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Federica del Monte

Associate Professor

Department of Medical and Surgical Sciences

Academic discipline: BIO/11 Molecular Biology

Publications

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Publications prior to 2004

Peer reviewed publications in print or other media [http://cv.hms.harvard.edu/index.php?page=peer_review] ** formally supervised trainee

H-Index 51; i10 index 89 https://scholar.google.com/citations?

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  1. Puddu PE, del Monte F, Reale A. Time risk and sudden death: a new perspective for research? Cardiologia. 1989 Mar;34(3):191-4. Italian. No abstract available. PMID: 2743361
  2. Greco C, Di Piero V, Cavalletti C, Argentino C, D'Agostino R, del Monte F, Scopinaro F. Myocardial ischemia during stroke: scintigraphic demonstration. Cardiologia 1989; 34 (5): 455-457. PMID: 2758448
  3. Jones SM, Hunt NA, del Monte F, Harding SE. Contraction of cardiac myocytes from noradrenaline-treated rats in response to isoprenaline, forskolin and dibutyryl cAMP. Eur J Pharmacol 1990; 191 (2): 129-140. PMID: 1964904
  4. Harding SE, Jones SM, O'Gara P, del Monte F, Vescovo G, Poole-Wilson PA. Isolated ventricular myocytes from failing ad non-failing human heart; the relation of age and clinical status of patients to isoproterenol response. J Mol Cell Cardiol 1992; 24 (5): 549-564. PMID: 1321914
  5. Harding SE, Jones SM, Vescovo G, del Monte F, Poole-Wilson PA. Reduced contractile response to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle. Eur J Pharmacol 1992; 223 (1): 39-48. PMID: 1335876
  6. Monti F, Dawodu AA, Giglio V, Lanti M, del Monte F, Sugimoto S, Terracciano C, Schiariti M, Puddu PE, Campa PP. Effetti inotropi e batmotropi della beta stimolazione: studio di confronto tra dobutamina e dopamina nel muscolo papillare di cavia in contrazione isometrica. Cardiologia 1992; 37 (19): 635-639. PMID: 1292869
  7. del Monte F, Mynett JR, Sugden PH, Poole-Wilson PA, Harding SE. Subcellular mechanism of the species difference in the contractile response of ventricular myocytes to endothelin-1. Cardioscience 1993; 4 (3): 185-191. PMID: 8400027
  8. del Monte F, Kaumann AJ, Poole-Wilson PA, Wynne DG, Harding SE. Coexistence of functioning b1- and b2-adrenoceptors in single myocytes from failing human ventricle. Circulation 1993; 88 (3): 854-863. PMID: 8102599 Cited by 115 related articles
  9. Naqvi RU, del Monte F, O'Gara P, Harding SE, MacLeod KT. Characteristics of myocytes isolated from the heart of renovascular hypertensive guinea pigs. Am J Physiol 1994; 266 (5 Pt 2): H1886-H1895. PMID: 8203588
  10. Ferrara N, O'Gara P, Wynne DG, Brown LA, del Monte F, Poole-Wilson PA, Harding SE. Decreased contractile responses to isoproterenol in isolated cardiac myocytes from aging guinea pigs. J Mol Cell Cardiol 1995; 27(5): 1141-1150. PMID: 7473772
  11. Sanders L, Lynham JA, Bond B, del Monte F, Harding SE, Kaumann AJ. Sensitisation of human atrial 5-HT4receptors by chronic b-blocker treatment. Circulation 1995; 92 (9): 2526-2539. PMID: 7586354
  12. del Monte F, O'Gara P, Poole-Wilson PA, Yacoub M, Harding SE. Cell geometry and contractile abnormalities of myocytes from failing human ventricle. Cardiovasc Res 1995; 30 (2): 281-290. PMID: 7585816
  13. Sugimoto S, Puddu PE, Monti F, Dawodu AA, del Monte F, Schiariti M, Campa PP, Marino B. Activation of ATP-dependent K+channels enhances myocardial protection due to cold high potassium cardioplegia: a force-frequency relationship study. J Mol Cell Cardiol 1995; 27 (9): 1867-1881. PMID: 8523448
  14. Lefroy DC, Crake T, del Monte F, Vescovo G, Dalla Libera LD, Harding SE, Poole-Wilson PA. Angiotensin II and contraction of isolated myocytes from human, guinea-pig and infarcted rat hearts. Am J Physiol 1996; 270 (Pt 2): H2060-H2069. PMID: 8764257
  15. Harding SE, Brown LA, del Monte F, Davies CH, O'Gara P, Vescovo G, Wynne DG, Poole-Wilson PA. Acceleration of contraction by b-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts. Basic Res Cardiol 1996; 91 Suppl 2: 53-56. PMID: 8957545
  16. Wynne DG, del Monte F, Harding SE. Cyclic AMP levels in ventricular myocytes from noradrenaline-treated guinea pigs. Eur J Pharmacol 1996; 310: 235-242. PMID: 8884222
  17. Harding S.E., Brown L.A., del Monte F, Davies C.H., O'Gara P., Vescovo G., Wynne D.G., Poole-Wilson P.A. Acceleration of contraction by b-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts. Basic Res Cardiol 1996; 91 Suppl 2: 53-56.
