Foto del docente

Carlo Ventura

Full Professor

Department of Medical and Surgical Sciences

Academic discipline: BIO/11 Molecular Biology


Keywords: Physical Energies Myocardial Infarction Cell Reprogramming Cell Therapy in Humans Revascularization Stem Cells Tissue Regeneration Mechanobiology Acoustic and subsonic waves Photobiomodulation Hyperspectral Imaging Atomic Force Microscopy (AFM)

- Isolation and characterization of human mesenchymal stem cells (hMSCs) from bone marrow and alternative sources, including the dental pulp, the fetal membranes from term placenta, and adipose tissue.

- Molecular dissection of cardiovascular commitment.

- Development of new molecules harboring both differentiating logics and paracrine patterning for cardiovascular repair with hMSCs.

- “Secretome” analyses of the overall secretory patterns of angiogenetic, mitogenic, antiapoptotic and antifibrotic factors.

- Atomic Force Microscopy (AFM) analysis of nanomechanical patterning during stem cell commitment and differentiation.

- Hyperspectral Imaging analysis of (stem) cell fate.

- Photobiomodulation.

- Development of (nano)mechanical actuators, electromagnetic and photobiomodulation devices for efficient reprogramming of human somatic and stem cells.

- Use of physical energies, including electromagntic fields, acoustic and subsonic vibrations, and light  to enhance the capability of human stem cells to cope with hostile in vitro environments (hypoxia, oxidative stress), and afford efficient reversal of (stem) cell senescence patterning.

- Processing of human fat with innovative methods and devices to yield a micro-fractured tissue product harboring an intact stromal-vascular niche embedding cellular elements with pericyte identity. This product is ready-to-use as autologous tissue transplant in humans.

- Development of innovative biobanking strategies of human adipose tissue. 

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