DATE AND PLACE OF BIRTH 19-05-57, Napoli (NA)
SEX AND NATIONALITY Female, Italian
BUSINESS TELEPHONE +39 051 798776
BUSINESS EMAIL luciana.giardino@unibo.it
BUSINESS ADDRESS DIMEVET, Università di Bologna, Via Tolara di Sopra 50-41/E, 40064 Ozzano Emilia (Bologna) Italy
PRESENT POSITION:
− Associate Professor of Embryology, Regenerative Medicine and Neurobiology at University of Bologna
- President of IRET Foundation-ONLUS
- Founder of TransMed Research srl, test facility GLP-approved
WEB:
https://www.unibo.it/sitoweb/luciana.giardino/en
http://www.iret-foundation.org/en/
http://www.transmed-research.com/
EDUCATION:
1982 University of Napoli Medical degree
1985 University of Modena Endocrinology Specialist Training
UNIVERSITIES ATTENDED AND POSITION OBTAINED:
1988-1992 Dpt of Pain Pathophysiology and Therapy, University of Milano, Assistant (funzionario tecnico VIII livello)
1992-1995 Dpt of Otolaryngology II, University of Milano, Assistant (funzionario tecnico VIII livello)
1995-1999 Dpt of Otolaryngology II, University of Milano, Assistant (Coordinatore tecnico IX livello)
1999-2001 DIMEVET, University of Bologna, Assistant (Coordinatore tecnico IX livello)
2001-2014 University of Bologna, Assistant Professor of Veterinary Anatomy
2014 associate professor at University of Bologna
2012 full professor eligibility (ASN, 07/H1-VET01)
SIGNIFICANT INTRAMURAL COMMITEES:
Scientific Director, Translation Medicine Unit Research Faculty Committee, 2018-2021
Research Commission, Veterniary School, member
MAJOR RESEARCH/PROFESSIONAL INTERESTS:
Luciana Giardino has a broad background in neurobiology, with specific training and expertise in chemical neuroanatomy, neurological behavioral analysis, molecular biology, cell cultures including stem cells, in the frame of the translational medicine principles.
Main focus of research activity is the study of neurodegenerative diseases, using in vivo and in vitro models, according to the bench-to-bedside and bed-to-benchside approach of the translational medicine. The lab develops the entire pipeline of the preclinical testing of new drugs and investigates self-repair properties of different tissues and organs based on the resident stem cells, and develops advanced therapies, biomaterials, biomedical devices also according to GLP and ISO guidelines. The lab belongs to the high-technology network of Emilia Romagna, and is a Technopole of the Emilia Romagna Region.
Techniques available in the lab:
• Breeding of rat and mice (also including transgenic mice)
• Microsurgery (stereotaxic microsurgery for icv and brain acute and chronic infusion, also using osmotic minipmps; chemical and immunological lesions of transmitter-identified pathways; neuroflogosis models –EAE, LPS)
• Behavioral studies (Morris water maze, fear conditioning test, object recognition tests, motor learning and coordination by Rotarod, spontaneous locomotor activity, pain threshold after thermal and mechanical stimulation, paw edema evaluation, quantitative allodynia, force grasping), SMART-Pan Lab and AnyMaze Stoelting tracking analysis softwares
• Histochemical and immunocytochemical techniques (IF, ABC, PAP), colocalization, TSA
• Molecular biology: in situ hybridization, semiquantitative PCR, real-time PCR, Northern blot, genotyping
• Proteomic: Western blot, Luminex xMAP technology
• In vitro: primary cultures; cell lines; embryonic and adult stem cells; cell transfection
• Laser capture microdissection
• Image analysis and quantification: morphometry, densitometry and microdensitometry (AIS Imaging, Image ProPlus, Cell^P image analysis, IMARIS softwares), confocal laser scan microscopy also in time-laps mode
• Dynamic imaging by confocal laser scan microscopy, FRET
AWARD:
1997 Fondazione Steven Newburgh, nominated by Rita Levi-Montalcini
PATENTS AWARDED:
- Nicergoline and its metabolites in the treatment of neurogenerative disorders of the retina and optic nerve, D001069, 2002, co-inventor
- AlgoDelta, RMG, 2004, co-inventor
- CHF5074 in Down syndrome, 2014, co-inventor
- Electrospun fibers for the local release of an anti-inflammatory and a promyelinating drug, PCT/IT2018/000084, inventorEndFragment
COMPETITIVE RESEARCH GRANTS (mains):
- MIUR, PRIN, 2002-2004, co-investigator; 2008-10, co-investigator
- FISM, 2004-05; principal investigator
- FISM, 2010-12; principal investigator
- Regione Emilia Romagna, 2010-12, NeuroBioTech, partner
- Step-by-Step, POR-FESR Emilia Romagna, 2016-2018, participant
COMPETITIVE RESEARCH GRANTS (active):
- MAT2REP, POR-FESR Emilia Romagna, 2019-2021, partner
- Regione Emili-Romagna, Colture 3D di cellule staminali embrionali (di ratto) come replacement degli studi GLP di teratogenesi, 2019-2021, principal investigator
- Fondazione CARISBO, Bologna, Infiammazione cronica intestinale e demenza di Alzheimer: un caso di comorbilità?, 2020-2021, principal investigator
INDUSTRIAL RESEARCH (mains):
Sigma Tau, Chiesi, RGMD, Igea, Pfizer, Pharmacia-Upjoung, Pharmades,
INDUSTRIAL RESEARCH (actives):
Chiesi, Applied Research
SCIENTIFIC PUBLICATION RANK (Scopus):
144 documents
4009 citations
37 h-index
