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Letizia Polito

Associate Professor

Department of Medical and Surgical Sciences

Academic discipline: MED/04 Experimental Medicine and Pathophysiology

Publications

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Publications prior to 2004

1.        Pasqualucci L, Wasik M, Teicher BA, Flenghi L, Bolognesi A, Stirpe F, Polito L, Falini B, Kadin ME. Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr 15;85(8):2139-46.

2.        Battelli MG, Buonamici L, Polito L, Bolognesi A, Stirpe F. Hepatoxicity of ricin, saporin or a saporin immunotoxin: xanthine oxidase activity in rat liver and blood serum. Virchows Arch. 1996 Feb;427(5):529-35.

3.        Battelli MG, Polito L, Bolognesi A, Lafleur L, Fradet Y, Stirpe F. Toxicity of ribosome-inactivating proteins-containing immunotoxins to a human bladder carcinoma cell line. Int J Cancer. 1996 Feb 8;65(4):485-90.

4.        Terenzi A, Bolognesi A, Pasqualucci L, Flenghi L, Pileri S, Stein H, Kadin M, Bigerna B, Polito L, Tazzari PL, Martelli MF, Stirpe F, Falini B. Anti-CD30 (BER=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful antitumour activity against CD30+ tumour cells in vitro and in SCID mice. Br J Haematol. 1996 Mar;92(4):872-9.

5.        Stirpe F, Barbieri L, Gorini P, Valbonesi P, Bolognesi A, Polito L. Activities associated with the presence of ribosome-inactivating proteins increase in senescent and stressed leaves.FEBS Lett. 1996 Mar 18;382(3):309-12.

6.        Vooijs WC, Post J, Wijdenes J, Schuurman HJ, Bolognesi A, Polito L, Stirpe F, Bast EJ, de Gast GC. Efficacy and toxicity of plasma-cell-reactive monoclonal antibodies B-B2 and B-B4 and their immunotoxins. Cancer Immunol Immunother. 1996 Jul;42(6):319-28.

7.        Bolognesi A, Tazzari PL, Olivieri F, Polito L, Falini B, Stirpe F. Induction of apoptosis by ribosome-inactivating proteins and related immunotoxins. Int J Cancer. 1996 Nov 4;68(3):349-55.

8.        Di Massimo AM, Di Loreto M, Pacilli A, Raucci G, D'Alatri L, Mele A, Bolognesi A, Polito L, Stirpe F, De Santis R. Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata. Br J Cancer. 1997;75(6):822-8.

9.        Battelli MG, Barbieri L, Bolognesi A, Buonamici L, Valbonesi P, Polito L, Van Damme EJ, Peumans WJ, Stirpe F. Ribosome-inactivating lectins with polynucleotide:adenosine glycosidase activity. FEBS Lett. 1997 May 26;408(3):355-9.

10.     Vooijs WC, Otten HG, van Vliet M, van Dijk AJ, de Weger RA, de Boer M, Bohlen H, Bolognesi A, Polito L, de Gast GC. B7-1 (CD80) as target for immunotoxin therapy for Hodgkin's disease. Br J Cancer. 1997;76(9):1163-9.

11.     Bolognesi A, Polito L, Olivieri F, Valbonesi P, Barbieri L, Battelli MG, Carusi MV, Benvenuto E, Del Vecchio Blanco F, Di Maro A, Parente A, Di Loreto M, Stirpe F. New ribosome-inactivating proteins with polynucleotide:adenosine glycosidase and antiviral activities from Basella rubra L. and bougainvillea spectabilis Willd. Planta. 1997 Dec;203(4):422-9.

12.     Battelli MG, Bolognesi A, Olivieri F, Polito L, Stirpe F. Different sensitivity of CD30+ cell lines to Ber-H2/saporin-S6 immunotoxin. J Drug Target. 1998;5(3):181-91.

