-Xenobiotic (drugs and environmental contaminants)
bioactivation by oxidative and post-oxidative enzymatic
activity determination. - In vivo biomarkers of effect
for chemical Phase-I and Phase-II enzymatic modulation,
employing specific probes and applying spectrophotometric,
spectrofluorimetric, chromatographic approaches. - Animal models
for toxicity studies. -Development of analytical HPLC methods
(LC/MS-ESI probe, UV, PDA, electrochemical detectors) to
detect antioxidants in complex matrices. -In vivo
(animal and human) oxidative stress status (OSS)
measurement, to better understand the mechanisms at
the base of different pathologies. "Spin-scavenger" probes to
directly detect OSS by means of EPR
spectroscopy.
