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Pubblicazioni antecedenti il 2004
1986-2001
Capranico G, Soranzo C, Zunino F. Single-strand DNA breaks induced
by chromophore-modified anthracyclines in P388 leukemia cells.
Cancer Res. 1986 Nov;46(11):5499-503.
Capranico G, Dasdia T, Zunino F. Comparison of doxorubicin-induced
DNA damage in doxorubicin-sensitive and -resistant P388 murine
leukemia cells. Int J Cancer. 1986 Feb 15;37(2):227-31.
Capranico G, Babudri N, Casciarri G, Dolzani L, Gambetta RA,
Longoni E, Pani B, Soranzo C, Zunino F. Lack of effect of
glutathione depletion on cytotoxicity, mutagenicity and DNA damage
produced by doxorubicin in cultured cells. Chem Biol Interact. 1986
Feb;57(2):189-201.
Capranico G, Riva A, Tinelli S, Dasdia T, Zunino F. Markedly
reduced levels of anthracycline-induced DNA strand breaks in
resistant P388 leukemia cells and isolated nuclei. Cancer Res. 1987
Jul 15;47(14):3752-6.
Supino R, Mariani M, Capranico G, Colombo A, Parmiani G.
Doxorubicin cellular pharmacokinetics and DNA breakage in a
multi-drug resistant B16 melanoma cell line. Br J Cancer. 1988
Feb;57(2):142-6.
Capranico G, De Isabella P, Penco S, Tinelli S, Zunino F. Role of
DNA breakage in cytotoxicity of doxorubicin, 9-deoxydoxorubicin,
and 4-demethyl-6-deoxydoxorubicin in murine leukemia P388 cells.
Cancer Res. 1989 Apr 15;49(8):2022-7.
Capranico G, De Isabella P, Castelli C, Supino R, Parmiani G,
Zunino F. P-glycoprotein gene amplification and expression in
multidrug-resistant murine P388 and B16 cell lines. Br J Cancer.
1989 May;59(5):682-5.
Capranico G, Tinelli S, Zunino F. Formation, resealing and
persistence of DNA breaks produced by 4-demethoxydaunorubicin in
P388 leukemia cells. Chem Biol Interact. 1989;72(1-2):113-23.
De Isabella P, Capranico G, Binaschi M, Tinelli S, Zunino F.
Evidence of DNA topoisomerase II-dependent mechanisms of multidrug
resistance in P388 leukemia cells. Mol Pharmacol. 1990
Jan;37(1):11-6.
Capranico G, Zunino F, Kohn KW, Pommier Y. Sequence-selective
topoisomerase II inhibition by anthracycline derivatives in SV40
DNA: relationship with DNA binding affinity and cytotoxicity.
Biochemistry. 1990 Jan 16;29(2):562-9.
Binaschi M, Capranico G, De Isabella P, Mariani M, Supino R,
Tinelli S, Zunino F. Comparison of DNA cleavage induced by
etoposide and doxorubicin in two human small-cell lung cancer lines
with different sensitivities to topoisomerase II inhibitors. Int J
Cancer. 1990 Feb 15;45(2):347-52.
Wassermann K, Markovits J, Jaxel C, Capranico G, Kohn KW, Pommier
Y. Effects of morpholinyl doxorubicins, doxorubicin, and
actinomycin D on mammalian DNA topoisomerases I and II. Mol
Pharmacol. 1990 Jul;38(1):38-45.
Capranico G, Jaxel C, Roberge M, Kohn KW, Pommier Y. Nucleosome
positioning as a critical determinant for the DNA cleavage sites of
mammalian DNA topoisomerase II in reconstituted simian virus 40
chromatin. Nucleic Acids Res. 1990 Aug 11;18(15):4553-9.
Capranico G, Kohn KW, Pommier Y. Local sequence requirements for
DNA cleavage by mammalian topoisomerase II in the presence of
doxorubicin. Nucleic Acids Res. 1990 Nov 25;18(22):6611-9.
Pratesi G, Capranico G, Binaschi M, De Isabella P, Pilotti S,
Supino R, Zunino F. Relationships among tumor responsiveness, cell
sensitivity, doxorubicin cellular pharmacokinetics and drug-induced
DNA alterations in two human small-cell lung cancer xenografts. Int
J Cancer. 1990 Oct 15;46(4):669-74.