  18. del Monte F, Harding SE, Schmidt U, Matsui T, Kang ZB, Dec GW, Gwathmey JK, Rosenzweig A, Hajjar RJ. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 1999; 100: 2308-2311. Invited journal cover. Cited by 369 related articles
  19. Matsui T, del Monte F, Li L, Fukui Y, Franke TF, Hajjar RJ, Rosenzweig A. Adenoviral gene transfer of activated PI3-kinase and Akt inhibits apoptosis of hypoxic cardiocytes. Circulation 1999; 100: 2373-2379.
  20. Choukroun G, Hajjar R, Fry S, del Monte F, Haq S, Guerrero JL, Picard M, Rosenzweig A, Force T. Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinase/c-Jun NH2-terminal kinases. J Clin Invest 1999; 104 (4): 391-398. PMID: 10449431
  21. Picard S, Criniti A, Iwashiro K, Rouet R, Monti F, Tonelli E, Ruvolo G, Ducourt P, del Monte F, Papalia U, Puddu PE. Protection of human myocardium in vitro by K(ATP) activation with low concentrations of bimakalim. J Cardiovasc Pharmacol 1999; 34 (1): 162-172. PMID: 10413083
  22. Schmidt U, del Monte F, Miyamoto MI, Matsui T, Gwathmey JK, Rosenzweig A, Hajjar RJ. Restoration of diastolic function in senescent rat hearts by adenoviral gene transfer of sarcoplasmic reticulum Ca2+ ATPase. Circulation 2000; 101 (7): 790-796. PMID: 10683354
  23. Myamoto MI, del Monte F, Schmidt U, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ. Adenoviral gene transfer of SERCA2a improves left ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci 2000; 97 (2): 793-798. PMID: 10639159
  24. Haq S, Choukroun G, Lim HW, Tymitz KM, del Monte F, Gwathmey JK, Grazette L, Michael A, Hajjar RJ, Force TL, Molkentin J. Differential activation of signal transduction pathways in human hearts during hypertrophy and failure. Circulation 2001; 103: 670 - 677. PMID: 11156878
  25. DeWindt LJD, Lim HW, Bueno OF, Tymititz KM, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proc Natl Acad Sci 2001; 98: 3322-3327. PMID: 11248077
  26. Davia K, Bernobich E, Ranu HK, del Monte F, Terracciano CM, MacLeod KT, Adamson DL, Chaudhri B, Hajjar RJ, Harding SE. SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes. J Mol Cell Cardiol 2001; 33(5): 1005-1015. PMID: 11343422
  27. Matsui T, Tao J, Lee K-H, Li L, del Monte F, Picard M, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia. Circulation 2001; 104: 330-335. PMID: 11457753
  28. del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski D, Hajjar RJ. Improvement in survival and cardiac metabolism following gene transfer of SERCA2a in an animal model of heart failure. Circulation 2001; 104:1424-1429. PMID: 11560860 Cited by 328 related articles
  29. 29. del Monte F, Harding S, Dec GW, Gwathmey JK, Hajjar RJ. Targeting phospholamban in human heart failure by gene transfer. Circulation 2002; 105: 904-907. PMID: 11864915 Cited by 238 related articles
  30. del Monte F, Butler K, Boecker W, Gwathmey JK, Lewandowski D, Hajjar RJ. Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiol Genom 2002; 9: 49-56. PMID: 11948290
  31. Carr A, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Gerst M, Allen PB, Greengard P, Yatani, A, Hoit B, Grupp I, Hajjar RJ, dePaoli-Roach A, Kranias E. Type 1 phosphatase A negative regulator of cardiac function. Mol Cell Biol 2002 22: 4124-4135. PMID: 12024026
  32. Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe P, Hajjar RJ, Linke M. Titin isoform switch in ischemic human heart disease. Circulation Sept 2002; 106: 1333-1341. PMID: 12221049
  33. Chaudhri B, del Monte F, Hajjar RJ, Harding SE. Interaction between increased SERCA2a activity and b-adrenoceptor stimulation in adult rabbit myocytes. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6): H2450-7. PMID: 12388307
  34. del Monte F*, Nakayama A*, Hajjar RJ, Frangioni JV. Functional imaging for surgery and targeted gene therapy. Mol Imaging; 2002: 1: 365-377. PMID: 12940233
  35. Chaudhri B, del Monte F, Hajjar JR, Harding SE. Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes. Mol Cell Biochem; 2003; 251:103-109. PMID: 14575311
  36. del Monte F, Lebeche D, Guerrero JL, Tsuji T**, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. PNAS 2004; 101(15): 5622-5627. PMID: 15044708. Cited by 154 related articles
  37. del Monte F, Dalal R**, Tabchy A**, Couget J, Bloch KD, Peterson R, Hajjar RJ. Transcriptional changes following restoration of SERCA2a levels in failing rat hearts FASEB J. 2004 Sep;18(12):1474-6. PMID: 15247151