13.     Bolognesi A, Tazzari PL, Olivieri F, Polito L, Lemoli R, Terenzi A, Pasqualucci L, Falini B, Stirpe F. Evaluation of immunotoxins containing single-chain ribosome-inactivating proteins and an anti-CD22 monoclonal antibody (OM124): in vitro and in vivo studies. Br J Haematol. 1998 Apr;101(1):179-88.

14.     Valbonesi P, Barbieri L, Bolognesi A, Bonora E, Polito L, Stirpe F. Preparation of highly purified momordin II without ribonuclease activity. Life Sci. 1999;65(14):1485-91.

15.     Bolognesi A, Polito L, Tazzari PL, Lemoli RM, Lubelli C, Fogli M, Boon L, de Boer M, Stirpe F. In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins. Br J Haematol. 2000 Aug;110(2):351-61.

16.     Barbieri L, Bolognesi A, Valbonesi P, Polito L, Olivieri F, Stirpe F. Polynucleotide: adenosine glycosidase activity of immunotoxins containing ribosome-inactivating proteins. J Drug Target. 2000;8(5):281-8.

17.     Di Maro A, Ferranti P, Mastronicola M, Polito L, Bolognesi A, Stirpe F, Malorni A, Parente A. Reliable sequence determination of ribosome- inactivating proteins by combining electrospray mass spectrometry and Edman degradation. J Mass Spectrom. 2001 Jan;36(1):38-46.

18.     Pistillo MP, Tazzari PL, Stirpe F, Bolognesi A, Polito L, Capanni P, Pioli C, Gatta L, Ubaldi V, Doria G, Conte R, Ferrara GB. Anti-CTLA-4 human scFv antibodies prevent T-cell activation in transplantation. Transplant Proc. 2001 Feb-Mar;33(1-2):285-7.

19.     Tazzari PL, Polito L, Bolognesi A, Pistillo MP, Capanni P, Palmisano GL, Lemoli RM, Curti A, Biancone L, Camussi G, Conte R, Ferrara GB, Stirpe F. Immunotoxins containing recombinant anti-CTLA-4 single-chain fragment variable antibodies and saporin: in vitro results and in vivo effects in an acute rejection model. J Immunol. 2001 Oct 15;167(8):4222-9.

20.     Campos EC, Schiavi C, Bolognesi A, Bellusci C, Lubelli C, Duca A, Polito L, Poulas K, Tzartos SJ, Stirpe F. Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73. Curr Eye Res. 2002 Jan;24(1):58-65.

21.     Gosselaar PH, van-Dijk AJ, de-Gast GC, Polito L, Bolognesi A, Vooijs WC, Verheul AF, Krouwer HG, Marx JJ. Transferrin toxin but not transferrin receptor immunotoxin is influenced by free transferrin and iron saturation. Eur J Clin Invest. 2002 Mar;32 Suppl 1:61-9.

22.     Bolognesi A, Polito L, Lubelli C, Barbieri L, Parente A, Stirpe F. Ribosome-inactivating and adenine polynucleotide glycosylase activities in Mirabilis jalapa L. tissues. J Biol Chem. 2002 Apr 19;277(16):13709-16.

23.     Ricci C, Polito L, Nanni P, Landuzzi L, Astolfi A, Nicoletti G, Rossi I, De Giovanni C, Bolognesi A, Lollini PL. HER/erbB receptors as therapeutic targets of immunotoxins in human rhabdomyosarcoma cells. J Immunother. 2002 Jul-Aug;25(4):314-23.

24.     Pistillo MP, Tazzari PL, Palmisano GL, Pierri I, Bolognesi A, Ferlito F, Capanni P, Polito L, Ratta M, Pileri S, Piccioli M, Basso G, Rissotto L, Conte R, Gobbi M, Stirpe F, Ferrara GB. CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells. Blood. 2003 Jan 1;101(1):202-9.

25.     Fermani S, Falini G, Ripamonti A, Bolognesi A, Polito L, Stirpe F. Crystallization and preliminary X-ray diffraction analysis of two ribosome-inactivating proteins: lychnin and dianthin 30. Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1227-9.


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