Leukemic Microenvironment and Tumor–Immune Interactions
This research focuses on understanding the complex interactions between leukemic cells and the bone marrow microenvironment. Particular attention is devoted to the role of stromal and immune components in leukemia progression, immune evasion mechanisms, and the development of therapy resistance. An additional area of interest involves investigating the spatial organization of the bone marrow microenvironment through advanced spatial proteomics and transcriptomics approaches applied to bone marrow biopsies.
Cellular Metabolism and Immunometabolism in Liquid Biopsy
This research line is dedicated to studying the metabolic pathways that regulate leukemic cell survival and the functional activity of circulating immune cells. In particular, the aim is to understand how metabolic reprogramming within the tumor microenvironment influences immune responses and disease progression by using liquid biopsy approaches, including analyses performed at very early stages of the disease.
Extracellular Vesicles, Liquid Biopsy and Biomarker Discovery
This research investigates extracellular vesicles as key mediators of communication between leukemic cells and the surrounding microenvironment. The work includes the development of liquid biopsy approaches based on the analysis of extracellular vesicles isolated from peripheral blood, with the aim of identifying novel biomarkers for diagnosis, prognosis, and monitoring of therapeutic responses in leukemia patients, including at early stages of the disease.
