Argomenti di tesi proposti dal docente.
Tesi sperimentali
Impiego di biomarcatori di effetto per lo studio della modulazione dell'attività degli enzimi del drug metabolism da xenobiotici in vivo (in differenti modelli sperimentali), mediante utilizzo di tecniche spettrofotometriche e fluorimetriche.
Impiego di modelli animali per studi di tossicità.
Misurazione dello stress ossidativo (OSS) in vivo (animale e uomo), fondamentale per l'approfondimento dei meccanismi alla base di molteplici patologie.
Tesi compilative
Interazioni farmaco-farmaco, farmaco-alimenti.
National and International contact details for traineeship and thesis other than UNIBO
· Dott.ssa Monica Montesi, National Research Council of Italy-Institute of Science, Technology and Sustainability for Ceramics (CNR – ISSMC), Faenza
Research Topic: Development of multidimensional in vitro model mimicking the osteosarcoma CSCs-tumour microenvironment complexity
· Dott. Andrea Vornoli, Istituto di Biologia e Biotecnologia Agraria, CNR, Pisa
Research Topic: In vivo,in vitro e in silico approaches combining cell biology, biochemistry, biophysics and structural biology (cryo-EM, X-ray crystallography, computational modeling) to clarify the link between subcellular organization, molecular structure and physiological function, with implications in the biotechnology, agri-food and biomedical fields
· Prof. Lucy C Fairclough, School of Life Sciences, University of Nottingham, UK
Research Topic: Professor Fairclough's research examines the immune mechanisms driving allergic sensitisation and the effects of cigarette smoke/E Cigarette vape on immune cells and inflammation. She utilises cutting-edge imaging and spectral flow cytometry, as well as multiplex technologies, to address these research questions.
· Prof. Mercè Pallas Llibera, Departament de Farmacologia, Toxicologia i Química Terapèutica, Universitat de Barcelona
Research Topic: Neurodegeneration and neuroprotection; Neurodegenerative processes in aging; Pharmacological evaluation of new compounds for the treatment of Alzheimer's disease
· Prof. Inmaculada Concepciòn Posadas Mayo, Departamento de Ciencias Médicas,
Universidad de Castilla-La Mancha
Research Topic: Study of the molecular mechanisms—ion channels, mitochondria, caspases, and ionotropic receptors—involved in the development of neurodegenerative diseases. Use of nanoparticles as therapeutic agents, either on their own or as carriers of genetic material. Target diseases include cancer, neurodegenerative diseases, and autoimmune diseases (multiple sclerosis and Satoyoshi syndrome).
· Prof. Ana Margarida Molhinho Advinha, Departamento de Ciências Médicas e da Saúde, Universidade de Évora
Research Topic: Clinical TRIALS - Revolutionizing Experimental Approaches with Data-driven Yield
