Santini, Alan; Tassinari, Elisa; Altomare, Alessandra; Loi, Manuela; Ciani, Elisabetta; Trazzi, Stefania; Piccarducci, Rebecca; Daniele, Simona; Martini, Claudia; Pagliarani, Barbara; Tarozzi, Andrea; Bersani, Matteo; Spyrakis, Francesca; Danková, Daniela; Poeta, Eleonora; Raimondi, Simone; Davani, Lara; Aldini, Giancarlo; Andrisano, Vincenza; De Simone, Angela; Milelli, Andrea, AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2025, 296, Article number: 117838 , pp. 1 - 20 [Scientific article]Open Access
Pereira, R. M.; Campos, H. M.; De Oliveira Ferreira, P. Y.; Uchenna, N.; Silva, Y. S.; Okoh, V. I.; Pruccoli, L.; Arruda, E. L.; Liao, L. M.; Mota, P. A. A.; Leite, J. A.; De Castro Georg, R.; Damatta, D.; Dos Santos, F. C. A.; Costa, E. A.; Tarozzi, A.; Menegatti, R.; Ghedini, P. C., Glycosylation of chrysin with β-d-glucose tetraacetate (LQFM280) enhances its in vitro and in vivo neuroprotective effects against the toxicity induced by 3-nitropropionic acid, «NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY», 2025, 398, pp. 4095 - 4109 [Scientific article]Open Access
Di Martino, R. M. C.; Russo, D.; Penna, I.; Demuro, S.; Dalle Vedove, A.; Spagnuolo, R.; Ottonello, G.; Bertozzi, S. M.; Summa, M.; Desantis, J.; Valeri, A.; Pruccoli, L.; Tripathi, S. K.; Tarozzi, A.; Storici, P.; Girotto, S.; Bertorelli, R.; Armirotti, A.; Cruciani, G.; Bandiera, T.; Cavalli, A.; Bottegoni, G., Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2025, 297, Article number: 117899 , pp. 1 - 31 [Scientific article]Open Access
Mesquita Campos, Hericles; Mota Pereira, Robbert; Yasmin de Oliveira Ferreira, Pamela; Uchenna, Nkaa; Rio Branco da Silva, Cínthia; Pruccoli, Letizia; Sanz, German; Ferreira Rodrigues, Marcella; Gontijo Vaz, Boniek; Gonçalves Rivello, Barbara; Luís Batista da Rocha, Andre; Silva de Carvalho, Flavio; de Almeida Ribeiro Oliveira, Gerlon; Morais Liao, Luciano; de Castro Georg, Raphaela; Alves Leite, Jacqueline; Cristina Alcantara dos Santos, Fernanda; Alves Costa, Elson; Menegatti, Ricardo; Tarozzi, Andrea; Cesar Ghedini, Paulo, A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models, «CHEMICO-BIOLOGICAL INTERACTIONS», 2024, 395, Article number: 111026 , pp. 1 - 10 [Scientific article]Open Access
Pruccoli, Letizia; Nicolini, Benedetta; Lianza, Mariacaterina; Teti, Gabriella; Falconi, Mirella; Tarozzi, Andrea; Antognoni, Fabiana, Antioxidant and Anti-Melanogenesis Effects of Teucrium chamaedrys L. Cell Suspension Extract and Its Main Phenylethanoid Glycoside in B16-F10 Cells, «PLANTS», 2024, 13, Article number: 808 , pp. 1 - 9 [Scientific article]Open Access
Pruccoli, Letizia; Balducci, Martina; Pagliarani, Barbara; Tarozzi, Andrea, Antioxidant and Neuroprotective Effects of Fucoxanthin and Its Metabolite Fucoxanthinol: A Comparative In Vitro Study, «CURRENT ISSUES IN MOLECULAR BIOLOGY», 2024, 46, pp. 5984 - 5998 [Scientific article]Open Access
