Foto del docente

Flavio Flamigni

Associate Professor

Department of Biomedical and Neuromotor Sciences

Academic discipline: BIO/10 Biochemistry

Research

Keywords: Polyamines Chondrocytes Signal Transduction microRNA Cardiac cells nutraceuticals

MAIN RESEARCH FIELDS:

- biochemical aspects of autophagy, growth, differentiation, apoptosis and senescence of human and mammalian cells, also in relation to pathological conditions, such as cardiovascular and arthritic diseases;

- metabolism and function of aliphatic polyamines, with particular attention to ornithine decarboxylase;

- functions of extra-cellular messengers and signal transduction pathways, such as those involving IKK/NF-kB, MAPK, PI3K/Akt, AMPK and sirtuins;

- expression of specific microRNAs and their role in the regulation of key proteins and cellular processes;

- effects of nutraceuticals and nutritional factors.

Biochemical and molecular techniques are being used to investigate these metabolic and signaling networks. Pharmalogical and genetic approaches are employed to inhibit key proteins. Main experimental models:

1) primary cultures of chondrocytes and chondrocyte-derived cell lines, treated with various stimuli, such as pro-inflammatory and anti-inflammatory cytokines; 

2) primary cultures of cardiomyocytes and cardiac cell lines (H9c2), submitted to stress conditions and neuro-hormonal factors;

3) mesenchymal stem cells from various sources stimulated to differentiation towards different phenotypes for regenerative medicine.

 

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