Microbiota and NGS Technologies – Investigation of the human microbiota using Next Generation Sequencing approaches (16S rRNA gene sequencing and shotgun metagenomics) for the taxonomic and functional characterization of complex microbial ecosystems, with particular focus on onco-hematological and transplant settings.
Advanced Bioinformatics and Biostatistics – Application of multivariate models, longitudinal analyses, integration of clinical covariates, and confounder-adjustment strategies for the interpretation of high-dimensional, complex datasets.
Multi-Omics Approach – Integration of metagenomic, metabolomic, and clinical data within a systems biology framework to elucidate interactions between the microbiota, host metabolism, immune response, and therapeutic outcomes, contributing to the development of precision medicine strategies.
Clinical Research and Trials – Design and participation in clinical trials aimed both at microbiota modulation and, more broadly, at evaluating the clinical effects of novel therapies and pharmaceutical formulations. This includes the assessment of efficacy, safety, and ADMET profiles, as well as patient stratification based on biological and clinical parameters. Activities include targeted collaborations on specific projects, adopting an integrated preclinical, translational, and clinical research approach.
Fecal Microbiota Transplantation (FMT) and Co-Transplantation – Investigation of the role and impact of FMT across different pathological contexts, with particular focus on co-transplantation strategies in patients undergoing hematopoietic stem cell transplantation (HSCT), as well as in liver and pancreatic transplantation, evaluating effects on complications, immune response, and clinical recovery.
Climate Change and Health – TRIGGER Project – Within the European project TRIGGER (SoluTions foR mItiGatinG climate-induced hEalth thReats), I contribute to investigating the interaction between climate change, environmental exposures (climate and pollution), and the human microbiome under the exposome framework. My role focuses on analyzing microbiome dynamics in relation to meteorological and environmental variables and assessing their impact in modulating the risk of acute cardiorespiratory events. This work is embedded in a multidimensional clinical study conducted by an international consortium and contributes to the development of predictive tools for global health protection.
The overarching goal of my research is to integrate biological, environmental, and clinical data to systematically understand the determinants of health and to develop innovative strategies for prevention and therapeutic intervention.
