Foto del docente

Giovanni Capranico

Professore ordinario

Dipartimento di Farmacia e Biotecnologie

Settore scientifico disciplinare: BIO/11 BIOLOGIA MOLECOLARE

Pubblicazioni

I D'Annessa; C Tesauro; P Fiorani; G Chillemi; S Castelli; O Vassallo; G Capranico; A Desideri, Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin, «JOURNAL OF AMINO ACIDS», 2012, 2012, pp. 1 - 8 [articolo]

Capranico G; Baranello L; Bertozzi D; Marinello J, Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity, in: DNA Topoisomerases and Cancer, NEW YORK, Humana Press - Springer Science, 2012, pp. 309 - 324 (CANCER DRUG DISCOVERY AND DEVELOPMENT) [capitolo di libro]

Bertozzi Davide; Iurlaro Raffaella; Sordet Olivier; Marinello Jessica; Zaffaroni Nadia; Capranico Giovanni, Characterization of novel antisense HIF-1α transcripts in human cancers, «CELL CYCLE», 2011, 10, pp. 3189 - 3197 [articolo]

Ricci A; Marinello J; Bortolus M; Sanchez A; Grandas A; Pedroso E; Pommier Y; Capranico G; Maniero AL; Zagotto G., Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex., «JOURNAL OF MEDICINAL CHEMISTRY», 2011, 54, pp. 1003 - 1009 [articolo]

G. Capranico; J. Marinello; L. Baranello, Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity., «BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER», 2010, 1806(2), pp. 240 - 250 [articolo]

L. Baranello; D. Bertozzi; M.V. Fogli; Y. Pommier; G. Capranico, DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus., «NUCLEIC ACIDS RESEARCH», 2010, 38, pp. 159 - 171 [articolo]

Lotito L.; Russo A.; Bueno S.; Chillemi G.; Fogli M.V.; Capranico G., A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors., «EUROPEAN JOURNAL OF PHARMACOLOGY», 2009, 603, pp. 29 - 36 [articolo]

Tumiatti V; Milelli A ; Minarini A; Micco M; Gasperi-Campani A; Roncuzzi L; Baiocchi D; Marinello J; Capranico G; Zini M; Stefanelli C; Melchiorre C, DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT, «JOURNAL OF MEDICINAL CHEMISTRY», 2009, 52, pp. 7873 - 7877 [articolo]

Filosa R.; Peduto A.; Micco S.D.; Caprariis P.D.; Festa M.; Petrella A.; Capranico G.; Bifulco G., Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors., «BIOORGANIC & MEDICINAL CHEMISTRY», 2009, 17, pp. 13 - 24 [articolo]

Lotito L.; Russo A.; Chillemi G.; Bueno S.; Cavalieri D.; Capranico G., Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: Activation of telomere-proximal genes by TOP1 deletion, «JOURNAL OF MOLECULAR BIOLOGY», 2008, 377, pp. 311 - 322 [articolo]

Dal Ben D.; Palumbo M.; Zagotto G.; Capranico G.; Moro S., DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation., «CURRENT PHARMACEUTICAL DESIGN», 2007, 13, pp. 2766 - 2780 [articolo]

Capranico G.; Ferri F.; Fogli M.V.; Russo A.; Lotito L.; Baranello L., The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I., «BIOCHIMIE», 2007, 89, pp. 482 - 489 [articolo]

Khobta A; Ferri F; Lotito L; Montecucco A; Rossi R; Capranico G, Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells., «JOURNAL OF MOLECULAR BIOLOGY», 2006, 357, pp. 127 - 138 [articolo]

R Tonelli; R Sartini; R Fronza; F Freccero; M Franzoni; D Dongiovanni; M Ballarini; S Ferrari; M D'apolito; G Di Cola; G Capranico; A Khobta; R Campanini; P Paolucci; S Minucci; A Pession, G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent, «LEUKEMIA», 2006, 20(7), pp. 1307 - 1310 [articolo]

Tonelli R., Sartini R., Fronza R., Freccero F, Franzoni M., Dongiovanni D., Ballarini M., Ferrari S., D’Apolito M., Di Cola G., Capranico G., Khobta A., Campanini R., Paolucci P., Minucci S., Pession, A., G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent, «BLOOD», 2005, 106, pp. 4410 - 4410 [abstract]

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