grandas A; Pedroso E; Pommier Y; Capranico G; Maniero AL; Zagotto G., Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex., «JOURNAL OF MEDICINAL CHEMISTRY», 2011, 54, pp. 1003 - 1009 [articolo]

G. Capranico; J. Marinello; L. Baranello, Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity., «BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER», 2010, 1806(2), pp. 240 - 250 [articolo]

L. Baranello; D. Bertozzi; M.V. Fogli; Y. Pommier; G. Capranico, DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus., «NUCLEIC ACIDS RESEARCH», 2010, 38, pp. 159 - 171 [articolo]

Lotito L.; Russo A.; Bueno S.; Chillemi G.; Fogli M.V.; Capranico G., A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors., «EUROPEAN JOURNAL OF PHARMACOLOGY», 2009, 603, pp. 29 - 36 [articolo]

Tumiatti V; Milelli A ; Minarini A; Micco M; Gasperi-Campani A; Roncuzzi L; Baiocchi D; Marinello J; Capranico G; Zini M; Stefanelli C; Melchiorre C, DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT, «JOURNAL OF MEDICINAL CHEMISTRY», 2009, 52, pp. 7873 - 7877 [articolo]

Filosa R.; Peduto A.; Micco S.D.; Caprariis P.D.; Festa M.; Petrella A.; Capranico G.; Bifulco G., Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors., «BIOORGANIC & MEDICINAL CHEMISTRY», 2009, 17, pp. 13 - 24 [articolo]

Lotito L.; Russo A.; Chillemi G.; Bueno S.; Cavalieri D.; Capranico G., Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: Activation of telomere-proximal genes by TOP1 deletion, «JOURNAL OF MOLECULAR BIOLOGY», 2008, 377, pp. 311 - 322 [articolo]

Dal Ben D.; Palumbo M.; Zagotto G.; Capranico G.; Moro S., DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation., «CURRENT PHARMACEUTICAL DESIGN», 2007, 13, pp. 2766 - 2780 [articolo]

Capranico G.; Ferri F.; Fogli M.V.; Russo A.; Lotito L.; Baranello L., The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I., «BIOCHIMIE», 2007, 89, pp. 482 - 489 [articolo]

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