Foto del docente

Davide Martelli

Senior assistant professor (fixed-term)

Department of Biomedical and Neuromotor Sciences

Academic discipline: BIO/09 Physiology

Curriculum vitae

CV – Davide Martelli

RTD-A at DIBINEM - UNIBO

Qualified for the position of Associate Professor of Physiology in Italy (2017-2023)

PERSONAL INFORMATION

Family name, First name: Martelli, Davide

Date of birth: 20/10/1976

URL for web site: http://scholar.google.it/citations?user=t-3NrDcAAAAJ&hl=en

BIOGRAPHY

Davide Martelli is born in Medicina-Bologna, Italy, on the 20th of October 1976. After his graduation in Biology (2003), he started his doctoral studies at the University of Bologna investigating the neurophysiological control of the wake-sleep cycle. It is during these years (2005-2009) that he demonstrated how REM sleep is associated with a fully operant osmoregulatory control but an impairment of thermoregulation. In the following two years (2009-2010), during his postdoctoral studies, he revealed that the inhibition of neurons in the raphé pallidus induces a suspended animation-like state in the rat. In December 2010, he moved to the Florey Institute in Melbourne, Australia, where he began his studies on the neural control of immune function. It is from this research that he identified the existence of a neural reflex that controls inflammation. The efferent motor pathway of this reflex is purely sympathetic and travels into the splanchnic sympathetic nerves. In February 2016 he moved back to the University of Bologna where he became Assistant Professor in Physiology. Davide has won several awards and grants, amongst them the early career/postdoctoral investigator award from the American Physiological Society in 2014, an IBRO fellowship and a National Health and Medical Research Council (NHMRC of Australia) Research Grant, both in 2015. He is member of the American Physiological Society and the International Society for Autonomic.

PUBLICATIONS

2018

  1. Komegae E.N., Farmer D.G.S., Broks V.L., McKinley M.J., McAllen R.M., Martelli D.Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway. Brain Behavior and Immunity. 2018. In press.
  2. McKinley M.J., Martelli D., Pennington G.L., Trevaks D., McAllen R.M. Integrating the competing demands of osmoregulatory and thermoregulatory homeostasis. Physiology. 33 (3), 2018: 170-181.

    2017

  3. Luppi M., Al-Jahmany A.A., Del Vecchio F., Cerri M., Di Cristoforo A., Hitrec T., Martelli D., Perez E., Zamboni G., Amici R. Wake-sleep and cardiovascular regulatory changes in rats made obese by a high-fat diet. Behav. Brain Res. 320, 2017: 347-355.

    2016

  4. Martelli D., Farmer D.G., Yao S.T. The splanchnic anti-inflammatory pathway: Could it be the efferent arm of the inflammatory reflex? Exp. Physiol. 101(10), 2016: 1245-1252.

    2015

  5. Anderson C.R., McKinley M.J., Martelli D., McAllen R.M. Letter to the editor: Parasympathetic innervation of the rodent spleen? Am. J. Physiol. Heart Circ. Physiol., 309(12), 2015: H2158.
  6. McKinley M.J., Yao S.T., Uschakov A., McAllen R.M., Rundgren M., Martelli D. The median preoptic nucleus: front and centre for regulation of body fluid, sodium, temperature, sleep and cardiovascular homeostasis. Acta Physiologica, 214(1), 2015: 8-32.
  7. McAllen R.M., Cook A.D., Khiew H.W., Martelli D., Hamilton J.A. The interface between cholinergic pathways and the immune system and its relevance to arthritis. Arthritis Res. Ther., 17(1) 2015: 87.
  8. Martelli D., Silvani A., McAllen R.M., May C.N., Ramchandra R. Reply to “Letter to the editor: Does low-frequency power of heart rate variability correlate with cardiac sympathetic tone in normal sheep?”. Am. J. Physiol. Heart Circ. Physiol. 308(2), 2015:H148-9.

    2014

  9. Cerri M., Del Vecchio F., Mastrotto M., Luppi M., Martelli D., Perez E., Tupone D., Zamboni G., Amici R. Enhanced Slow-Wave EEG Activity and Thermoregulatory Impairment following the Inhibition of the Lateral Hypothalamus in the Rat. Plos One, 9(11), 2014: e112849.
  10. Martelli D., Yao S.T., Mancera J., McKinley M.J., McAllen R.M. Reflex control of inflammation by the splanchnic anti-inflammatory pathway is sustained and independent of anaesthesia. Am. J. Physiol. Regul. Int. Comp. Physiol. 307(9), 2014: R1085-91.
  11. Martelli D., Silvani A., McAllen R.M., May C.N., Ramchandra R. The low frequency power of heart rate variability is neither a measure of cardiac sympathetic tone nor of baroreflex sensitivity. Am. J. Physiol. Heart Circ. Physiol. 307(7), 2014:H1005-12.
  12. Martelli D., Yao S.T., McKinley M.J., McAllen R.M. Neural control of inflammation by the greater splanchnic nerves. Temperature. 2014 Epub: http://www.tandfonline.com/doi/full/10.4161/temp.29135
  13. Martelli D., Yao S.T., McKinley M.J., McAllen R.M. Reflex control of inflammation by sympathetic nerves, not the vagus. J. Physiol., 592, 2014:1677-1686.

