Argomenti di tesi proposti dal docente.
DESIGN AND INVESTIGATIONS ON THE CHEMISTRY, STRUCTURAL DETERMINATION, DFT THEORETICAL INSIGHTS ON NOVEL COMPOUNDS ON Ru(II) SPECIES BEARING BIOACTIVE MOLECULES WITH POTENTIAL PHARMACEUTICAL ACTIVITY
The main point is the development and validation of technologies with methods that make possible to face the current challenges to cope with a modern medicine vision. To date, there are several factors that lead to disability, morbility or mortality, reduction of years of life, due to diseases developed in adulthood, including CANCER or ANTIBACTERIAL RESISTANCE. The implementation of new therapies is a global challenge, that Health Care Institutions will need to face to achieve one of the objectives of the OMS, aiming to reduce the early mortality, due to non-communicable diseases within 2030. New therapeutic targets, which consider as innovative drugs the molecular features shown by the patient’s individual pathologies, must be first identified and characterized; thus the holistic information will be used to promote various applications into the personalized therapies. Further, it is undoubtedly evident that the climate crisis with the increasing exposure to cancerogenic agents has nowadays a greater health impact by enhancing cancer risk factors, due to extreme events to promote fast human being changing or by often hindering Care Access not only in the overexposed countries, but unexpectedly inside unimaginable places, showing commonly recognized temperate climate .
the Ru(II) metal skeleton induces anticancer properties. The research will be focused on developing a targeted therapy, with improved delivery and effectiveness, along with antitumor structure-activity behaviour and the proposed plausible mechanistic paths. The reactions are going to be optimized, from the point of view of reaction conditions to minimize energy expenditure and running experimental procedures by greener means.
We keep on exploring new metal drugs design incorporating imino-molecules as Schiff bases with a special sight to that bearing pyridine and salicylic acid as substituents. The reactions gave unexpected reactivity and showed different synthetic mechanistic paths which worth to have further investigations to optimize the procedures by changing solvents or reaction conditions to direct the synthesis towards higher selectivity
From previous exploitations on metal coordination of aminoacid as asparagine, hydroxytryptophan, tyrosine and homocysteine we found that the Ru(II)-grafted aminoacids exhibit interesting antibacterial aptitudes. So, we plan to investigate further Ru-coordination with essential and non-essential amino-acid to exploring their potential applications as antibacterial to cope the increasing resistance of antibiotics. Further we intend to exploit the possible synthetic methodology to afford metal-coordinating under-investigated molecules like psilocin to be used to indirectly stimulating well-known neuromodulators like serotonin to seek novel applications as antiobesity or anticancer innovative remedies.
Currently we plan to extend our research in coordinating different Schiff bases with special sight on the salicylate-pyridine moieties as substituents of imine functional group affording a k2- dihapto-(N,N) or (N,O) or k3-trihapto-(O,N,N) chelation, depending on the solvent and the reaction conditions. The topic is remarkably appealing because they show evident antineoplastic effect as recently reported in the literature. The current research field presents the synthesis with moderate to good yields, structural elucidation, and biological studies of novel Ru(II) complexes with potential anticancer and antimicrobial applications.
