Davide Roncarati graduated cum laude in Biotechnology in
2003 at the University of Bologna, with a research work about the
functional characterization of a transcriptional repressor involved
in the regulation of heat-shock genes in the human pathogen
Helicobacter pylori. From 2004 to 2006 he was a Ph.D.
student in the Ph.D. program ‘Functional Biology of Cellular and
Molecular Systems', in the laboratory of Molecular Biology run by
Professor Vincenzo Scarlato at the University of Bologna: his Ph.D.
project was about the dissection of a complex regulatory network
governing the expression of the major heat-shock genes in H.
pylori. During his Ph.D., Davide Roncarati spent twelve months
in the Molecular Immunology Unit of the company ‘Novartis Vaccines
and Diagnostics' (former ‘Chiron Vaccines'), in Siena (Italy).
During this period in the laboratory of Molecular Biology run by
Dr. Isabel Delany, he studied the regulation of different genes
involved in the protection of the human pathogen Neisseria
meningitidis against reactive oxygen species (ROS). In 2007 he
won a 2-year post-doctoral fellowship (Assegno di Ricerca) to work
on the analysis of different molecular mechanisms that control gene
expression upon environmental signals essential for H.
pylori pathogenesis, in the laboratory of Prof. Scarlato at the
Department of Biology, University of Bologna. Moreover, he was also
involved in the dissection of the regulatory circuit of two
pleiotropic metal-responsive transcriptional regulators (Fur and
NikR), which control the concerted expression of genes coding for
proteins involved in metal homeostasis and virulence.
In November 2008 he was appointed Research Associate in
Molecular Biology at the Department of Biology, Faculty of Science,
University of Bologna. He is lecturer of the course ‘Laboratory of
Molecular Biology II' in the BS degree course in Biotechnologies of
the University of Bologna.
From January 2009 to July 2010 he worked in the laboratory of
Dr. Petros Ligoxygakis at the Department of Biochemistry,
University of Oxford (UK), where he deepened some topics about
host-pathogen interaction, using Drosophila melanogaster as
a model host. During this period, he also worked in the group
of Dr. Maria Harkiolaki, Division of Structural Biology,
Wellcome Trust Centre for Human Genetics (University of Oxford,
UK), where he was involved in the structural characterization
of soluble receptors of Drosophila, responsible for the
recognition of bacterial pathogens.