  38. Boecker W, Bernecker OY, Wu JC, Zhu X, Sawa T, Grazette L, Rosenzweig A, del Monte F, Schmidt U, Hajjar RJ. Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Mol Imaging. 2004 Apr; 3(2): 69-75. PMID: 15296671
  39. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, del Monte F, Hajjar RJ, Linke. WA.Passive Stiffness Changes Due To Upregulation of Compliant Titin Isoforms in Human Dilated Cardiomyopathy Hearts. Circ Res. 2004 Oct 1; 95(7): 708-16. PMID: 15345656
  40. Lebeche D, Kaprielian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, Hajjar RJ. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 2004 Nov 30; 110(22): 3435-43. PMID:15557376
  41. Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bondi I, Weiser D, Hahn H, Carr AN, Syed F, MAvila N, Jha L, Qiuan J, Marreez Y, Chen G, McGraw DW, Heist HK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res 2005; 96 (7): 756-66. PMID:16007268
  42. Hayase M, del Monte F, MacNeill B, Mcgregor J, Yoneyama R, Kawase Y, Hoshino K, Tsuji T, Hajjar R Catheter-Based Antegrade Intracoronary Viral Gene Delivery with Coronary Venous Blockade Am J Physiol Heart Circ Physiol 2005; 288 (6): H2995-3000. PMID:15897329
  43. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest 2005, 115 (8): 2128-2138. PMID:16007268
  44. Lipskaia L, del Monte F, Copiod T, Yacoubi S, Hadri L**, Hours M, Hajjar RJ, Lompre’ A-M. Sarco/endoplasmic reticulum Ca2+-ATpase gene transfer reduces VSMC proliferation and neointima formation in the rat. Circularion Research 2005, 97 (5): 488-95. PMID:16081870
  45. Dally S, Bredoux R, Corvazier E, Andersen JP, Clausen JD, Dode L, Fanchaouy M, Gelebart P, Monceau V, , Gwathmey JK, Hajjar R, Chaabane C, Bobe R, Raies A, Enouf J. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16402920&query_hl=1&itool=pubmed_docsum] Ca 2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca 2+ATPase 2 isoform (SERCA2c). Biochem J. 2006 Apr 15; 395(2): 249-58. PMID:16402920
  46. Sakata S**, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P**, Konishi N, Takaki M, , Hajjar RJ. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16503203&query_hl=1&itool=pubmed_docsum] Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther. 2006 May; 13(5): 987-96. PMID:16503203
  47. Gregory KN, Ginsburg KS, Bodi I, Hahn H, Marreez YM, Song Q, Padmanabhan PA**, Mitton BA, Waggoner JR, , Park WJ, Dorn GW 2nd, Bers DM, Kranias EG. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16600288&query_hl=1&itool=pubmed_docsum] Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. J Mol Cell Cardiol. 2006 May; 40(5): 653-65. PMID: 16600288
  48. Prunier F, Pfister O, Hadri L, Liang L, , Liao R, Hajjar RJ. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16997893&query_hl=1&itool=pubmed_docsum] Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1): H522-9. PMID: 16997893
  49. Sakata S**, Lebeche D, Sakata Y, Sakata N, Chemaly E, Liang L, Nakajima-Takenaka C, Tsuji T**, Konishi N, , Hajjar RJ, Takaki M. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17012346&query_hl=1&itool=pubmed_docsum] Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type II diabetic rat model. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2): H1204-7. PMID: 17012346
  50. Sakata S**, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Tsuji T**, Takewa Y, , Peluso R, Zsebo K, Jeong D, Park WJ, Kawase Y, Hajjar RJ. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17300800&query_hl=21&itool=pubmed_docsum] Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J Mol Cell Cardiol. 2007 Apr; 42(4): 852-61. PMID: 17300800
  51. Palomeque J, Chemaly ER, Colosi P, Wellman JA, Zhou S, , Hajjar RJ. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17251988&query_hl=21&itool=pubmed_docsum] Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo. Gene Ther. 2007 Jul; 14(13):989-97. Erratum in: Gene Ther. 2007 Jul; 14(13): 1055. PMID: 17251988
  52. Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. [http://www.ncbi.nlm.nih.gov/pubmed/17526652] Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1581-9. PMID: 17526652
  53. Kühn B**, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. [http://www.ncbi.nlm.nih.gov/pubmed/17632525] Nat Med. 2007 Aug;13(8):962-9. PMID:17928048