Zunino F, Capranico G. DNA topoisomerase II as the primary target
of anti-tumor anthracyclines. Anticancer Drug Des. 1990
Nov;5(4):307-17. Review.
De Isabella P, Capranico G, Zunino F. The role of topoisomerase II
in drug resistance. Life Sci. 1991;48(23):2195-205. Review.
Jaxel C, Capranico G, Kerrigan D, Kohn KW, Pommier Y. Effect of
local DNA sequence on topoisomerase I cleavage in the presence or
absence of camptothecin. J Biol Chem. 1991 Oct 25;266(30):20418-23.
Pommier Y, Capranico G, Orr A, Kohn KW. Local base sequence
preferences for DNA cleavage by mammalian topoisomerase II in the
presence of amsacrine or teniposide. Nucleic Acids Res. 1991 Nov
11;19(21):5973-80. [Erratum in: Nucleic Acids Res 1991 Dec
25;19(24):7003.]
Pommier Y, Capranico G, Orr A, Kohn KW. Distribution of
topoisomerase II cleavage sites in simian virus 40 DNA and the
effects of drugs. J Mol Biol. 1991 Dec 20;222(4):909-24.
Capranico G, Zunino F. DNA topoisomerase-trapping antitumour drugs.
Eur J Cancer. 1992;28A(12):2055-60. Review.
Giaccone G, Gazdar AF, Beck H, Zunino F, Capranico G. Multidrug
sensitivity phenotype of human lung cancer cells associated with
topoisomerase II expression. Cancer Res. 1992 Apr 1;52(7):1666-74.
Capranico G, Tinelli S, Austin CA, Fisher ML, Zunino F. Different
patterns of gene expression of topoisomerase II isoforms in
differentiated tissues during murine development. Biochim Biophys
Acta. 1992 Aug 17;1132(1):43-8.
Zunino F, Capranico G, Pratesi G, Spinelli S. Current approaches to
new drug development in cancer chemotherapy. Farmaco. 1992
Sep;47(9):1115-32. Review.
Binaschi M, Giaccone G, Gazdar AF, De Isabella P, Ricotti GC,
Capranico G, Zunino F. Characterization of a topoisomerase II gene
rearrangement in a human small-cell lung cancer cell line. J Natl
Cancer Inst. 1992 Nov 18;84(22):1710-6. [Erratum in: J Natl Cancer
Inst 1993 Jan 20;85(2):163.]
Capranico G, Tinelli S, Zunino F, Kohn KW, Pommier Y. Effects of
base mutations on topoisomerase II DNA cleavage stimulated by mAMSA
in short DNA oligomers. Biochemistry. 1993 Jan 12;32(1):145-52.
Capranico G, De Isabella P, Tinelli S, Bigioni M, Zunino F. Similar
sequence specificity of mitoxantrone and VM-26 stimulation of in
vitro DNA cleavage by mammalian DNA topoisomerase II. Biochemistry.
1993 Mar 30;32(12):3038-46.
De Isabella P, Capranico G, Palumbo M, Sissi C, Krapcho AP, Zunino
F. Sequence selectivity of topoisomerase II DNA cleavage stimulated
by mitoxantrone derivatives: relationships to drug DNA binding and
cellular effects. Mol Pharmacol. 1993 May;43(5):715-21.
Supino R, Binaschi M, Capranico G, Gambetta RA, Prosperi E, Sala E,
Zunino F. A study of cross-resistance pattern and expression of
molecular markers of multidrug resistance in a human small-cell
lung-cancer cell line selected with doxorubicin. Int J Cancer. 1993
May 8;54(2):309-14.
Capranico G, Palumbo M, Tinelli S, Mabilia M, Pozzan A, Zunino F.
Conformational drug determinants of the sequence specificity of
drug-stimulated topoisomerase II DNA cleavage. J Mol Biol. 1994 Jan
28;235(4):1218-30.
Capranico G, Supino R, Binaschi M, Capolongo L, Grandi M, Suarato
A, Zunino F. Influence of structural modifications at the 3' and 4'
positions of doxorubicin on the drug ability to trap topoisomerase
II and to overcome multidrug resistance. Mol Pharmacol. 1994
May;45(5):908-15.