    Note: This article has been recommended in F1000Prime (Faculty of 1000); Jänig W: F1000Prime Recommendation of [Martelli D et al., J Physiol (Lond) 2014]. In F1000Prime, 06 Feb 2014;

    DOI: 10.3410/f.718236549.793490418. F1000Prime.com/718236549#eval793490418.

    Note: This article was the editor’s choice of the published issue.

  14. Martelli D., Luppi M., Cerri M., Tupone D., Perez E., Zamboni G., Amici R. The Direct Cooling of the Preoptic-Hypothalamic Area Elicits the Release of Thyroid Stimulating Hormone during Wakefulness but Not during REM Sleep. Plos One, 9(2), 2014: e87793.
  15. Martelli D., McKinley M.J., McAllen R.M. The cholinergic anti-inflammatory pathway: a critical review. Auton. Neurosci., 182, 2014:65-69.
  16. Luppi M., Cerri M., Martelli D., Tupone D., Del Vecchio F., Di Cristoforo A., Perez E., Zamboni G., Amici R. Waking and sleeping in the rat made obese through a high-fat hypercaloric diet. Behav. Brain Res., 258C, 2014:145-152.

    2013

  17. Martelli D., Stanic D., Dutschman M. The emerging role of the parabrachial complex in the generation of wakefulness drive and its implication for respiratory control. Respir. Physiol. Neurobiol., 188(3) 2013: 318-23.
  18. Cerri M., Mastrotto M., Tupone D., Martelli D., Luppi M., Perez E., Zamboni G., Amici R. The inhibition of neurons in the central nervous pathways for thermoregulatory cold defense induces a suspended animation state in the rat. J. Neuroscience., 33(7), 2013: 2984-93.

    2012

  19. Martelli D., Luppi M., Cerri M., Tupone D., Perez E., Zamboni G., Amici R. Waking and sleeping following water deprivation in the rat. Plos One, 7(9), 2012:e46116.
  20. *Bratton B.O., *Martelli D., McKinley M.J., Trevaks D., Anderson C.R. and McAllen R.M.. Neural regulation of inflammation: no neural connection from the vagus to splenic sympathetic neurons. Exp. Physiol., 97(11), 2012: 1180-5.

    Note: This article was the topic of an editorial; Exp Physiol. 2012 Nov;97(11):1178-9. doi: 10.1113/expphysiol.2011.064071. The inflammatory reflex: the current model should be revised. Romanovsky AA.

    2010

  21. Luppi M., Martelli D., Amici R., Baracchi F., Cerri M, Dentico D., Perez E., Zamboni G. Hypothalamic osmoregulation is maintained across the wake-sleep cycle in the rat. J. Sleep Res., 19(3), 2010: 394-399.
  22. Cerri M., Zamboni G., Tupone D., Dentico D., Luppi M., Martelli D., Perez E., Amici R. Cutaneous vasodilation elicited by disinhibition of the caudal portion of the rostral ventromedial medulla of the free-behaving rat. Neuroscience, 165 (3), 2010: 984 995.

    2009

  23. Dentico D., Amici R., Baracchi F., Cerri M., Luppi M., Martelli D., Perez E., Zamboni G. c-Fos expression in preoptic nuclei as a marker of sleep rebound in the rat. Eur. J. Neuroscience, 3 (4), 2009: 651-661.

EDUCATION

25/05/2009 PhD in Neurophysiology

Dept. of Human and General Physiology, University of Bologna, Italy.

14/03/2003 Master Biological Sciences – Biomolecular address, University of Bologna, Italy (degree score 110/110)

CURRENT POSITION(S)

18/02/2016 – Today Assistant Professor

Dept. of Biomedical and Neuromotor Science (DIBINEM), University of Bologna, Italy

01/02/2013 – Today Senior Research Officer

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia

PREVIOUS POSITIONS

05/09/2012 – 31/01/2013 Postdoctoral Researcher

Dept. of Human and General Physiology (now DIBINEM), University of Bologna, Italy.