  54. Beeri R, Yosefy C, Guerrero JL, Nesta F, Abedat S, Chaput M, del Monte F, Handschumacher MD, Stroud R, Sullivan S, Pugatsch T, Gilon D, Vlahakes GJ, Spinale FG, Hajjar RJ, Levine RA. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J Am Coll Cardiol. 2008 Jan 29; 51(4): 476-86. doi: 10.1016/j.jacc.2007.07.093. PMID: 18222360
  55. Haddad GE, Saunders LJ, Crosby SD, Carles M, del Monte F, King K, Bristow MR, Spinale FG, Macgillivray TE, Semigran MJ, Dec GW, Williams SA, Hajjar RJ, Gwathmey JK. Human Cardiac Specific cDNA Array for Idiopathic Dilated Cardiomyopathy: Gender Related Differences. Physiol Genomics. 2008 Apr 22; 33(2): 267-77. doi: 10.1152/physiolgenomics.00265.2007. PMID: 18303083
  56. Neilan TG, Ton-Nu TT, Kawase Y, Yoneyama R, Hoshino K, del Monte F, Hajjar RJ, Picard MH, Levine RA, Hung J. The Progressive Nature of Chronic Mitral Regurgitation and the Role of Tissue Doppler derived Indices. Am J Physiol Heart Circ Physiol. 2008 May; 294(5): H2106-11. doi: 10.1152/ajpheart.01128.2007. PMID: 18326805
  57. Haddad GE, Saunders L, Carles M, Crosby SD, del Monte F, Macgillivray TE, Semigran MJ, Dec GW, Hajjar RJ, Doye AA, Glass R, El M, Gwathmey JK. Fingerprint profile of alcohol-associated heart failure in human hearts. Alcohol Clin Exp Res. 2008 May; 32(5): 814-21.P. doi: 10.1111/j.1530-0277.2008.00628. PMID: 18336640
  58. Prunier F, Kawase Y, Gianni D**, Scapin C**, Danik SB, Ellinor PT, Hajjar RJ, del Monte F: Prevention of ventricular arrhythmias with SERCA2a overexpression in a porcine model of ischemia reperfusion. Circulation 2008; Aug 5; 118(6): 614-24. doi: 10.1161/CIRCULATIONAHA.108.770883. PMID: 18645052. Cited by 66 related articles
  59. Dally S, Monceau V, Corvazier E, Bredoux R, Raies A, Bobe R, del Monte F, Enouf J. Compartmentalized expression of three novel sarco/endoplasmic reticulum Ca(2+)ATPase 3 isoforms including the switch to ER stress, SERCA3f, in non-failing and failing human heart. [http://www.ncbi.nlm.nih.gov/pubmed/18947868?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum] Cell Calcium. 2009 Feb; 45(2): 144-54. doi: 10.1016/j.ceca.2008.08.002. PMID: 18947868
  60. Tsuji T**, del Monte F, Yoshikawa Y, Abe T, Shimizu J, Nakajima-Takenaka C, Taniguchi S, Hajjar RJ, Takaki M. Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2): H310-7. doi: 10.1152/ajpheart.00975.2008. PMID: 19074672
  61. Gianni D**, Li A, Tesco G, McKay K M, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, del Monte F. Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy. Circulation 2010 Mar 1. 121(10): 1216-26. doi: 10.1161/CIRCULATIONAHA.109.879510. PMID: 20194882. Cited by 20 related articles
  62. Shi J, Guan J, Jiang B, Brenner DA, del Monte F, Ward JE, Connors LH, Sawyer DB, Semigran MJ, Macgillivray TE, Seldin DC, Falk R, Liao R. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. [http://www.ncbi.nlm.nih.gov/pubmed/20150510] Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9): 4188-93. doi: 10.1073/pnas.0912263107. PMID: 20150510
  63. Karamanlidis G, Nascimben L, Couper G, Prem Shekar, del Monte F, Tian R. Decreased mtDNA copy number in human heart failure despite increased PGC-1α protein levels. Circ Res. 2010 May 14; 106(9): 1541-8. doi: 10.1161/CIRCRESAHA.109.212753. PMID: 20339121
  64. Lubitz SA, Sinner MF, Lunetta KL, Makino S, Pfeufer A, Rahman R, Veltman CE, Barnard J, Bis JC, Danik SP, Sonni A, Shea MA, del Monte F, Perz S, Müller M, Peters A, Greenberg SM, Furie KL, van Noord C, Boerwinkle E, Stricker BH, Witteman J, Smith JD, Chung MK, Heckbert SR, Benjamin EJ, Rosand J, Arking DE, Alonso A, Kääb S, Ellinor PT. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. [http://www.ncbi.nlm.nih.gov/pubmed/20733104] Circulation. 2010 Sep 7; 122(10): 976-84. doi:10.1161/CIRCULATIONAHA.109.886440. PMID: 20733104
  65. Peña JR, Szkudlarek AC, Warren C, Heinrich LS, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Neonatal Gene Transfer of Serca2a Delays Onset of Hypertrophic Remodeling and Improves Function in Familial Hypertrophic Cardiomyopathy. J Mol Cell Cardiol. 2010 Dec; 49(6): 993-1002. doi: 10.1016/j.yjmcc.2010.09.010. PMID: 20854827
  66. L Gorza; B Ravara; C Scapin**; M Vitadello; FM Zigrino; G Gerosa; JK Gwathmey; F del Monte. Myofibrillar protein carbonylation and loss of troponin-T and desmin integrity: parallel investigations in ischemic human and rat hearts Cardiovascular Research. 2010; 87(20100701): S45–S88.
