Medici, Giorgio; Bove, Angelica M.; Trazzi, Stefania; Puppo, Francesca; Loi, Manuela; Mottolese, Nicola; Candini, Giulia; Trebbi, Federica; Sanchez, Sandra; Muotri, Alysson R.; Ciani, Elisabetta, A cross-correction gene therapy approach for CDKL5 deficiency disorder improves the pathological phenotype of CDD patient-derived cortical organoids, «FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY», 2025, 13, Article number: 1744903 , pp. 1 - 16 [Scientific article]
Mottolese, Nicola; Iannibelli, Feliciana; Candini, Giulia; Trebbi, Federica; Loi, Manuela; Bove, Angelica Marina; Medici, Giorgio; Xiong, Zhi-Qi; Ciani, Elisabetta; Trazzi, Stefania, Adult-Onset Deletion of CDKL5 in Forebrain Glutamatergic Neurons Impairs Synaptic Integrity and Behavior in Mice, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2025, 26, Article number: 6626 , pp. 1 - 26 [Scientific article]Open Access
Loi, Manuela; Valenti, Francesca; Medici, Giorgio; Mottolese, Nicola; Candini, Giulia; Bove, ANGELICA MARINA; Trebbi, Federica; Pincigher, Luca; Fato, Romana; Bergamini, Christian; Trazzi, Stefania; Ciani, Elisabetta, Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2025, 26, Article number: 2204 , pp. 1 - 23 [Scientific article]Open Access
Medici, Giorgio; Candini, Giulia; Mottolese, Nicola; Uguagliati, Beatrice; Trebbi, Federica; Loi, Manuela; Bove, Angelica Marina; Stojanov, Spase; Esposito, Erika; Vitagliano, Rosalba; D'Amico, Federica; Turroni, Silvia; Fiori, Jessica; Berlec, Aleš; Trazzi, Stefania; Ciani, Elisabetta, Lactic acid bacteria as microbial cell factories for the in vivo delivery of therapeutic proteins as secretable TAT fusion products, «JOURNAL OF BIOLOGICAL ENGINEERING», 2025, 19, Article number: 65 , pp. 1 - 17 [Scientific article]Open Access
Medici, Giorgio; Tassinari, Marianna; Loi, Manuela; Bove, Angelica Marina; Garofani, Beatrice Casadei; Volpedo, Greta; Mottolese, Nicola; Matteoli, Gabriele; Lo Martire, Viviana; Berteotti, Chiara; Candini, Giulia; Trebbi, Federica; Riva, Antonella; Striano, Pasquale; Zoccoli, Giovanna; Curia, Giulia; Trazzi, Stefania; Ciani, Elisabetta, Safety and efficacy of Igk-TATk-CDKL5 gene therapy in mosaic CDKL5 deficiency, «NEUROTHERAPEUTICS», 2025, 22, Article number: e00727 , pp. 1 - 19 [Scientific article]Open Access
Mottolese N.; Coiffard O.; Ferraguto C.; Manolis A.; Ciani E.; Pietropaolo S., Autistic-relevant behavioral phenotypes of a mouse model of cyclin-dependent kinase-like 5 deficiency disorder, «AUTISM RESEARCH», 2024, 17, pp. 1742 - 1759 [Scientific article]
Mottolese, Nicola; Loi, Manuela; Trazzi, Stefania; Tassinari, Marianna; Uguagliati, Beatrice; Candini, Giulia; Iqbal, Khalid; Medici, Giorgio; Ciani, Elisabetta, Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder, «JOURNAL OF NEURODEVELOPMENTAL DISORDERS», 2024, 16, Article number: 65 , pp. 1 - 19 [Scientific article]Open Access
Loi, Manuela; Bastianini, Stefano; Candini, Giulia; Rizzardi, Nicola; Medici, Giorgio; Papa, Valentina; Gennaccaro, Laura; Mottolese, Nicola; Tassinari, Marianna; Uguagliati, Beatrice; Berteotti, Chiara; Martire, Viviana Lo; Zoccoli, Giovanna; Cenacchi, Giovanna; Trazzi, Stefania; Bergamini, Christian; Ciani, Elisabetta, Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2023, 24, Article number: 5552 , pp. 5552 - 5577 [Scientific article]Open Access
Tassinari, Marianna; Uguagliati, Beatrice; Trazzi, Stefania; Cerchier, Camilla Bruna; Cavina, Ottavia Vera; Mottolese, Nicola; Loi, Manuela; Candini, Giulia; Medici, Giorgio; Ciani, Elisabetta, Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder, «NEUROBIOLOGY OF DISEASE», 2023, 182, Article number: 106146 , pp. 1 - 14 [Scientific article]Open Access
Mottolese, Nicola; Uguagliati, Beatrice; Tassinari, Marianna; Cerchier, Camilla Bruna; Loi, Manuela; Candini, Giulia; Rimondini, Roberto; Medici, Giorgio; Trazzi, Stefania; Ciani, Elisabetta, Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder, «BIOMOLECULES», 2023, 13, Article number: 1396 , pp. 1 - 19 [Scientific article]Open Access
Medici, Giorgio; Tassinari, Marianna; Galvani, Giuseppe; Bastianini, Stefano; Gennaccaro, Laura; Loi, Manuela; Mottolese, Nicola; Alvente, Sara; Berteotti, Chiara; Sagona, Giulia; Lupori, Leonardo; Candini, Giulia; Baggett, Helen Rappe; Zoccoli, Giovanna; Giustetto, Maurizio; Muotri, Alysson; Pizzorusso, Tommaso; Nakai, Hiroyuki; Trazzi, Stefania; Ciani, Elisabetta, Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder, «NEUROTHERAPEUTICS», 2022, 19, pp. 1886 - 1904 [Scientific article]Open Access
Tassinari, Marianna; Mottolese, Nicola; Galvani, Giuseppe; Ferrara, Domenico; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Candini, Giulia; Rimondini, Roberto; Ciani, Elisabetta; Trazzi, Stefania, Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2022, 23, Article number: 8719 , pp. 1 - 23 [Scientific article]Open Access
Fuchs, Claudia; Cosentino, Livia; Urbinati, Chiara; Talamo, Maria Cristina; Medici, Giorgio; Quattrini, Maria Cristina; Mottolese, Nicola; Pietraforte, Donatella; Fuso, Andrea; Ciani, Elisabetta; De Filippis, Bianca, Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder, «CNS NEUROSCIENCE & THERAPEUTICS», 2022, 28, pp. 1718 - 1732 [Scientific article]Open Access
Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari, Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania, Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder, «JOURNAL OF NEUROINFLAMMATION», 2021, 18, Article number: 155 , pp. 1 - 21 [Scientific article]Open Access
Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Giuseppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta, Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2021, 22, Article number: 5950 , pp. 1 - 24 [Scientific article]Open Access