Bigioni M, Zunino F, Capranico G. Base mutation analysis of
topoisomerase II-idarubicin-DNA ternary complex formation. Evidence
for enzyme subunit cooperativity in DNA cleavage. Nucleic Acids
Res. 1994 Jun 25;22(12):2274-81.
Palumbo M, Mabilia M, Pozzan A, Capranico G, Tinelli S, Zunino F.
Conformational properties of topoisomerase II inhibitors and
sequence specificity of DNA cleavage. J Mol Recognit. 1994
Sep;7(3):227-31.
Capranico G, Palumbo M, Tinelli S, Zunino F. Unique sequence
specificity of topoisomerase II DNA cleavage stimulation and DNA
binding mode of streptonigrin. J Biol Chem. 1994 Oct
7;269(40):25004-9.
Perego P, Capranico G, Supino R, Zunino F. Topoisomerase I gene
expression and cell sensitivity to camptothecin in human cell lines
of different tumor types. Anticancer Drugs. 1994 Dec;5(6):645-9.
Capranico G, Butelli E, Zunino F. Change of the sequence
specificity of daunorubicin-stimulated topoisomerase II DNA
cleavage by epimerization of the amino group of the sugar moiety.
Cancer Res. 1995 Jan 15;55(2):312-7.
De Isabella P, Zunino F, Capranico G. Base sequence determinants of
amonafide stimulation of topoisomerase II DNA cleavage. Nucleic
Acids Res. 1995 Jan 25;23(2):223-9.
Binaschi M, Zunino F, Capranico G. Mechanism of action of DNA
topoisomerase inhibitors. Stem Cells. 1995 Jul;13(4):369-79.
Review.
Capranico G, Zunino F. Antitumor inhibitors of DNA topoisomerases.
Curr Pharm Des. 1995; 1(1):1-14.
Zunino F, Animati F, Capranico G. DNA minor-groove binding drugs.
Curr Pharm Des 1995; 1(1):83-94.
De Isabella P, Palumbo M, Sissi C, Capranico G, Carenini N, Menta
E, Oliva A, Spinelli S, Krapcho AP, Giuliani FC, Zunino F.
Topoisomerase II DNA cleavage stimulation, DNA binding activity,
cytotoxicity, and physico-chemical properties of 2-aza- and
2-aza-oxide-anthracenedione derivatives. Mol Pharmacol. 1995
Jul;48(1):30-8.
Binaschi M, Supino R, Gambetta RA, Giaccone G, Prosperi E,
Capranico G, Cataldo I, Zunino F. MRP gene overexpression in a
human doxorubicin-resistant SCLC cell line: alterations in cellular
pharmacokinetics and in pattern of cross-resistance. Int J Cancer.
1995 Jul 4;62(1):84-9.
Giaccone G, van Ark-Otte J, Scagliotti G, Capranico G, van der Valk
P, Rubio G, Dalesio O, Lopez R, Zunino F, Walboomers J, Walboomers
J, Pinedo HM. Differential expression of DNA topoisomerases in
non-small cell lung cancer and normal lung. Biochim Biophys Acta.
1995 Dec 27;1264(3):337-46.
Bigioni M, Zunino F, Tinelli S, Austin CA, Willmore E, Capranico G.
Position-specific effects of base mismatch on mammalian
topoisomerase II DNA cleaving activity. Biochemistry. 1996 Jan
9;35(1):153-9.
Borgnetto ME, Zunino F, Tinelli S, Kas E, Capranico G.
Drug-specific sites of topoisomerase II DNA cleavage in Drosophila
chromatin: heterogeneous localization and reversibility. Cancer
Res. 1996 Apr 15;56(8):1855-62.
Marchesini R, Colombo A, Caserini C, Perego P, Supino R, Capranico
G, Tronconi M, Zunino F. Interaction of ionizing radiation with
topotecan in two human tumor cell lines. Int J Cancer. 1996 May
3;66(3):342-6.
Gatto B, Zagotto G, Sissi C, Cera C, Uriarte E, Palu G, Capranico
G, Palumbo M. Peptidyl anthraquinones as potential antineoplastic
drugs: synthesis, DNA binding, redox cycling, and biological
activity. J Med Chem. 1996 Aug 2;39(16):3114-22.
