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Antonello Lorenzini

Ricercatore confermato

Dipartimento di Scienze Biomediche e Neuromotorie

Settore scientifico disciplinare: BIO/10 BIOCHIMICA

Pubblicazioni

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Pubblicazioni antecedenti il 2004

1) Presentazioni su invito


1) “The relationship between replicative senescence in vitro and aging in vivo: a comparative analysis” at the Department of Biochemistry “G. Moruzzi”, University of Bologna, (Italy) July 6, 2004.

 

2) “The relationship between replicative senescence in vitro and aging in vivo: a comparative analysis” at the Medical School of Pisa University, (Italy) July 14, 2004.

 

3) “A Comparative Approach to Cell Culture to Study Longevity Assuring Mechanisms” at the Claude D. Pepper Older Americans Independence Center Investigators Meeting, Special Lecture Series; Sealy Center on Aging. University of Texas Medical Branch, Galveston TX, (USA), November 1st, 2006

 

4) “Longevity and genome stability across mammals” The Corriel Institute, Camden, New Jersey (USA) January 2007.

 

5) “Nutritional role of Bread” in a WHO and FAO sponsored meeting on bread. Association of Bologna bread makers, Bologna (Italy) Nov, 11, 2007.

 

6) “Dietary Restriction and Aging” San Marino Symposium on  “La Sindrome Metabolica: effetto della nutrizione e dell'esercizio fisico”. 19-20 aprile 2008, San Marino (San Marino).

 

7) “Aging Physical Activity and Sedentariety” 3° Corso Girolamo Mercuriale: Apparato Cardiovascolare e Attività Fisica, Riccione (Italy), 7-9 novembre 2008.

 

8) “Danni al DNA e invecchiamento”, Conferenze “Pacinotti per la Scienza” Incontri con ex studenti organizzati dal Liceo Scientifico Pacinotti di La Spezia, La Spezia, 23 gennaio 2010. Disponibile sul web a: http://www.youtube.com/watch?v=Cjui3E_XEzs

 

9) “Terra 3.0: per uno stile di vita sostenibile”. Primo convengo Nazionale ASAS, Bologna 6 Novembre 2010.

 

 

 

 

2) Curatela testi

 

Life Span Extension: from single cell organism to man.

EDITED BY: Sell, Lorenzini.

HUMANA PRESS, Aging Medicine Series

 

Principi di nutrizione - Nutrizione per lo sport VOLUME 1

EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 

Alimentazione per lo Sport e la Salute - Nutrizione per lo sport VOLUME 2

EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 


3) Capitoli di libro

 

1) Tresini M, Lorenzini A, R. Pignolo, R.G. Allen and Cristofalo V.J.

Senescence and Transformation.

In The Encyclopedia of Aging, Springer Publishing Company, New York. 4th edition (February 1, 2006)

 

2) Antonello Lorenzini

Nutrizione: sfide moderne per una Scienza antica, Chapter 1 in

Principi di nutrizione - Nutrizione per lo sport VOLUME 1

EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 

3) Antonello Lorenzini

Alimentazione nei diversi periodi della vita, Chapter 18 in

Principi di nutrizione - Nutrizione per lo sport VOLUME 1

EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 

4) Lorenzini e Matteoni

Alimenti OGM e Fitoterapia, Chapter 7 in Alimentazione per lo Sport e la Salute - Nutrizione per lo sport VOLUME 2, EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 

5) Lorenzini e Vicino

Allergie e Intolleranze Alimentari, Chapter 12 in Alimentazione per lo Sport e la Salute - Nutrizione per lo sport VOLUME 2, EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 

6) Lorenzini

Invecchiamento e stile di vita, Chapter 13 in Alimentazione per lo Sport e la Salute - Nutrizione per lo sport VOLUME 2, EDITED BY: Biagi - Di Giulio - Fiorilli – Lorenzini

Casa Editrice Ambrosiana, Edizione: 2010

 

 

 


4) Presentazioni a congressi

 

1) A. Lorenzini, S. Hrelia, A. Bordoni and P.L. Biagi.

Relationship between a1-adrenergic response and lipid composition in rat cardiomyocytes aged in culture.

IV National Congress of the Italian Society of Cardiovascular Research. Rimini (Italy), May 22-24, 1997.

