Foto del docente

Davide Roncarati

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/11 Molecular Biology

Curriculum vitae

Davide Roncarati graduated cum laude in Biotechnology in 2003 at the University of Bologna, with a research work about the functional characterization of a transcriptional repressor involved in the regulation of heat-shock genes in the human pathogen Helicobacter pylori. From 2004 to 2006 he was a Ph.D. student in the Ph.D. program ‘Functional Biology of Cellular and Molecular Systems', in the laboratory of Molecular Biology run by Professor Vincenzo Scarlato at the University of Bologna: his Ph.D. project was about the dissection of a complex regulatory network governing the expression of the major heat-shock genes in H. pylori. During his Ph.D., Davide Roncarati spent twelve months in the Molecular Immunology Unit of the company ‘Novartis Vaccines and Diagnostics' (former ‘Chiron Vaccines'), in Siena (Italy). During this period in the laboratory of Molecular Biology run by Dr. Isabel Delany, he studied the regulation of different genes involved in the protection of the human pathogen Neisseria meningitidis against reactive oxygen species (ROS). In 2007 he won a 2-year post-doctoral fellowship (Assegno di Ricerca) to work on the analysis of different molecular mechanisms that control gene expression upon environmental signals essential for H. pylori pathogenesis, in the laboratory of Prof. Scarlato at the Department of Biology, University of Bologna. Moreover, he was also involved in the dissection of the regulatory circuit of two pleiotropic metal-responsive transcriptional regulators (Fur and NikR), which control the concerted expression of genes coding for proteins involved in metal homeostasis and virulence.

In November 2008 he was appointed Research Associate in Molecular Biology at the Department of Biology, Faculty of Science, University of Bologna. He is lecturer of the course ‘Laboratory of Molecular Biology II' in the BS degree course in Biotechnologies of the University of Bologna.

From January 2009 to July 2010 he worked in the laboratory of Dr. Petros Ligoxygakis at the Department of Biochemistry, University of Oxford (UK), where he deepened some topics about host-pathogen interaction, using Drosophila melanogaster as a model host. During this period, he also worked in the group of Dr. Maria Harkiolaki, Division of Structural Biology, Wellcome Trust Centre for Human Genetics (University of Oxford, UK), where he was involved in the structural characterization of soluble receptors of Drosophila, responsible for the recognition of bacterial pathogens. 

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