- Isolation and characterization of human mesenchymal stem cells
(hMSCs) from bone marrow and alternative sources, including the
dental pulp, the fetal membranes from term placenta, and adipose
- Molecular dissection of cardiovascular commitment.
- Development of new molecules harboring both differentiating
logics and paracrine patterning for cardiovascular repair with
- “Secretome” analyses of the overall secretory patterns of
angiogenetic, mitogenic, antiapoptotic and antifibrotic
- Assessment of the rescuing potential of wild-type and ex
vivo-committed hMSCs in in vivo rat and swine
models of myocardial infarction.
- Development of novel scaffolds encompassing both the stem cell
and differentiating molecules for paracrine release of trophic
- Deployment of ex vivo expansion of multipotent
cells onto defined nanofabricated scaffolds, and in
vivo implantation of cell-enriched scaffolds within
- MicroPET analysis in infarcted rats of stem cell-mediated
angiogenesis, stem cell homing and engraftment.
- Processing of human fat with innovative methods and devices to
yield a micro-fractured tissue product harboring an intact
stromal-vascular niche embedding cellular elements with
pericyte identity. This product is ready-to-use as autologous
tissue transplant in humans.
- Use of physical energies, including electromagntic fields,
asymmetrically conveyed radio electric fields, and acoustic
vibrations do drive the reprogramming to an embryonic-like state of
both adult stem and non-stem human somatic cells.
- Deployment of electromagnetic fields and sound vibrations to
counteract and revert human stem cell senescence in
- Use of developmental stage zebrafish embryo extracts to
drive reprogramming and differentiation patterning in human adult
stem cells, and prevent or revert stem cell senescence in