Ifeanyi Okoh, Victor; Mesquita Campos, Hericles; Yasmin de Oliveira Ferreira, Pâmela; Mota Pereira, Robbert; Souza Silva, Yohanny; Lima Arruda, Evilanna; Pagliarani, Barbara; de Almeida Ribeiro Oliveira, Gerlon; Morais Lião, Luciano; Franco Dos Santos, Gabriel; Gontijo Vaz, Boniek; Ricardo Sabino, José; Cristina Alcantara Dos Santos, Fernanda; Alves Costa, Elson; Tarozzi, Andrea; Menegatti, Ricardo; César Ghedini, Paulo, Chrysin bonded to β-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice, «JOURNAL OF PHARMACY AND PHARMACOLOGY», 2024, 76, pp. 368 - 380 [Scientific article]Open Access
Balducci, M.; Perez, J. T.; del Rio, C. T.; Perez, M. C.; Carranza, A. D. V.; Gomez Escribano, A. P.; Vazquez-Manrique, R. P.; Tarozzi, A., Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2024, 25, Article number: 12220 , pp. 1 - 13 [Scientific article]Open Access
Santini, A.; Tassinari, E.; Poeta, E.; Loi, M.; Ciani, E.; Trazzi, S.; Piccarducci, R.; Daniele, S.; Martini, C.; Pagliarani, B.; Tarozzi, A.; Bersani, M.; Spyrakis, F.; Danková, D.; Olsen, C. A.; Soldati, R.; Tumiatti, V.; Montanari, S.; De Simone, A.; Milelli, A., First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease, «ACS CHEMICAL NEUROSCIENCE», 2024, 15, pp. 2099 - 2111 [Scientific article]Open Access
De Freitas Silva, Matheus; Juliet Cristancho Ortiz, Cindy; Ferreira Coelho, Letícia; Pruccoli, Letizia; Pagliarani, Barbara; Pisani, Leonardo; Catto, Marco; Poli, Giulio; Tuccinardi, Tiziano; Cardoso Vilela, Fabiana; Giusti-Paiva, Alexandre; Amaral Alves, Marina; Ribeiro De Souza, Hygor M.; Tarozzi, Andrea; Silva Gontijo, Vanessa; Jr., Claudio Viegas, Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease, «BIOORGANIC CHEMISTRY», 2024, 150, Article number: 107587 , pp. 1 - 18 [Scientific article]Open Access
Balducci M.; Pruccoli L.; Tarozzi A., Heat stress as a potential risk factor for vitamin D deficiency, «MEDICAL HYPOTHESES», 2023, 176, Article number: 111085 , pp. 1 - 3 [Scientific article]Open Access
Tarozzi A.; Angeloni C., Neuroprotection by Drugs, Nutraceuticals and Physical Activity, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2023, 24, Article number: 3176 , pp. 1 - 7 [Scientific article]Open Access
Guardigni M.; Pruccoli L.; Santini A.; Simone A.D.; Bersani M.; Spyrakis F.; Frabetti F.; Uliassi E.; Andrisano V.; Pagliarani B.; Fernández-Gómez P.; Palomo V.; Bolognesi M.L.; Tarozzi A.; Milelli A., PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease, «ACS CHEMICAL NEUROSCIENCE», 2023, 14, pp. 1963 - 1970 [Scientific article]Open Access
De Lorenzi, Ersilia; Seghetti, Francesca; Tarozzi, Andrea; Pruccoli, Letizia; Contardi, Cecilia; Serra, Massimo; Bisi, Alessandra; Gobbi, Silvia; Vistoli, Giulio; Gervasoni, Silvia; Argentini, Carla; Ghirardo, Giulia; Guarato, Giulia; Orso, Genny; Belluti, Federica; Di Martino, Rita Maria Concetta; Zusso, Morena, Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2023, 252, Article number: 115297 , pp. 1 - 15 [Scientific article]Open Access
Andreev S.; Pantsar T.; Tesch R.; Kahlke N.; El-Gokha A.; Ansideri F.; Gratz L.; Romasco J.; Sita G.; Geibel C.; Lammerhofer M.; Tarozzi A.; Knapp S.; Laufer S.A.; Koch P., Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors, «JOURNAL OF MEDICINAL CHEMISTRY», 2022, 65, pp. 1283 - 1301 [Scientific article]Open Access