  67. Cilenti L, Balakrishnan MP, Wang XL, Ambivero C, Sterlicchi M, del Monte F, Ma XL, Zervos AS Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. [http://www.ncbi.nlm.nih.gov/pubmed/21195082] J Mol Cell Cardiol. 2011 Apr; 50(4): 652-61 doi: 10.1016/j.yjmcc.2010.12.015. PMID: 21195082
  68. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N**, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. [http://www.ncbi.nlm.nih.gov/pubmed/22596155] Nature. 2012 May 9;485(7398):333-8. doi: 10.1038/nature11040. PMID: 22596155
  69. Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. [http://www.ncbi.nlm.nih.gov/pubmed/23019294] Circulation. 2012 Oct 30; 126(18): 2208-19. doi: 10.3791/50289. PMID: 23088184
  70. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. [http://www.ncbi.nlm.nih.gov/pubmed/23867623] J Clin Invest. 2013 Aug 1;123(8):3378-82. doi: 10.1172/JCI67383. PMID: 23867623
  71. Guan J, Mishra S, Shi J, Plovie E, Qiu Y, Cao X, Gianni D**, Jiang B**, del Monte F, Connors LH, Seldin DC, Lavatelli F, Rognoni P, Palladini G, Merlini G, Falk RH, Semigran MJ, Dec GW Jr, Macrae CA, Liao R. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. [http://www.ncbi.nlm.nih.gov/pubmed/23982491] Basic Res Cardiol. 2013 Sep;108(5):378. doi: 10.1007/s00395-013-0378-5. PMID: 23982491
  72. Graham EL**, Balla C**, Franchino H, Melman Y, Das S*, del Monte F*. *Co-last and corresponding authors. Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes. J Vis Exp. 2013 Sep 24;(79). doi: 10.3791/50289. PMID: 24084584
  73. Lin H, Dolmatova EV, Morley MP, Lunetta KL, McManus DD, Magnani JW, Margulies KB, Hakonarson H,del Monte F, Benjamin EJ, Cappola TP, Ellinor PT. Gene expression and genetic variation in human atria. [https://www.ncbi.nlm.nih.gov/pubmed/24177373] Heart Rhythm. 2014 Feb;11(2):266-71. doi: 10.1016/j.hrthm.2013.10.051.
  74. Subramanian K**, Gianni D**, Balla C**, Egidy Assenza G, Joshi M, Semigran MJ, Macgillivray TE, Van Eyk JE, Agnetti G, Paolocci N, Bamburg JR, Agrawal PB, del Monte F. Cofilin-2 Phosphorylation and Sequestration In Myocardial Aggregates: Novel Pathogenetic Mechanisms For Idiopathic Dilated Cardiomyopathy. JACC 2015; 65 (12): 1199-214. This article was accompanied by an editorial and the editor’s commentary.