 

2)  P.L. Biagi, S. Hrelia, A. Bordoni, A. Lorenzini, C. Spano' and E. Turchetto.

Essential fatty acid metabolism in primary cultures of rat cerdiomyocytes: the effect of aging

SIB: Italian Biochemical Society (Riunione Congiunta), Avellino (Italy) Jun 20-21, 1997.

 

3)  A. Lorenzini, A. Bordoni, D.F. Horrobin, P.L. Biagi and S. Hrelia.

a1-adrenergic response of rat cardiomiocytes aged in culture can be modulated by the manipulation of lipid composition.

Fourth International Congress on Essential Fatty Acids and Eicosanoids, Edinburgh (Scotland), July 20-24, 1997.

 

4)  J.A. Lopez Jimenez, A. Lorenzini, A. Bordoni, P.L. Biagi and S. Hrelia.

Aging influence on linoleic acid metabolism in the heart: a comparative study on two models of cultured cardiomyocytes.

Fourth International Congress on Essential Fatty Acids and Eicosanoids, Edinburgh (Scotland), July 20-24, 1997.

 

5)  S. Hrelia, A. Bordoni, A. Lorenzini and P.L. Biagi.

Impaired response to alpha-1-adrenoceptor stimulation in rat cardiomyocytes aged in culture can be overcome by lipid manipulation.

SIB: Italian Biochemical Society 42th National Congress. Ancona (Italy), September 24-27, 1997.

 

6)  S. Hrelia, A. Lorenzini, A. Bordoni, D.F. Horrobin, and P.L. Biagi.

Gamma-linoleic acid supplementation can modulate the a1-adrenergic response of rat cardiomyocytes aged in culture.

International Conference on the Biochemistry of Lipids, Assisi (Italy), September 16-19, 1997.

 

7)  A. Lorenzini and V.J. Cristofalo

The affect of Arachidonic Acid and the synthetic Ceramide analogues C2, C6, C8 on cell proliferation in WI-38 fibroblasts.

Gordon Research Conference on Biology of Aging: Il Ciocco (Italy), May 10-15, 1998.

 

8)  A. Lorenzini, L. Frisoni, M.K. Francis, Cristofalo V.J.

Activation of the Raf/MEK/ERK pathway is not sufficient for serum-induced c-Fos expression.

Gordon Research Conference on Biology of Aging. Ventura, CA (USA), Jan. 30-Feb. 4, 2000.

 

9)  Lorenzini A, Tresini M, Mawal-Dewan M, Frisoni L,  Zhang H,  Allen RG, Sell C, and CristofaloVJ. Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence. Biological Aging, 2nd Euro Conference on Normal Ageing, Longevity and Age-related Diseases. Spetses, (Greece), May 18-22. 2002.

 

10) Liu Y, Li J, Lorenzini A, Sinogeeva N, Chen P, Gorospe M, Cristofalo V.J.

Constitutively active Raf induces growth arrest in WI-38 Normal Human Lung Fibroblasts: The effect of Active Raf on Chromosomal Structure and gene expression Profiles.

Pediatric Academic Societies Annual Meeting, Seattle, Washington, (USA), May 3-6, 2003

Published in Pediatric Research 53 (4): 275A-275A 1572 Part 2 Suppl. S, Apr. 2003

 

11)  Longevity in Mice Hypomorphic for the Igf1 Allele

A. Lorenzini, R. McCarter, Y. Ikeno, E. Masoro, M. Liu, V. J. Cristofalo, C. Sell

Gerontological Society of America, Annual meeting Washington, Nov. 2004

 

12)  Replicative Senescence can be modulated by alterations in Nuclear MAP Kinase Activity.

M. Tresini, A. Lorenzini, C. Torres, V. J. Cristofalo.

Gerontological Society of America, Annual meeting Washington, Nov. 2004

Published in The Gerontologist, 2004, 44, 14

 

13)  Replicative Senescence and Aging: a Comparative Biology Approach. A. Lorenzini, M. Tresini, M. K. Francis, S. Austad, V. J. Cristofalo.

Gerontological Society of America, Annual meeting Washington, Nov. 2004

Published in The Gerontologist, 2004, 44, 13

 

14)  Replicative Senescence and Aging: a Comparative Biology Approach. A. Lorenzini, M. Tresini, M. K. Francis, S. Austad, V. J. Cristofalo.

