Foto del docente

Marco Lombardo

Associate Professor

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/06 Organic Chemistry


Keywords: bioactive molecules organometallic chemistry ionic liquids organocatalysis stereocontrolled reactions

The experience of the research group in applied organic chemistry and sustainable approaches to organic synthesis is now focused on the following topics:

  • Design and application of new organometallic reagents to organic synthesis.
  • Synthesis of bioactive molecules.
  • Design and development of new sustainable synthetic processes.
  • Preparation and use of new ion-tagged catalysts in organocatalysis and in metal-catalyzed processes.

  • Design and development of new organometallic reagents. A novel class of alfa-hydroxyallylating agents developed in our lab will be applied to the total synthesis of bioactive molecules, such as fungicides and antibiotics.
  • Synthesis of bioactive molecules. A new class of molecules with endoperoxide moiety have been synthesized and are currently under study for their potential activity as new antimalarial drugs.
  • New sustainable chemical processes. Known syntheses will be re-examined on the basis of eco-compatibility concepts. The reduction of energy consumption by using microwave heating, the reduction of chemical wastes by adopting solvent-less conditions or water as solvent, the use of ionic liquids as non volatile solvents are examples of technologies under development in our lab.
  • Design and synthesis of ion tagged catalysts in organocatalysis and in metal-promoted catalysis. Over the last two years the most explored field in our lab was the design of metal-based catalysts and organocatalysts capable to work under sustainable conditions, e.g. in ionic liquids, in water or in aqueous biphasic conditions. Our strategy involves the installation of a permanent ionic group into the skeleton of known catalysts in such a way to combine efficiency and stereoselectivity with the catalyst recyclability, ensured by an efficient trapping of the catalyst in the ionic liquid or aqueous phase.

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