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Noah Moruzzi

Adjunct professor

Department of Pharmacy and Biotechnology

Publications

Scientific Publications

  1. Metabolic profiling reveals a glycolytic shift and an IRG1/itaconate/NF2L2 axis regulating neurotoxic oxidative stress in inflammatory microglia. Pinelopi Engskog-Vlachos, Mikael Engskog, Martin Skandik, Kathleen Grabert, Noah Moruzzi, Marie-Kim St-Pierre, Ahmed Osman, Theodora Sylaidi, Per-Olof Berggren and Bertrand Joseph. J Neurochem, 2025, Sep;169(9):e70219. doi: 10.1111/jnc.70219.
  2. Metabolic Profiling of Distinct TP53-Mutant Esophageal Adenocarcinoma Models Reveals Different Bioenergetic Dependencies. Erica Cataldi-Stagetti, Nicola Rizzardi, Arianna Orsini, Bianca De Nicolo, Chiara Diquigiovanni, Luca Pincigher, Noah Moruzzi, Romana Fato, Christian Bergamini and Elena Bonora. Int J Mol Sci, 2025 Jul 17;26(14):6869. doi: 10.3390/ijms26146869.
  3. In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye. Francesca Lazzeri-Barcelo, Pierpaolo Ciardo, Barbara Leibiger, Ingo B. Leibiger, Per-Olof Berggren#, Noah Moruzzi#*. J Vis Exp, 2024, Mar 29:(205). doi: 10.3791/66234.
  4. Ruxolitinib: A New Hope For Ventilator Induced Diaphragm Dysfunction. Alex B. Addinsall, Niccola Cacciani, Noah Moruzzi, Hazem Akkad, Alice Maestri, Per-Olof Berggren, Ganna Shevchenko, Jonas Bergquist, Tamara Tchkonia, James L. Kirkland and Lars Larsson. Acta Physiol (Oxf), 2024, Mar 29:e14128. doi: 10.1111/apha.14128.
  5. Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function. Francesca Lazzeri-Barcelo, Nuria Olivia-Vilarnau, Marion Baniol, Barbara Leibiger, Olaf Bergmann, Volker M. Lauschke, Ingo B. Leibiger, Noah Moruzzi *# and Per-Olof Berggren#. Nat Commun 15, 767 2024. doi: 10.1038/s41467-024-45122-4
  6. Mitochondrial bioenergetics impairments in genetic and metabolic diseases. Christian Bergamini #, Elena Bonora # and Noah Moruzzi #. Front. Physiol, 2023, 14,https://doi.org/10.3389/fphys.2023.1228926.
  7. Novel aspect of intra-islet communication: Primary cilia and filopodia. Noah Moruzzi *, Christopher J Barker, Barbara Leibiger, Ingo B Leibiger, Per-Olof Berggren. Adv Biol Regul, 2022, 2212-4934, 10.1016/j.jbior.2022.100919.
  8. Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells. Uma D Kabra, Noah Moruzzi, Per-Olof Berggren and Martin Jastroch. IJMS, 2022, 23(20), 12338; https://doi.org/10.3390/ijms232012338
  9. Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology. Noah Moruzzi*, Ismael Valladolid-Acebes, Sukanya Kannabiran, Sara Bulgaro, Ingo Burtscher, Barbara Leibiger, Ingo Leibiger, Per-Olof Berggren, Kerstin Brismar. Life Sci Alliance, 2022 Sep 14;5(12):e202201505. doi: 10.26508/lsa.202201505. PMID: 36104081
  10. Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells. Rasool Saghaleyni, Magdalena Malm, Noah Moruzzi, Jan Zrimec, Ronia Razavi, Num Wistbacka, Hannes Thorell, Anton Pintar, Andreas Hober, Fredrik Edfors, Veronique Chotteau, Per-Olof Berggren, Luigi Grassi, Aleksej Zelezniak, Thomas Svensson, Diane Hatton, Jens Nielsen, Jonathan L Robinson, Johan Rockberg. Cell reports, 2022. Jun 14;39(11):110936. doi: 10.1016/j.celrep.2022.110936. PMID: 35705050
  11. Insulin receptor isoforms in physiology and metabolic disease. Noah Moruzzi* and Francesca Lazzeri-Barcelo. IntechOpen Chapter 2021 MarDOI: 10.5772/intechopen.103036
  12. Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells. Kim Olesen#, Noah Moruzzi#, Ivana Bulatovic, Clifford Folmes, Ryounghoon Jeon, Ulrika Felldin, Andre Terzic, Oscar E Simonson, Katarina Le Blanc, Cecilia Österholm, Per-Olof Berggren, Tomas Schiffer, Sergey Rodin, Andreas Tilevik, Karl-Henrik Grinnemo. Metabol Open 2022 Feb 3;13:100167. doi: 10.1016/j.metop.2022.100167. PMID: 35528374
  13. An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation. Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjöld, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin & Roman A. Zubarev. Nat Commun 12, 6558 2021. doi: 10.1038/s41467-021-26879-4. PMID: 34772928
  14. Tissue-specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models. Noah Moruzzi*, Francesca Lazzeri-Barcelo, Ismael Valladolid-Acebes, Tilo Moede, Meike Paschen, Barbara Leibiger, Per-Olof Berggren, Ingo B Leibiger. J Cell Mol Med. 2021 May;25(10):4800-4813. doi: 10.1111/jcmm.16452. PMID: 33742502