American Society of Cell Biology, Annual meeting Washington, Dec. 2004

Published in Molecular Biology of the Cell 15: 93A-93A 515 Suppl. S, Nov. 2004

 

15)  Nuclear MAP Kinase Activity Modulates Replicative Senescence. M. Tresini, A. Lorenzini, C. Torres, V. J. Cristofalo.

American Society of Cell Biology, Annual meeting Washington, Dec. 2004

Published in Molecular Biology of the Cell 15: 94A-94A 519 Suppl. S, Nov. 2004

 

16) Changing fibroblast replicative capacity: role of MAPKs. M. Tresini, A. Lorenzini, C. Torres, V. J. Cristofalo.

Gerontological Society of America, Annual meeting Orlando, Nov. 2005

 

17) A means to a DNA-end. A. Lorenzini, A. Oliver, V. J. Cristofalo, T. Stamato

Gerontological Society of America, Annual meeting Orlando, Nov. 2005

 

18) Increased Longevity in Mice Homozygous for a Hypomorphic Igf-I Allele

Antonello Lorenzini, Marco Malaguti, Roger McCarter, Yuji Ikeno, Edward Masoro, Mantao Liu, Christian Sell.

Nathan Shock Aging Center Conference on Aging: Nutrient Signaling and Aging, San Antonio, Oct. 12-15, 2006

 

19) Evidence that DNA-End Binding Activity is a Key Determinant of Longevity in Mammals.

A. Lorenzini, A. Oliver, V. J. Cristofalo, T. Stamato

Radiation Research Society, 53rd Annual meeting, Philadelphia (USA) Nov. 5-8, 2006.

 

20) Effetti dell'IGF-1 come induttore di stress ossidativo in fibroblasti umani.

M. Malaguti, A. Lorenzini, PL. Biagi,C. Sell.

XXXIV National Congress of the Italian Society for Human Nutrition (SINU) “La Nutrizione Umana Oggi tra Tecnologia e Prevenzione”, Rimini, Italy Nov 8-10. 2006

 

21) I lipidi: come e perche' non temerli

P.L. Biagi e A. Lorenzini

Italian Society for Human Nutrition (SINU) - Italian Biochemical Society (SIB), Incontro di Studio Congiunto, Cesena, Italy, May 31-June 1. 2007

 

22) Correlation of Species Longevity with DNA Double Strand Break-Recognition.

A. Lorenzini.

Riunione Societa' Italiana di Biologia Sperimentale (SIBS) 3-31-2008, Facoltà di Medicina Veterinaria, Ozzano dell'Emilia, Bologna, Italy.

 

23) A. Lorenzini, A. Oliver, M. Tresini, V.J. Cristofalo, M. Malaguti, P. Biagi, S. Hrelia and T.D. Stamato.

Is DNA double strand breaks recognition related to longevity?

53rd National Meeting of Italian Society of Biochemistry and Molecular Biology. 23-26 September 2008, Riccione, Italy. Proceedings in Firenze University Press “Proceedings e report”, 2008, vol 43. p. 86

 

24) Stress-induced senescence in human and rodent astrocytes, Alessandro Bitto, Christian Sell, Elizabeth Crowe, Antonello Lorenzini, Marco Malaguti, Claudio Torres.

Tenth international Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria, July 25-30, 2010. Proceedings in Experimental Gerontology vol. 46, p. 213, 2011.

 

25) Effects of broccoli extract supplementation and physical exercise on antioxidant defences in rat tissues E. Bandini, M. Malaguti, M.Baldini, P.Biagi, S. Hrelia, A. Lorenzini.

 

26) Preconditioning modulates phase II enzymes in cultured cardiomyocytes by Nrf1 and Nrf2 activation. Fabbri D., Angeloni C., Motori E., Leoncini E., Malaguti M., Lorenzini A., Caldarera C.M., Hrelia S. XVIII Congresso Nazionale Società Italiana di Ricerche Cardiovascolari (SIRC) Imola 21-22 Ottobre 2011

 


5) Pubblicazioni Scientifiche (dalla più recente, con link, dove disponibile, all'abstract su PubMed)

 

Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate.

Lorenzini A, Fink LS, Stamato T, Torres C, Sell C.