Cornarotti M, Capranico G, Bohm S, Oriana S, Spatti GB, Mariani L,
Ballabio G, Zunino F. Gene expression of DNA topoisomerases I, II
alpha and II beta and response to cisplatin-based chemotherapy in
advanced ovarian carcinoma. Int J Cancer. 1996 Aug 7;67(4):479-84.
Animati F, Arcamone F, Bigioni M, Capranico G, Caserini C, De
Cesare M, Lombardi P, Pratesi G, Salvatore C, Supino R, Zunino
F. Biochemical and pharmacological activity of novel
8-fluoroanthracyclines: influence of stereochemistry and
conformation. Mol Pharmacol. 1996 Sep;50(3):603-9.
Sissi C, Capranico G, Menta E, Palumbo M. Aza-bioisosteres of 9,
10-anthracenedione: a modulation of DNA sequence specificity. Mol
Pharmacol. 1996 Oct;50(4):838-45.
Cornarotti M, Tinelli S, Willmore E, Zunino F, Fisher LM, Austin
CA, Capranico G. Drug sensitivity and sequence specificity of human
recombinant DNA topoisomerases IIalpha (p170) and IIbeta (p180).
Mol Pharmacol. 1996 Dec;50(6):1463-71.
Marsh KL, Willmore E, Tinelli S, Cornarotti M, Meczes EL, Capranico
G, Fisher LM, Austin CA. Amsacrine-promoted DNA cleavage site
determinants for the two human DNA topoisomerase II isoforms alpha
and beta. Biochem Pharmacol. 1996 Dec 13;52(11):1675-85.
De Isabella P, Palumbo M, Sissi C, Carenini N, Capranico G, Menta
E, Oliva A, Spinelli S, Krapcho AP, Giuliani FC, Zunino F.
Physicochemical properties, cytotoxic activity and topoisomerase II
inhibition of 2,3-diaza-anthracenediones. Biochem Pharmacol. 1997
Jan 24;53(2):161-9.
Binaschi M, Zagotto G, Palumbo M, Zunino F, Farinosi R, Capranico
G. Irreversible and reversible topoisomerase II DNA cleavage
stimulated by clerocidin: sequence specificity and structural drug
determinants. Cancer Res. 1997 May 1;57(9):1710-6.
Binaschi M, Capranico G, Dal Bo L, Zunino F. Relationship between
lethal effects and topoisomerase II-mediated double-stranded DNA
breaks produced by anthracyclines with different sequence
specificity. Mol Pharmacol. 1997 Jun;51(6):1053-9.
Arcamone F, Animati F, Berettoni M, Bigioni M, Capranico G, Casazza
AM, Caserini C, Cipollone A, De Cesare M, Franciotti M, Lombardi P,
Madami A, Manzini S, Monteagudo E, Polizzi D, Pratesi G, Righetti
SC, Salvatore C, Supino R, Zunino F. Doxorubicin disaccharide
analogue: apoptosis-related improvement of efficacy in vivo. J Natl
Cancer Inst. 1997 Aug 20;89(16):1217-23.
Capranico G, Binaschi M, Borgnetto ME, Zunino F, Palumbo M. A
protein-mediated mechanism for the DNA sequence-specific action of
topoisomerase II poisons. Trends Pharmacol Sci. 1997
Sep;18(9):323-9. Review.
Arcamone F, Animati F, Capranico G, Lombardi P, Pratesi G, Manzini
S, Supino R, Zunino F. New developments in antitumor
anthracyclines. Pharmacol Ther. 1997 Oct-Dec;76(1-3):117-24.
Review.
Binaschi M, Farinosi R, Austin CA, Fisher LM, Zunino F, Capranico
G. Human DNA topoisomerase IIalpha-dependent DNA cleavage and yeast
cell killing by anthracycline analogues. Cancer Res. 1998 May
1;58(9):1886-92.
Capranico G, Guano F, Moro S, Zagotto G, Sissi C, Gatto B, Zunino
F, Menta E, Palumbo M. Mapping drug interactions at the covalent
topoisomerase II-DNA complex by bisantrene/amsacrine congeners. J
Biol Chem. 1998 May 22;273(21):12732-9.
Capranico G, Binaschi M. DNA sequence selectivity of topoisomerases
and topoisomerase poisons. Biochim Biophys Acta. 1998 Oct
1;1400(1-3):185-94. Review.