  15. Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements. Ismael Valladolid-Acebes, Karin Åvall, Patricia Recio-López, Noah Moruzzi, Galyna Bryzgalova, Marie Björnholm, Anna Krook, Elena Fauste Alonso, Madelene Ericsson, Fredrik Landfors, Stefan K Nilsson, Per-Olof Berggren, Lisa Juntti-Berggren Sci Adv. 2021 Mar 12;7(11):eabc2931. doi: 10.1126/sciadv.abc2931. PMID: 33712458
  16. Platelet factor 4 enhances CD4+T effector memory cell responses via Akt-PGC1α-TFAM signalling-mediated mitochondrial biogenesis. Shuai Tan, Shuijie Li, Yanan Min, Anton Gisterå, Noah Moruzzi, Junhao Zhang, Yang Sun, John Andersson, Rickard E Malmström, Miao Wang, Per-Olof Berggren, Susanne Schlisio, Wangjun Liao, Daniel F J Ketelhuth, Chunhong Ma, Nailin Li. J Thromb Haemost. 2020 Oct;18(10):2685-2700. doi: 10.1111/jth.15005. PMID: 32671959
  17. miR-31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome. Alina Johansson, William A Nyberg, Maria Sjöstrand, Noah Moruzzi, Petra Bergman, Mohsen Khademi, Magnus Andersson, Fredrik Piehl, Per-Olof Berggren, Ruxandra Covacu, Maja Jagodic, Alexander Espinosa Eur J Immunol. 2019 Feb;49(2):313-322. doi: 10.1002/eji.201747416. PMID: 30307034
  18. Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass. Meike Paschen, Tilo Moede, Ismael Valladolid-Acebes, Barbara Leibiger, Noah Moruzzi, Stefan Jacob, Concha F García-Prieto, Kerstin Brismar, Ingo B Leibiger, Per-Olof Berggren FASEB J. 2019 Jan;33(1):204-218. doi: 10.1096/fj.201800826R. PMID: 29957055
  19. Role of Mitochondrial Complex I and Protective Effect of CoQ10 Supplementation in Propofol Induced Cytotoxicity. Christian Bergamini, Noah Moruzzi, Francesco Volta, Laura Faccioli, Jantje Gerdes, Maria Cristina Mondardini, Romana Fato. Journal of Bioenergetics. 2016 Aug;48(4):413-23. doi: 10.1007/s10863-016-9673-9. PMID: 27525823
  20. Identification of Proliferative and Mature β-cells in the Islet of Langerhans. Erik Bader, Adriana Migliorini, Moritz Gegg, Noah Moruzzi, Jantje Gerdes, Sara S Roscioni, Mostafa Bakhti, Elisabeth Brandl, Martin Irmler, Johannes Beckers, Michaela Aichler, Annette Feuchtinger, Christin Leitzinger, Hans Zischka, Rui Wang-Sattler, Martin Jastroch, Matthias Tschöp, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Helena Chmelova, Julie A Chouinard, Nikolay Oskolkov, Olle Korsgren, Stephan Speier, Heiko Lickert. Nature. 2016 Jul 21;535(7612):430-4. doi: 10.1038/nature18624. PMID: 27398620
  21. Ciliary Dysfunction Impairs β-cells Insulin Secretion and Promotes Development of Type 2 Diabetes in Rodents. Jantje M Gerdes, Sonia Christou-Savina, Yan Xiong, Tilo Moede, Noah Moruzzi, Patrick Karlsson-Edlund, Barbara Leibiger, Ingo B Leibiger, Claes-Göran Östenson, Philip L Beales, Per-Olof Berggren. Nature Commun. 2014 Nov 6;5:5308. doi: 10.1038/ncomms6308. PMID: 25374274
  22. Short and Prolonged Exposure to Hyperglycaemia in Human Fibroblasts and Endothelial Cells: Metabolic and Osmotic Effects. Noah Moruzzi*, Marianna Del Sole, Romana Fato, Jantje M Gerdes, Per-Olof Berggren, Christian Bergamini, Kerstin Brismar. Int. J. Biochem. Cell Biol. 2014 Aug;53:66-76. doi: 10.1016/j.biocel.2014.04.026. PMID: 24814290
  23. Hyperoxia Inhibits Glucose-induced Insulin Secretion and Mitochondrial Metabolism in Rat Pancreatic Islets. Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Valdemar Grill, Anneli Björklund. Biochem. Biophys. Res. Commun. 2014 Jan 3;443(1):223-8. doi: 10.1016/j.bbrc.2013.11.088. PMID: 24299957
  24. Preconditioning with Associated Blocking of Ca2+ Inflow Alleviates Hypoxia-induced Damage to Pancreatic β-cells. Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Ingrid Hals, José Oberholzer, Valdemar Grill, Anneli Björklund. Plos One. 2013 Jul 25;8(7):e67498. doi: 10.1371/journal.pone.0067498. PMID: 23935835
  25. A Water Soluble CoQ10 Formulation Improves Intracellular Distribution and Promotes Mitochondrial Respiration in Cultured Cells. Christian Bergamini, Noah Moruzzi, Antonella Sblendido, Giorgio Lenaz, Romana Fato. Plos One. 2012;7(3):e33712. doi: 10.1371/journal.pone.0033712. PMID: 22432044

Corresponding author *

Equal contribution #

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