Aging ( Albany NY ). 2011 Dec;3(12):1206-12.PMID:22201071 [PubMed - in process] Free Article

 

The disposable soma theory revisited: Time as a resource in the theories of aging.

Lorenzini A, Stamato T, Sell C.

Cell Cycle. 2011 Nov 15;10(22):3853-6. Epub 2011 Nov 15.PMID:22071624 [PubMed - in process]

 

53BP1 contributes to a robust genomic stability in human fibroblasts.

Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, Lorenzini A, Sell C.

Aging ( Albany NY ). 2011 Sep;3(9):836-45.PMID:21931182 [PubMed - in process]  Free PMC Article

 

H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation.

Angeloni C, Motori E, Fabbri D, Malaguti M, Leoncini E, Lorenzini A, Hrelia S.

Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2196-205. Epub 2011 Apr 8.PMID:21478407 [PubMed - indexed for MEDLINE]

 

Long-term IGF-I exposure decreases autophagy and cell viability.

Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, Lorenzini A, Hrelia S, Ikeno Y, Matzko ME, McCarter R, Sell C.

PLoS One. 2010 Sep 7;5(9):e12592.PMID:20830296 [PubMed - indexed for MEDLINE]  Free PMC Article

 

Stress-induced senescence in human and rodent astrocytes.

Bitto A, Sell C, Crowe E, Lorenzini A, Malaguti M, Hrelia S, Torres C.

Exp Cell Res. 2010 Oct 15;316(17):2961-8. Epub 2010 Jul 8.PMID:20620137 [PubMed - indexed for MEDLINE]

 

Physical activity and dietary intake in two groups of Italian and Romanian adolescents.

Pasqui F; Baldini M; Lorenzini A, Bordoni A;Malaguti M; Di Carlo M; Miroi R, Maranesi M.

Progress in Nutrition, 2010

 

“7 days for my health” A new tool to evaluate kids' lifestyle

Tiso D, Baldini M, Piaggesi N,Ferrari P, Biagi P, Malaguti M, Lorenzini A.

Agro Food Industry Hi-Tech. 2010: 21:47 - 50.

 

Significant correlation of species longevity with DNA double strand break recognition but not with telomere length.

Lorenzini A, Johnson FB, Oliver A, Tresini M, Smith JS, Hdeib M, Sell C, Cristofalo VJ, Stamato TD.

Mech Ageing Dev. 2009 Nov-Dec;130(11-12):784-92. Epub .PMID:19896964 [PubMed - indexed for MEDLINE]  Free PMC Article

 

Modulation of replicative senescence of diploid human cells by nuclear ERK signaling.

Tresini M, Lorenzini A, Torres C, Cristofalo VJ.

J Biol Chem. 2007 Feb 9;282(6):4136-51. Epub 2006 Dec 4.PMID:17145763 [PubMed - indexed for MEDLINE]  Free Article

 

A critical evaluation of high protein-low carbohydrate diets.

Malaguti M, Hrelia S, Lorenzini A, Biagi P.

Agro Food Industry Hi-Tech. 2007: 5:7 – 8

 

Cellular replicative capacity correlates primarily with species body mass not longevity.

Lorenzini A, Tresini M, Austad SN, Cristofalo VJ.

Mech Ageing Dev. 2005 Oct;126(10):1130-3.PMID:15993927 [PubMed - indexed for MEDLINE]

Article chosen for highlights section

 

Replicative senescence: a critical review.

Cristofalo VJ, Lorenzini A, Allen RG, Torres C, Tresini M.

Mech Ageing Dev. 2004 Oct-Nov;125(10-11):827-48. Review.PMID:15541776 [PubMed - indexed for MEDLINE]

 

Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts.

Torres C, Francis MK, Lorenzini A, Tresini M, Cristofalo VJ.

Exp Cell Res. 2003 Nov 1;290(2):195-206.PMID:14567979 [PubMed - indexed for MEDLINE]

 

Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence.

Lorenzini A, Tresini M, Mawal-Dewan M, Frisoni L, Zhang H, Allen RG, Sell C, Cristofalo VJ.

Exp Gerontol. 2002 Oct-Nov;37(10-11):1149-56.PMID:12470826 [PubMed - indexed for MEDLINE]

 

Regulation of collagenase expression during replicative senescence in human fibroblasts by Akt-forkhead signaling.

