Qualificazioni Academiche
University Pierre et Marie Curie, Paris, France. Docteur ès Sciences (PhD) Summa cum Laude (1996)
University La Sapienza, Rome, Italy, Laurea in Fisica, Summa cum Laude (theoretical condensed matter physics) (1990)
Argomenti di ricerca
Soft matter theoretical physics, computational physics applied to macromolecules, protein dynamics, protein folding, protein-protein interactions, development of methods for path sampling and free energy calculation, proteomics, modelling and interpretation of biophysical experimental data (mass spectrometry, NMR, small angle X-ray scattering, crystallography, single molecule force spectroscopy, cryo electron microscopy, kinetics, mutagenesis)
Posizioni
2021-: Università di Bologna. Professore associato. Dipartimento di Fisica e Astronomia
2004 - 2021: University of Leeds. Associate Professor (at School of Physics and Astronomy until 2007, then School of Molecular and Cellular Biology).
2001 - 2004: Institute of Biochemistry, University of Zurich, Switzerland. Oberassistent.
1996 - 2001: Institut le Bel, University of Strasbourg, France. Post-doctoral research fellow (with M. Karplus)
1996 - 2001: Oxford Centre for Molecular Sciences. Post-doctoral visiting research fellow (with C. Dobson)
1993 - 1996: Commisariat à l’Energie Atomique, Saclay, France. Post-graduate research associate (supervisors M. Marchi and P. Turq)
1991 - 1993: Centre Européen de Calcul Atomique et Moléculaire, Orsay, France. Post-graduate research associate (with G. Ciccotti)
Fellowships
1999 - 2001 Marie Curie Post-doctoral Fellowship
1997 - 1999 Human Frontier Science Programme Post-doctoral Fellowship
Seminari e lezioni in conferenze internazionali (selezione)
January 2018, Protein folding dynamics Gordon Research Conference, Galveston, TX, USA
June 2017, Computational Aspects of Biomolecular NMR Gordon Research Conference, Sunday River, ME, USA
February 2017, Biophysical Society Annual Meeting, New Orleans
December 2016, International Conference on Computational Science and Engineering, Ho-Chi-Minh, Vietnam.
November 2015, Deep Carbon Observatory “Molecular adaptation to life at extremes”, Geophysical Laboratory of the Carnegie Institution of Washington, DC, USA
August 2015, CECAM workshop “Intrinsically Disordered Proteins - Bringing together Physics, Computation and Biology”, ETH Zurich
June 2015, Proteins Gordon Research Conference Holderness, NH, USA
June 2014, SocBin2014, International Conference Bioinformatics 2014, Toruń, Poland
Organizzazione di conferenze e workshops
October 29-November 1, 2017 “Computational approaches to investigating allostery” (with S. Wodak and N. Dokholyan), EPFL, Lausanne.
February 14-19, 2016, “Models for protein dynamics 1976-2016” (with D. Tildesley and B. Roux), EPFL, Lausanne
October 12-14, 2015, “Free energy landscapes for protein folding. Consensus or dissensus?” (with A Caflisch and S. Krivov), ETH-Zurich
April 12-15, 2011, "Multiscale computational biomechanics" (with F Gräter), ETH-Zurich
September 19-22, 2006 "Protein folding and misfolding: Bringing theory close to experiment" (with M. Vendruscolo), Lyon, France
Sept 26-29, 2006, "Theory of single molecule force experiments and simulations" (with P. Olmsted and R. Best), Lyon, France
Sept 9-12, 2003, "Protein folding: Bringing theory and experiment closer together" (with M. Vendruscolo), Lyon, France
Finanziamenti attuali
Does functional misfolding of TonB drive import across the outer membrane of Gram negative bacteria? BBSRC, D. Brockwell (PI), E. Paci, T. Karamanos (Co-I) (04/22-03/25) £600,000
Exploiting the SARS-CoV-2 nsp14 3′-5′-exoribonuclease as a target for antiviral chemotherapy, MRC-UKRI Covid-19 call. M. Harris (PI), E Paci (co-I) £260,000
Design of novel vectors for gene therapy, Innovate UK-Freeline Therapeutics Ltd E. Paci (PI) (01/20-12/23) £327,348
