Foto del docente

Antonio Gonzalez Vara Rodriguez

Assistant professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/11 Chemistry and Biotechnology of Fermentation

Curriculum vitae


Personal  data



Family name: González Vara y Rodríguez .

First name: Antonio.

Place of birth and date: Avila (Spain), 25th March 1964.






- Oct 1998-to date: Aggregate Professor.  Place: Faculty of Industrial Chemistry. University of Bologna (Italy).

- Oct 2002-to date: Forward Contract Professor. Place: Faculty of Sciences. University of Urbino (Italy).

- May 1999-May 2001: Research Assistant Professor. Place: Center for Process Biotechnology. Technical University of Denmark.

-   Sep 1996-Jul 97: Forward Contract Professor. Place: Faculty of Sciences. University of Bologna (Italy).

- Feb 1994: Elected member (corespondent) of the Royal Academy of Doctors of Spain. Place: Madrid (Spain).

- Sep 1992-Sep 95: Ph.D. in Applied Biocatalysis and Industrial Fermentations. PhD mark: Summa cum Laude . Place: Consortium of Universities of Bologna, Ferrara and Padova (Italy). Title of PhD Thesis : “Produzione di acido L(+) and D(-) lattico in chemostato. Studio cinetico e modellazione matematica” (Production of L(+) and D(-) lactic acid in chemostat. Study of kinetics and mathematic modellation). Scientific supervisor: Prof. Diego Matteuzzi.

- Jan1988-Jul 91: Ph.D. in Pharmacy. PhD mark: Summa cum Laude . Place: Royal College of Spain. Bologna (Italy). Title of PhD Thesis: “Costruzioni di vettori shuttle derivati da un plasmide nativo di Bacillus coagulans. Clonaggio in Bacillus subtilis e studio di stabilità in fermentatore” (Costruction of shuttle vectors derived from a native plasmid of Bacillus coagulans. Cloning in Bacillus subtillis and study of stability in fermentor). Scientific supervisor: Prof. Diego Matteuzzi.

- Jan 1990-Jul 91: Laurea  in Farmacia (M.Sc. in Pharmacy). Final mark: 110/110 e Lode. M.Sc. Award: Premio di Laurea M. Borsari. Place : University of Bologna (Italy).

- Sep 1987-Jul 88: Master in Business Administration. Place: High School of Marketing Studies. Madrid (Spain).

- Sep 1987-Jul 88: Master in Marketing and Management. Place: High School of Marketing Studies. Madrid (Spain).

- Oct 1982-Jul 88: Licenciatura de grado en Farmacia (M.Sc. in Pharmacy). Final mark: Grado de Sobresaliente (100/100). M.Sc. Award: Premio Extraordinario de Licenciatura. Place: University of Alcalá de Henares (Madrid, Spain). Title of M.Sc. Thesis: “Influencia de la adición de antiespumantes en la producción de antifúngicos por Streptomyces albaduncus en fermentador” (Influence of antifoam addition in the antifungin production of Streptomyces albaduncus in fermentor).





- Jan 1988-Dec 1990: S panish Ph.D. grant from Caja de Ahorros y Monte de Piedad de Madrid (Spain).

- January 1990-Jul 1991: Spanish Ph.D. grant of The Royal College of Spain in Bologna (Italy).

- Sep 1992-Sep 1994: Italian Ph.D. grant (Dottorato di Ricerca) from MURST (Italian Ministry for Universities and Scientific Research).

- Oct-Dec 1994: Research grant from Consorzio Italiano Interuniversitario di Biotecnologie (Italian Inter-university Consortium of Biotechnology).

-    Jan-Dec 1995: Research grant from Italian and Spanish Foreign Ministries.

-    May 1999- May 2001: EC-fellow (level 3) within the EC-framework Biotech-2.



Scientific activity




- Jul 1987 - Jan 1990: Department of Microbiolo­gy and Parasitology. University of Alcalá de Henares (Madrid, Spain).

-    Jan 1990 - Nov 1998: Department of Pharmaceutical Sciences. University of Bologna (Italy).

-    Nov 1988 - October 2012: Department of Industrial Materials Chemistry. University of Bologna (Italy).

-   May 1999 - May 2001: Center for Process Biotechnology. Technical University of Denmark.

-   October 2012 to present: Department of Pharmacy and Biotechnology. University of Bologna (Italy).


Research lines

- Jul 1987 - Dec 1989. Study of a new antifungin compound produced by Streptomyces albaduncus. Direct risponsable for optimization of fermentative production, isolation and purification of active principle.

- Jan 1990 - Jul 1991. 1) Costruction of shuttle vectors derived from native plasmids of thermophilic strains, cloning of such vectors in Bacillus subtillis strains and study of segregational stability during continuous fermentations in nonselective medium. 2) Optimization of lisine fermentative production by mutant NUB3621 of the thermophilic strain Bacillus stearother­mophilus.

- Sep 1991 - Sep 1995. 1) Production of L and D lactic acid stereoisomers by Lactobacillus casei ssp. casei DSM 20011 and Lactobacillus coryniformis ssp. torquens DSM 2004, in batch and continuous fermentation. Study of fermentation paramethers, productivity optimization and mathematic modelling of process. 2) Utilization of NIR spectroscopy in on-line monitoring and control of fermentation processes, using as model the lactic acid fermentation.

-     Oct 1995 - Jul 1996. Determination of optimal culture conditions of Bacillus stearothermophilus NUB 3621, and study of stability of recombinant plasmids during the continuous culture of such strain in nonselective medium. Study of continuous fermentation optimization and plasmid stability on Bacillus stearothermophilus NUB3621.

-         Sep 1995 - Sep 1998. Study of plasmids and fermentative features of the genetically transformable strain Bifidobacterium animalis P-23. Enhancement of biomass production and stability study of several cloning vectors in continuous fermentation.

-         May 1999 - May 2001. Metabolic Engineering of Glycopeptide Antibiotics: Technology, Optimization and Production. An application to the teicoplanin production by Actinoplanes teichomyceticus.

-         2001 – to date. Genetic engineering of Escherichia coli and Bacillus subtillis aimed to the construction of suitable strains useful for the directed evolution of enzymes.

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