Maria Maddalena Calabretta

Senior assistant professor (fixed-term)

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/01 Analytical Chemistry

Research

Keywords: Bio-Chemiluminescence Whole-cell biosensors Bioanalytical Chemistry 3D cell culture models Portable analytical devices Analytical Chemistry Point-of-Care devices Point-of-need devices Portable light detectors (CCD, CMOS, SipM, Smartphone)

Development ultrasensitive analytical methods with bio- and chemiluminescence detection applied to biomedical and pharmaceutical screening (HTS and HCS), environmental and food
Development of portable and new miniaturized biosensing devices for on-site multiplexed analysis
Development of bioluminescent cell-based assays and whole-cell biosensors for the quantification of endocrine disruptors, new molecules and toxic compounds in biological, environmental and clinical samples.
Implementation of bioluminescent 3D whole-cell biosensors into portable analytical devices for analysis of clinic samples and drug screening
Development of colorimetric chemosensor and enzymatic biosensor for food spoilage monitoring
Development of new in vitro Bioluminescence Resonance Energy Transfer (BRET) assays and Protein-Complementation Assay (PCA) for monitoring protein-protein interactions
In vitro Bioluminescence Imaging and development of Bioluminescent 3D cell culture models.
Cloning, random and site-directed mutagenesis of new bioluminescent proteins and photoproteins with improved emission properties and thermo- and pH-stability

Maria Maddalena Calabretta

Research

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