Mawal-Dewan M, Lorenzini A, Frisoni L, Zhang H, Cristofalo VJ, Sell C.

J Biol Chem. 2002 Mar 8;277(10):7857-64. Epub 2001 Dec 19.PMID:11751876 [PubMed - indexed for MEDLINE]  Free Article

 

Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.

Tresini M, Lorenzini A, Frisoni L, Allen RG, Cristofalo VJ.

Exp Cell Res. 2001 Oct 1;269(2):287-300.PMID:11570821 [PubMed - indexed for MEDLINE]

 

Is increased arachidonic acid release a cause or a consequence of replicative senescence?

Lorenzini A, Hrelia S, Bordoni A, Biagi P, Frisoni L, Marinucci T, Cristofalo VJ.

Exp Gerontol. 2001 Jan;36(1):65-78.PMID: 11162912[PubMed - indexed for MEDLINE]

 

Insufficient adaptive capability of pancreatic endocrine function in dexamethasone-treated ageing rats.

Novelli M, De Tata V, Bombara M, Lorenzini A, Masini M, Pollera M, Bergamini E, Masiello P.

J Endocrinol. 1999 Sep;162(3):425-32.PMID:10467234 [PubMed - indexed for MEDLINE]  Free Article

 

Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture.

Hrelia S, Pession A, Buda R, Lorenzini A, Horrobin DF, Biagi PL, Bordoni A.

Prostaglandins Leukot Essent Fatty Acids. 1999 Apr;60(4):235-41.PMID:10397404 [PubMed - indexed for MEDLINE]

 

Essential fatty acid metabolism in long term primary cultures of rat cardiomyocytes: a beneficial effect of n-6:n-3 fatty acids supplementation.

Biagi PL, Bordoni A, Lorenzini A, Horrobin DF, Hrelia S.

Mech Ageing Dev. 1999 Mar 1;107(2):181-95.PMID:10220046 [PubMed - indexed for MEDLINE]

 

Dual influence of aging and vitamin B6 deficiency on delta-6-desaturation of essential fatty acids in rat liver microsomes.

Bordoni A, Hrelia S, Lorenzini A, Bergami R, Cabrini L, Biagi PL, Tolomelli B.

Prostaglandins Leukot Essent Fatty Acids. 1998 Jun;58(6):417-20.PMID:10189072 [PubMed - indexed for MEDLINE]

 

Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.

Orlati S, Porcelli AM, Hrelia S, Lorenzini A, Rugolo M.

Biochem J. 1998 Sep 15;334 ( Pt 3):641-9.PMID:9729473 [PubMed - indexed for MEDLINE] Free PMC Article

 

Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation.

Bordoni A, Lorenzini A, Horrobin DF, Biagi PL, Hrelia S.

Biochim Biophys Acta. 1997 Oct 18;1348(3):339-45.PMID:9366250 [PubMed - indexed for MEDLINE]

 

Linoleic acid metabolism in primary cultures of adult rat cardiomyocytes is impaired by aging.

Lopez Jimenez JA, Bordoni A, Lorenzini A, Rossi CA, Biagi PL, Hrelia S.

Biochem Biophys Res Commun. 1997 Aug 8;237(1):142-5.PMID:9266846 [PubMed - indexed for MEDLINE]

 

Age-related changes in essential fatty acid metabolism in cultured rat heart myocytes.

Lorenzini A, Bordoni A, Spanò C, Turchetto E, Biagi PL, Hrelia S.

Prostaglandins Leukot Essent Fatty Acids. 1997 Aug;57(2):143-7.PMID:9250697 [PubMed - indexed for MEDLINE]

 

Essential fatty acid metabolism in cardiomyocytes grown in media enriched with different N-6/N-3 fatty acid combinations.

Hrelia S, Biagi PL, Lorenzini A, Lopez Jimenez JA, Horrobin DF, Bordoni A.

Biochem Mol Biol Int. 1997 Feb;41(2):423-30.PMID:9063583 [PubMed - indexed for MEDLINE]


Modifications of cardiac enzimatic profile in functional overload conditions of the left ventricolum.

Cavallini G, Militello G, Lorenzini A, Giulianotti C, Gori Z, Mosca F, De Tata V.

Il Patologo Clinico 1997; 1:1-3