Foto del docente

Donatella Canistro

Assistant professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/14 Pharmacology


Keywords: Free radicals Antioxidants Monooxygenases Toxicity animal models Vegetable extracts

-Xenobiotic (drugs and environmental contaminants) bioactivation by oxidative and post-oxidative enzymatic activity determination. - In vivo biomarkers of effect for chemical Phase-I and Phase-II enzymatic modulation, employing specific probes and applying spectrophotometric, spectrofluorimetric, chromatographic approaches. - Animal models for toxicity studies. -Development of analytical HPLC methods (LC/MS-ESI probe, UV, PDA, electrochemical detectors) to detect antioxidants in complex matrices. -In vivo (animal and human) oxidative stress status (OSS) measurement, to better understand the mechanisms at the base of different pathologies. "Spin-scavenger" probes to directly detect OSS by means of EPR spectroscopy.