Foto del docente

Carlo Ventura

Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Academic discipline: BIO/11 Molecular Biology

Research

Keywords: Physical Energies Myocardial Infarction Cell Reprogramming Cell Therapy in Humans Revascularization Stem Cells Tissue Regeneration

- Isolation and characterization of human mesenchymal stem cells (hMSCs) from bone marrow and alternative sources, including the dental pulp, the fetal membranes from term placenta, and adipose tissue.

- Molecular dissection of cardiovascular commitment.

- Development of new molecules harboring both differentiating logics and paracrine patterning for cardiovascular repair with hMSCs.

- “Secretome” analyses of the overall secretory patterns of angiogenetic, mitogenic, antiapoptotic and antifibrotic factors.

- Assessment of the rescuing potential of wild-type and ex vivo-committed hMSCs in in vivo rat and swine models of myocardial infarction.

- Development of novel scaffolds encompassing both the stem cell and differentiating molecules for paracrine release of trophic mediators.

- Deployment of ex vivo expansion of multipotent cells onto defined nanofabricated scaffolds, and in vivo implantation of cell-enriched scaffolds within damaged hearts.

- MicroPET analysis in infarcted rats of stem cell-mediated angiogenesis, stem cell homing and engraftment.

- Processing of human fat with innovative methods and devices to yield a micro-fractured tissue product harboring an intact stromal-vascular niche embedding cellular elements with pericyte identity. This product is ready-to-use as autologous tissue transplant in humans.

- Use of physical energies, including electromagntic fields, asymmetrically conveyed radio electric fields, and acoustic vibrations do drive the reprogramming to an embryonic-like state of both adult stem and non-stem human somatic cells.

- Deployment of electromagnetic fields and sound vibrations to counteract and revert human stem cell senescence in vitro.

- Use of developmental stage zebrafish embryo extracts to drive reprogramming and differentiation patterning in human adult stem cells, and prevent or revert stem cell senescence in vitro.

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