  75. Bernini F**, Malferrari D**, Pignataro M**, Bortolotti CA**, Di Rocco G, Lancellotti L, Brigatti MF, Borsari, M, Castellini E, del Monte F. Pre-amyloid oligomers budding: a metastatic mechanism of proteotoxicity. Scientific Reports 2016; 6: 35865
  76. Troncone L**, Luciani M**, Coggins M, Ho CY, Smith N, Crain B, Frosh MP, del Monte F. Aβ Amyloid Pathology Affects the Hearts of PatientsWithAlzheimer's Disease: Mindthe Heart. JACC 2017 This article was accompanied by an editorial, the editor’s commentary and a letter. It was included in the best of JACC 2016; 68 (22): 2395-2407). This work was received significant attention by the press and scored at the 99th percentile compared to the output of the same age by Altimetric (https://jacc.altmetric.com/details/14137202/news ). (http://www.onlinejacc.org/sites/default/files/Bestof2016/JACC_Booklet_Bestof2016.pdf).
  77. Luciani M**, del Monte F. Insights from Second-line treatments for idiopathic dilated cardiomyopathy. Journal Cardiovascular Development and Disease. Special Issue on Genetics and Treatment of Dilated Cardiomyopathy. 2017; 4 (12)
  78. Luciani M**, Troncone L**, del Monte F. From current to future circulating biomarkers for cardiac amyloidosis. Acta Pharmacologica Sinica 2018. Jul;39(7):1133-1141. doi: 10.1038/aps.2018.38 PMID:29770800. This article was accompanied by an editorial.
  79. Luciani M, del Monte F. The More We Learn, The Less We Know: A novel cardiac mechanism of brain damage. J Mol Cell Cardiol. 2019 Jan 28. pii: S0022-2828(19)30017-3. This article was accompanied by the Journal cover
  80. Tublin JM, del Monte F, Combs CK, Wold LE. Getting to the heart of alzheimer’s disease pathology. Circ Res 2019 Jan 4;124(1):142-149
  81. Toomer K, Yu. M, Fulmer D, Guo L, Moore K, Moore R, Drayton K, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Da Silveira W, Wang B, Leyne M, Durst R, Markwald R, Le Scouranec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska E, Schott JJ, Levine RA, Milan D, Bouatia-Naji N, Slaugenhaupt S, Norris RA Mitral Valve Prolapse: A congenital defect of primary cilia. Science Translational Medicine 2019; 11 (493) pii: eaax0290. doi: 10.1126/scitranslmed.aax0290. PMID: 31118289
  82. Suryadevara V, Kluppel, M, del Monte F, Willis M. The unravelling: cardiac and musculoskeletal defects and their role in common Alzheimer Disease Morbidity and Mortality. Am J Pathol 2020, 190(8):1609-1621.doi: 10.1016/j.ajpath.2020.04.013.
  83. Daniele G, DiLucia S, Maci PG, del Monte F. Heart and Brain: Complex Relationships for Left Ventricular Dysfunction. Current Cardiology Reports 2020, 22(8): 72. 10.1007/s11886-020-01318-w [https://dx.doi.org/10.1007%2Fs11886-020-01318-w] . PMCID:PMC7309683. PMID:32577917 [https://www.ncbi.nlm.nih.gov/pubmed/32577917]
  84. Pignataro M, Di Rocco G, Lancellotti L, Bernini F, Subramanian K, Castellini E, Bortolotti CA, Malferrari D, Moro D, Valdrè G, Borsari M, del Monte F. Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation. Redox Biology 2020, 37 October 2020, 10169 https://doi.org/10.1016/j.redox.2020.101691
  85. Pignataro M, Di Rocco G, Lancellotti L, Bernini F, Subramanian K, Castellini E, Bortolotti CA, Malferrari D, Moro D, Valdrè G, Borsari M, del Monte F. Electrochemical Data on Redox Properties of human Cofilin-2 and its Mutant S3D. Data in Brief 2020, 33 106345.
  86. Narasimhan KKS, Devarajan A, Karan G, Sundaram S, Wang Q, van Groen T, del Monte F, Rajasekaran, NS. Reductive stress promotes protein aggregation and impairs neurogenesis. Redox Biology 2020, 101739 https://doi.org/10.1016/j.redox.2020.101739
  87. Evangelisti A**, *, Butler H*, del Monte F. The Heart of Alzheimer's: A Modern Mind Approach to Cardiovascular Disease. Frontiers in Physiology 2021

Book Chapters

  1. 95. Piccolo GP, Macchiarelli AG, Scibilia G, del Monte F. Protocolli relativi a particolari precauzioni da seguire nel trattamento del ricevente, nel periodo post-operatorio immediato. In: Marino B, Piccoli G, editors. Il Trapianto Cardiaco Ortotopico. Roma: Masson; 1990: 191-193.
  2. 96. Piccolo GP, Macchiarelli AG, Scibilia G, del Monte F. Protocolli di comportamento e di condotta del personale addetto alla cura del ricevente nel periodo post-operatorio immediato. In: Marino B, Piccoli G, editors. Il Trapianto Cardiaco Ortotopico. Roma: Masson; 1990: 195-198.