Rational design of dynamic molecules for enhanced multivalent binding, Leverhulme Trust, Paci E (PI), Turnbull B (co-I) (01/19-12/22) £248,699
Finanziamenti passati (selezione)
Phosphodependent helix switches in cellular signalling, BBSRC BB/S00730X/1 Bayliss R (PI), Paci E (co-I) (01/19-12/21) £640,001
Synthetic Glycobiology - new strategies to build and functionalise proto-cells and proto-tissues, ERASynBio ERA‐Net: ERASYNBIO1-050, acronym: SynGlycTis, , Turnbull B (PI), Paci, E et al. (co-I), awarded (09/2014-08/2017), € 2,500,000
Single Alpha Helical Domains: Designing Artificial Levers for Biological Molecules, BBSRC, Peckham M (PI), Paci E et al. (co-I), 01/2012-12/2014, ₤ 900,000
The thermodynamics and kinetics of proteins under tension Wellcome Trust 4 years studentship for Gael Radou, 10/2012-09/2015, £130,000
Theoretical and experimental study of the molecular mechanism of protein folding, misfolding and aggregation and possible connection with disease Paci E , Vriend G, Finkelstein AV, Darinskii AL, Bichkova VI. INTAS project 05-1000004-7747 (€ 150,000)
The mechanism of amyloid formation in a model peptide Wales D, Dobson CM, Vendruscolo M, Paci E , BBSRC (BB/D000718/1) (₤ 223,000)
Insegnamento
Attuale.
Physics (85289, Laurea in "Genomics", FaBiT)
Physical methods of biology (87995, Second cycle degree in "Physics", DIFA)
Passato
Undergraduate: Lecturing for the Biochemistry BSc programme, level 1, 2, 3 (topics: Bioinformatics, Thermodynamics, Protein dynamics). Supervision of BSc (level 3) and MSc (level 4) final projects. Module management for 15 level 3 modules (final projects and advanced topics). Graduate: lectures on a number of biophysical topics for the Wellcome Trust doctoral programme “The Molecular Basis of Biological Mechanisms”.
Programme leader and lecturer for the MSc Bioinformatics (2008-2013). Lecturing for the “Statistical Mechanics” module at the School of Physics and Astronomy, University of Leeds, leader of the postgraduate course “Biomolecular simulation” at the Department of Biochemistry, University of Zurich. I participated as lecturer to a number of summer schools across Europe.
Altre attività
Regularly review manuscript for reputable journals in the field (including Nature, PNAS, JACS, PRL, JCP, JPCB, JMB, Proteins, Biophysical J, J Comp Chem, JCTC) and grant proposal for UK funding agencies (BBSRC, EPSRC, MRC, Wellcome, Leverhulme) and international funding agencies (Germany, Switzerland, Holland, France, USA, Ireland, Poland, EU). Member of the visiting committee evaluating the Structural Biology Department of Institut Pasteur, Paris in 2010 and Institut de Biologie Structurale, Grenoble in 2014. Member of the selection committee for a professorship at University of Barcelona. Academic editor of PLoS ONE, Biomedical Physics and Bioengineering Express (IOP) and PeerJ.
Supervisione PhD
- Molecular modelling of the GLP-1 receptor – a prototypic family B GPCR, Carla Gomez-Santiago, 2020
- Investigation of mechano-transduction across bacterial protein networks, Sam Hickman, 2016
- Helicase Functional Dynamics Probed with Low-Resolution Experimental Data and Simulation, Gael Radou, 2015
- In-silico investigation of ion-pumping rotatory A- and V-type ATPases, Konstantinos Papachristos, 2014
- Synthetic design capsid-like particles, James Ross, 2014
- High-dimensional models of protein folding, Supreecha Rimratchada, 2012
- Dynamics and Thermodynamics of Protein-Ligand Interactions, Richard Malham, 2011
- Enhancing the interpretation of dynamic force spectroscopy experiments, Zu Thur Yew, 2010
- Free energy landscapes of proteins: combining experimental data with numerical simulation, Lucy Allen, 2009
- The effects of local dynamics and geometry on protein mechanical unfolding behaviour, Dan West, 2006
- Computational studies of protein binding and peptide aggregation, Raffaele Curcio, 2006
Publications [https://scholar.google.com/citations?hl=en&user=J1Ehb3AAAAAJ]