Sissi C, Bolgan L, Moro S, Zagotto G, Bailly C, Menta E, Capranico
G, Palumbo M. DNA-binding preferences of bisantrene analogues:
relevance to the sequence specificity of drug-mediated
topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.
Zagotto G, Oliva A, Guano F, Menta E, Capranico G, Palumbo M.
Synthesis, DNA-damaging and cytotoxic properties of novel
topoisomerase II-directed bisantrene analogues. Bioorg Med Chem
Lett. 1998 Jan 20;8(2):121-6.
Borgnetto ME, Tinelli S, Carminati L, Capranico G. Genomic sites of
topoisomerase II activity determined by comparing DNA breakage
enhanced by three distinct poisons. J Mol Biol. 1999 Jan
15;285(2):545-54.
Gatto B, Capranico G, Palumbo M. Drugs acting on DNA
topoisomerases: recent advances and future perspectives. Curr Pharm
Des. 1999 Mar;5(3):195-215. Review.
Guano F, Pourquier P, Tinelli S, Binaschi M, Bigioni M, Animati F,
Manzini S, Zunino F, Kohlhagen G, Pommier Y, Capranico G.
Topoisomerase poisoning activity of novel disaccharide
anthracyclines. Mol Pharmacol. 1999 Jul;56(1):77-84.
Beretta GL, Binaschi M, Zagni E, Capuani L, Capranico G. Tethering
a type IB topoisomerase to a DNA site by enzyme fusion to a
heterologous site-selective DNA-binding protein domain. Cancer Res.
1999 Aug 1;59(15):3689-97.
Binaschi M, Farinosi R, Borgnetto ME, Capranico G. Detection of
cellular DNA cleavage using non-proofreading thermostable DNA
polymerases. Biotechniques. 2000 Jun;28(6):1064-6. No abstract
available.
Binaschi M, Farinosi R, Borgnetto ME, Capranico G. In vivo site
specificity and human isoenzyme selectivity of two topoisomerase
II-poisoning anthracyclines. Cancer Res. 2000 Jul 15;60(14):3770-6.
Binaschi M, Borgnetto ME, Capranico G. Loss of drug-stimulated
topoisomerase II DNA breaks in living cells is different at two
unrelated loci. Nucleic Acids Res. 2000 Sep 1;28(17):3289-93.
Arcamone F, Animati F, Bigioni M, Capranico G, Caserini C,
Cipollone A, De Cesare M, Ettorre A, Guano F, Manzini S, Monteagudo
E, Pratesi G, Salvatore C, Supino R, Zunino F. Configurational
requirements of the sugar moiety for the pharmacological activity
of anthracycline disaccharides. Biochem Pharmacol. 1999 May
15;57(10):1133-9.
Bigioni M, Salvatore C, Bullo A, Bellarosa D, Iafrate E, Animati F,
Capranico G, Goso C, Maggi CA, Pratesi G, Zunino F, Manzini S. A
comparative study of cellular and molecular pharmacology of
doxorubicin and MEN 10755, a disaccharide analogue. Biochem
Pharmacol. 2001 Jul 1;62(1):63-70.
Scaldaferro S, Tinelli S, Borgnetto ME, Azzini A, Capranico G.
Directed evolution to increase camptothecin sensitivity of human
DNA topoisomerase I. Chem Biol. 2001 Sep;8(9):871-81.
Supino R, Polizzi D, Pavesi R, Pratesi G, Guano F, Capranico G,
Palumbo M, Sissi C, Richter S, Beggiolin G, Menta E, Pezzoni G,
Spinelli S, Torriani D, Carenini N, Dal Bo L, Facchinetti F,
Tortoreto M, Zunino F. A novel 9-aza-anthrapyrazole effective
against human prostatic carcinoma xenografts. Oncology.
2001;61(3):234-42.
Gatto B, Richter S, Moro S, Capranico G, Palumbo M. The
topoisomerase II poison clerocidin alkylates non-paired guanines of
DNA: implications for irreversible stimulation of DNA cleavage.
Nucleic Acids Res. 2001 Oct 15;29(20):4224-30.
Binaschi M, Bigioni M, Cipollone A, Rossi C, Goso C, Maggi CA,
Capranico G, Animati F. Anthracyclines: selected new developments.
Curr Med Chem Anticancer Agents. 2001 Aug;1(2):113-30.
Review.