  3. 97. Jones SM, Hunt NA, del Monte F, Harding SE. Reduced contractile response to stimulation by isoprenaline, forskolin and dibutyryl cAMP in isolated myocytes from noradrenaline-treated rats. In: Anonymous, editors. Adrenoceptors: Structure, Mechanisms, Function. Advances in Pharmacological Science. The Pharmacology of Adrenoceptors. E Szabadi: Basel; 1991: 331-332.
  4. 98. Harding SE, Brown LA, del Monte F, O'Gara P, Wynne DG, Poole-Wilson PA. Parallel changes in the b-adrenoceptor/adenylyl cyclase system between the failing human heart and the noradrenaline-treated guinea-pig. In: Nagano M, Takeda N, Dhalla NS, editors. The Cardiomyopathic Heart. Raven Press; 1993: 361-374.
  5. 99. Davies CH, Brown LA, del Monte F, Poole-Wilson PA, Harding SE. Myocardial cell abnormalities in heart failure: experience from studies on single myocytes. In: Dhalla NS, editors. Heart Hypertrophy and Failure. Boston-Dordrecht-London: Kluwer Academic Publishers; 1994. Chapter 16.
  6. 100. del Monte F, Puddu P.E., Harding S.E. b-adrenoceptor desensitisation in human heart failure: focus on isolated myocytes. In: Puddu PE, Bing RJ, Campa PP, Poole-Wilson PA, editors. Congestive Heart Failure: From Basic Science to Therapeutics. Roma: Cardioricerca; 1997: 39-62.
  7. 101. del Monte F, Harding SE, Hajjar RJ. Manipulation of SERCA2a in the heart by gene transfer. In: Hasensfuss G, Marban E. Molecular Strategy to the Therapy of Heart Failure. Springer; 2000: 53-68.
  8. Gwathmey JK, del Monte F, Kaprielian R, Hajjar RJ. Abnormalities of calcium homeostasis and defective excitation-contraction coupling in cardiomyopathy. In: Willerson JT, editor. Pathogenic Basis of Myocardial Diseases. Kluwer Publishers; 2002. Chapter 8: 133-152
  9. del Monte F, Hajjar RJ. Efficient viral gene transfer to rodent hearts in vivo. In: Metzger J, editor. Methods in Molecular Biology: Cardiac Cell & Gene Transfer. Vol. 219. Totowa, NJ: Humana Press; 2002. Chapter 14.
  10. Harding SE, del Monte F, Hajjar RJ. Antisense strategies for the treatment of heart failure. In: Phillips I, editor. Methods Mol Med. 2005;106:69-82. PMID: 15375313
  11. Gorza L, del Monte F. Protein unfolding in cardiomyopathies. Heart Failure Clinic, Elsevier Saunders. Editors; Hajjar RJ, del Monte F (Guest), Narula J, Young JB (consulting): 237-250. Heart Fail Rev. 2008 Jun;13(2):151-62. doi: 10.1007/s10741-007-9071-9. PMID: 18347978
  12. Lebeche D, Dalal R, Jang M, del Monte F, Hajjar RJ. Transgenic models of Heart failure: Elucidation of the Molecular Mechanisms of Heart Disease. Heart Failure Clinic, Elsevier Saunders. Editors; Hajjar RJ, del Monte F (Guest), Narula J, Young JB (consulting): 219-236. PMID: 17386849
  13. Hajjar RJ, del Monte F Guest Editors: Heart Failure Clinic, Elsevier Saunders. Editors; Narula J, Young JB (Consulting Editor)
  14. del Monte F, Kizana E, Tabchy A, Hajjar RJ. Targeted gene transfer in heart failure: implications for novel gene identification. Curr Opin Mol Ther. 2004 Aug; 6(4): 381-94. PMID: 15468597
  15. Coggins M, Haring B**, del Monte F. Excitation-Contraction Coupling Mechanisms in Heart Failure, Heart Failure, Second Edition, Semigran MJ, Shin JT Editors, Informa Healthcare USA, Inc. 2012.

Reviews

  1. Alessandri N, Pannarale G, del Monte F, Moretti F, Marino B, Reale A. Hypertrophic obstructive cardiomyopathy and infective endocarditis: a report of seven cases and a review of the literature. Eur Heart J 1990; 11 (n): 1041-1048. PMID: 2282924
  2. 111. Puddu PE, del Monte F, Reale A. Cronorischio e morte improvvisa: orizzonte nuovo per la ricerca. Cardiologia 1989; 34 (3): 191-194.
