Foto del docente

Giampaolo Zuccheri

Assistant professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/06 Organic Chemistry


1) DNA Nanotechnology
2) Atomic Force Microscopy and related techniques
3) Biosensors

1) DNA Nanotechnology: using DNA and nucleic acids as building material for nanostructures by design. Static or dynamic bottom-up self-assemblying nanostructures can be obtained and are characterized with biochemical, spectroscopic, microscopic and structural biology techniques.
2) Atomic Force Microscopy: the development and use of atomic force microscopy and related techniques for studying biological macromolecules and their interaction with materials. It includes the development of the instrumentation, of the protocols, and fo data processing. Some of the main themes of research are the characerization of nucleic acids (natural or synthetic structures) and of proteins, also using the newly developed 'single molecule force spectroscopy' which allow us to study the mechanochemical behavior of molecules. 
3) Biosensors. Development of strategies towarrds the read-out and amplification of signals derived from molecular recognition between nucleic acids or protein markers for diagnostic or analytical applications. We are developing the sensitive interfaces, the electronic methods for read-out, and strategies for signal amplification through nanotechnology and biochemistry, within a collaboration with the Department of Electronics at the University of Bologna.