My research focuses on the development of innovative drug delivery systems and advanced pharmaceutical dosage forms, with particular emphasis on improving the bioavailability, stability, and therapeutic efficacy of active pharmaceutical ingredients (APIs), biomolecules, natural products, and nutraceuticals. The main research areas include:
1. Innovative Drug Delivery Systems and Solid Dosage Forms
Development and characterization of innovative oral drug delivery systems for pharmaceuticals and biomolecules, with particular emphasis on lipid microparticles, polymer–lipid systems, and other formulations produced using solvent-free technologies. Research activities include the investigation of drug release mechanisms, biopharmaceutical performance, and the relationships between formulation structure, solid-state properties, and product performance.
2. Formulation Strategies to Improve Bioavailability
Design and development of formulations aimed at enhancing the solubility and oral bioavailability of poorly water-soluble active pharmaceutical ingredients through solid dispersions and lipid- and polymer-based delivery systems. This research also focuses on drug–excipient interactions, solid-state characterization, and their impact on biopharmaceutical properties.
3. Pediatric Drug Formulation
Design and development of age-appropriate solid dosage forms for pediatric patients, including granules, mini-tablets, microparticles, and orodispersible films. Particular attention is devoted to dose flexibility, patient acceptability, and ease of administration.
4. Natural Deep Eutectic Solvents (NaDES) and Novel Formulation Approaches
Investigation of Natural Deep Eutectic Solvents (NaDES) as innovative pharmaceutical excipients to improve the solubility, stability, and oral delivery of challenging active pharmaceutical ingredients. Current research also explores the interactions between eutectic solvents, polymers, and biomolecules to develop next-generation pharmaceutical formulations.
5. Functional Polymeric Films and Biomaterials
Development of biodegradable polymeric films produced through sustainable ("green") manufacturing processes for skin and mucosal applications. Research includes the incorporation of naturally derived bioactive compounds and the evaluation of mechanical, mucoadhesive, antibacterial, regenerative, and controlled-release properties, with potential applications in wound healing and mucosal drug delivery.
Overall, my research integrates expertise in preformulation studies, pharmaceutical technology, solid-state characterization, advanced dosage form design, and technology transfer, with a strong focus on collaboration with the pharmaceutical industry and the development of formulations suitable for industrial translation.