  3. 112. del Monte F, Harding SE, Puddu PE, Poole-Wilson PA. Isolated cardiac myocytes: preparation and use in experimental cardiology. Cardiologia 1991; 36 (4): 319-329. PMID: 1933961
  4. 113. Harding SE, del Monte F, Poole-Wilson PA. Relaxation abnormalities in myocytes isolated from human ventricle. Proceedings IUPS, Glasgow, Scotland, 1993.
  5. 114. Harding SE, Davia K, Davies CH, del Monte F, Money-Kyrle AR, Poole-Wilson PA. From overload to failure: What happens inside the myocyte. Ann Med 1998; 30 (suppl1): 14-23. PMID: 9800879
  6. 115. Force TL, Hajjar RJ, del Monte F, Rosenzweig A, Choukroun G**. Signaling pathways mediating the response to hypertrophic stress in the heart. Gene Express 1999; 7: 337-348. PMID: 10440234
  7. 116. Hajjar RJ, del Monte F, Matsui T, Rosenzweig A. Prospects for gene therapy for heart failure. Circ Res 2000; 86: 616-621. PMID: 10746995
  8. 117. del Monte F, Hajjar RJ, Harding SE, Inesi G. Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure. Circ Res 2001; 88: e66-e67. PMID: 11397790
  9. 118. Kaprielian R, del Monte F, Hajjar RJ. Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer. Basic Res Cardiol (suppl.) 2002; 97:136-145. PMID: 12509478
  10. 119. Huq F, del Monte F, Hajjar RJ. Modulating signaling pathways in hypertrophy and heart failure by gene transfer. J Cardiac Fail 2002; 8 (6): S389-S400. PMID: 12555151
  11. 120. Harding SE, del Monte F. Dissociation of hypertrophic growth from changes in myocyte contractile function. J Cardiac Fail 2002: 8 (6): S415-S420. PMID: 12555154
  12. 121. del Monte F, Johnson CM, Stephanek BA, Doye BA, Gwathmey JK. Defects in calcium control. J Cardiac Fail 2002: 8 (6): S421-S431. PMID: 12555155
  13. 122. del Monte F, Hajjar RJ. Targeting calcium cycling proteins in heart failure through gene transfer. J Physiol (London) 2003; 546: 49-61. PMID: 12509478
  14. 123. del Monte F, Hajjar RJ. Efficient viral gene transfer to rodent hearts in vivo. Methods Mol Biol 2003;219:179-93. PMID: 12597008
  15. 124. Bernecker O, del Monte F, Hajjar RJ. Gene therapy for the treatment of heart failure calcium signaling. Semin Thoracic Cardiovasc Surg 2003; 15 (3):268-76. PMID: 12973704
  16. 125. Chaudri BB, del Monte F, Harding SE, Hajjar RJ. Gene transfer in cardiac myocytes. Surg Clin North Am. 2004: 84 (1) 141-59. PMID: 15053187
  17. 126. del Monte F, Kizana E, Tabchy A, Hajjar RJ. Targeted gene transfer in heart failure: implications for novel gene identification. [http://www.ncbi.nlm.nih.gov/pubmed/15468597] Curr Opin Mol Ther. 2004 Aug;6(4):381-94. Review. PMID:15468597
  18. 127. Harding SE, del Monte F, Hajjar RJ. Antisense strategies for treatment of heart failure. Methods Mol Med. 2004; 106:69-82. PMID:15375313
  19. 128. Bukhari F, Macgillivray T, del Monte F, Hajjar RJ. Genetic maneuvers to ameliorate ventricular function in heart failure: therapeutic potential and future implications. Expert Rev Cardiovasc Ther. 2005 Jan; 3(1):85-97. PMID: 15723577
  20. 129. Gianni D**, Chan J**, Gwathmey JK, , Hajjar RJ. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16691468&query_hl=21&itool=pubmed_docsum] SERCA2a in heart failure: role and therapeutic prospects. J Bioenerg Biomembr. 2005, Dec; 37(6): 375-80. PMID: 16691468
  21. 130. del Monte F, Hajjar RJ. Intracellular devastation in heart failure. Heart Fail Rev. 2008 Jun;13(2):151-62. doi: 10.1007/s10741-007-9071-9. PMID: 18347978
  22. 131. del Monte F, Agnetti G. Protein post-translational modifications and misfolding: new concepts in heart failure. Proteomics Clin Appl. 2014 Aug;8(7-8):534-42. PMID: 24946239
  23. 132. del Monte F, Ishikawa K, Hajjar RJ. Gene Transfer to Rodent Hearts In Vivo. Methods Mol Biol. 2017;1521:195-204. PMID: 27910050.
  24. Professional educational materials or reports, in print or other media [http://cv.hms.harvard.edu/index.php?page=print]
  25. HMS Cardiovascular Physiology Course, Annual teaching material published on MIT website for Undergraduate, Graduate and MD/PhD students

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