Foto del docente

Rosaria Spagnuolo

Dottoranda

Dipartimento di Farmacia e Biotecnologie

Tutor didattico

Dipartimento di Farmacia e Biotecnologie

Settore scientifico disciplinare: CHIM/08 CHIMICA FARMACEUTICA

Pubblicazioni

Hassan, N. W.; Afifi, O. S.; El-Attar, M. A. Z.; Kamel, Y. N.; Yassin, H. A.; Nomeir, H. M.; Angeli, A.; Labib, H. F.; Elsheikh, M. A.; Zewail, M.; Gerges, E. M.; El-Yazbi, A. F.; Spagnuolo, R.; Naldi, M.; Ashmawy, M. I.; Zahra, W. K.; Hammad, S. F.; Supuran, C. T.; Bartolini, M.; Elzahhar, P. A.; Belal, A. S. F.; Abd El Wahab, S. M., One destination, three routes: Tacrine-Celecoxib hybrids targeting cholinesterases, COX-2, and carbonic anhydrases in cognitive impairment linked to metabolic dysfunction, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2026, 315, Article number: 118984, pp. 1 - 22 [articolo]

Osman, Shams T.; Elzahhar, Perihan A.; Hakim, Md Abdul; Sanni, Akeem; Hamdy, Noha A.; Purba, Waziha Tasnim; Bhuiyan, Md Mostofa Al Amin; Onigbinde, Sherifdeen; Sandilya, Vishal; Hassan, Nayera W.; Agami, Mahmoud; El‐khordagui, Labiba K.; Spagnuolo, Rosaria; Naldi, Marina; Bartolini, Manuela; Belal, Ahmed S. F.; Mechref, Yehia S.; El‐yazbi, Ahmed F., Repurposing SGLT2 and DPP‐4 inhibitors for mild cognitive impairment in type 2 diabetes mellitus: Insights from proteomics, target prediction and molecular docking, «BRITISH JOURNAL OF PHARMACOLOGY», 2026, 183, pp. 2533 - 2555 [articolo]

Verano, Aldrick B.; Sampietro, Anna; Mallo-Abreu, Ana; Spagnuolo, Rosaria; Pérez, Belén; Bartolini, Manuela; Loza, María Isabel; Brea, José; Juárez-Jiménez, Jordi; Sabate, Raimon; Galdeano, Carles; Muñoz-Torrero, Diego, Synthesis and Biological Profiling of New 1,2,3,4-Tetrahydrobenzo[h]naphthyridine-Based Hybrids as Dual Inhibitors of β-Amyloid and Tau Aggregation with Anticholinesterase Activity, «BIOMOLECULES», 2026, 16, Article number: 593, pp. 1 - 32 [articolo]Open Access

Orioli, R.; Sarno, G.; Seghetti, F.; Gobbi, S.; Belluti, F.; Feoli, A.; Massenzio, F.; Monti, B.; Spagnuolo, R.; Bartolini, M.; Castellano, S.; Bisi, A., Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2025, 295, pp. 117799 - 117816 [articolo]Open Access

Elzahhar, Perihan A.; Nematalla, Hisham A.; Abouayana, Malak A.; El Ashry, El Sayed H.; Balbaa, Mahmoud; Petreni, Andrea; Nassra, Rasha; Yassin, Hend A.; Kamel, Yasmine N.; Elrewiny, Mohamed A.; Agami, Mahmoud A.; Makkar, Monica; Sai, Minh; Merk, Daniel; Labib, Hala F.; Spagnuolo, Rosaria; Naldi, Marina; Bartolini, Manuela; El-Hawash, Soad A.; Supuran, Claudiu T.; Belal, Ahmed S. F.; El-Yazbi, Ahmed F., Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction, «ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE», 2025, 8, pp. 1627 - 1658 [articolo]

Di Martino, R. M. C.; Russo, D.; Penna, I.; Demuro, S.; Dalle Vedove, A.; Spagnuolo, R.; Ottonello, G.; Bertozzi, S. M.; Summa, M.; Desantis, J.; Valeri, A.; Pruccoli, L.; Tripathi, S. K.; Tarozzi, A.; Storici, P.; Girotto, S.; Bertorelli, R.; Armirotti, A.; Cruciani, G.; Bandiera, T.; Cavalli, A.; Bottegoni, G., Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2025, 297, Article number: 117899, pp. 1 - 31 [articolo]Open Access

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