Foto del docente

Marco Candela

Professore associato

Dipartimento di Farmacia e Biotecnologie


Temi di ricerca

Parole chiave: Microbiota Intestinale Coevoluzione Ecologia Microbica

Role of the human intestinal microbiota in the biology of the mammalian metaorganism, an evolutionary perspective

Symbiont microbial communities had a role of primary importance in the mammalian evolution. Conferring a high degree of plasticity to the host organism, microbial communities represent strategic drivers of the metaorganism adaptive processes. In this scenario, our research activity is aimed to explore the mechanism involved in microbe-host co-evolution dynamics. Approaches of genomics, metabolomics, culturomics and system biology are applied to this purpose, allowing to dissect how intestinal microbes (gut microbiota) complement the host phenotype, conferring essential physiological features for the host biology.

Role of microbial ecosystems in holobionts populating soil and marine environments

Recent advance in genomics and molecular microbiology shed lights on the importance of symbiont microbial communities on the biology of several organisms, recently revised as holobionts, being the result of a close interaction with hosted bacterial communities (microbiota). Potentially, all the complex organisms populating terrestrial and marine ecosystems exist and evolved as holobionts, and their genetic potential should be considered in the frame of their hologenomics, as well as their metabolism should be revised as co-metabolism. Understanding how symbiont communities contribute to the host phenotype it thus an emerging biological challenge, pawing the way to a next generation view of the biology of living organisms. We aim to pioneer this field, exploring the functionalities of the symbiont microbial communities in the holobiont context. Our research involve omics (mainly genomics and metabolomics) and system biology applied in the field of microbial ecology and host biology.

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