Expression and functional analysis of human genes associated to
complex diseases An integrated approch of bioinformatics,
molecular genetics and functional genomics will be used to an
extensive study of human gene with known function or to
characterize unknown function ones. Results could be useful to
better understand molecular biology and genetic of the associated
complex diseases. Functional analysis is made using the vertebrate
animal model zebrafish (Danio rerio).
Parkinson disease: an integrated study of functional
genomic and pathological phenotype The research aims to
identify chromosomal regions that show a consistent and stable
alteration in gene expression associated with Parkinson's disease
(PD), as a final effect of genetic and epigenetic mechanisms of
regulation. The integrated approach of studies between functional
genotype and pathological phenotype, enable us to understand the
pathogenetic mechanisms that lead to neurodegeneration and
neuroinflammation in in vitro models of PD. The short-term goals
are to identify specific genes altered in PD, while long-term
results can contribute to the development of new neuroprotective
drugs.