01/12/2010 – 04/09/2012 Visiting Fellow

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia

25/05/2009 – 30/11/2010 Postdoctoral Researcher

Dept. of Human and General Physiology, University of Bologna, Italy.

FELLOWSHIPS PRIZES AND AWARDS

2018: Selected for the symposium “Featured Topic - NCAR Hot Topics in Autonomic Regulation” sponsored by the American Physiological Society. EB2018. San Diego, California USA, April 21-25, 2018.

2015: Awarded with a IBRO Fellowship (10.000 EUR)

2014: Best original review published in 2013 at the Florey (from the Florey Postdoctoral Association). Melbourne, Victoria, Australia.

2014: Merck-Millipore travel award, Melbourne, Victoria, Australia to attend EB2014 in San Diego, USA.

2014: F1000 (Faculty of 1000) Reccomendation: Jänig W: F1000Prime Recommendation of [Martelli D et al., J Physiol (Lond) 2014]. In F1000Prime, 06 Feb 2014; DOI: 10.3410/f.718236549.793490418. F1000Prime.com/718236549#eval793490418.

2014: “Post-doctoral/Early Career Investigator Award” from the American Physiological Society (Neural Control/Autonomic Regulation section). San Diego, California, USA.

2013: “Best oral presentation” at the annual meeting of the Florey Postdoctoral Association. Melbourne, Victoria, Australia.

2012: “Best communication at a conference” from the Florey Postdoctoral Association, Melbourne, Victoria, Australia.

2011: IBRO travel grant (1.250 EUR) to participate to the 8th IBRO world congress (14-18, July 2011, Firenze, Italy).

2010: Travel grant (500 EUR) to participate to the 20th meeting of the ESRS (14-18, September 2010, Lisboa, Portugal).

2010: Post-Doctoral fellowship at the Department of Human and General Physiology, University of Bologna, Italy.

2009: European Marie Curie scholarship to participate at the European Marie Curie Action “Training in Sleep Research and Sleep Medicine” organized by the European Sleep Research Society (ESRS).

2008: Scholarship at the Department of Human and General Physiology, University of Bologna, Italy.

2004: National ministerial scholarship to frequent the doctorate in Neurophysiology at the University of Bologna, Italy.

2003: Scholarship at the Department of Human and General Physiology, University of Bologna, Italy.

2000: European Socrates/Erasmus scholarship (6 months at the University of Bödenkultur, Vienna, Austria)

FUNDING RECEIVED SO FAR

2015: Chief Investigator A (PI) – NHMRC Australian Research Project Grant – GNT1098887 (613.466 AUD).

2011: Winner of a “Medical research & Technology equipment grant” (24.150 AUD) offered by The William Buckland Foundation.

2010: Recipient of a European Research Grant (15.000 EUR) offered by Sanofi-Aventis for the European Sleep Research Society (ESRS).

2009: Co-Investigator - Italian Ministerial grant PRIN 2009 - prot. 2009SPTHRK_001 (62.262 EUR).

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

2016-Now: 2 PostDoc, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, 2 PhD students at DIBINEM and 2 Master students at DIBINEM

2015-2016: 2 Master students, DIBINEM, University of Bologna, Italy

2012-2015: 2 PhD students and 1 Medical Doctor trainee, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia

2009: 1 PhD student, Dept. of Human and General Physiology, University of Bologna, Italy

2008: 1 Master student, Dept. of Human and General Physiology, University of Bologna, Italy

ORGANISATION OF SCIENTIFIC MEETINGS

2015: Organizer, Chair and Speaker in a symposium held during the ISAN2015 conference of the International Society for Autonomic Neuroscience in conjunction with Federation of European Autonomic Societies, American Autonomic Society and Japan Society of Neurovegetative Research (Stresa, Italy, September 26-29, 2015) – Symposium Title: “Nervous about inflammation? How the autonomic nervous system influences immune function”. Sponsored by Experimental Physiology. Speakers: Davide Martelli, Ruud Buijs, Georg Pongratz.

2011, 2013: Chairman at the Florey postdoctoral annual meetings. Melbourne. VIC Australia.

2010: Chairman at the oral blitz session on basic research in sleep, final symposium of the Marie Curie Action “Training in sleep research and sleep medicine”. Kloster Seeon, Germany, 02-06 July 2010.

2010: Chairman at the symposium held at the Department of Human and General Physiology, University of Bologna (Italy), within the European Marie Curie Action “Sleep Research and Sleep Medicine Education Program” organized by the European Sleep Research Society (ESRS).

INSTITUTIONAL RESPONSIBILITIES

2017 - Today: Docent of Systems Physiology (faculty of medicine, school of medicine) and docent of nutrition physiology (faculty of medicine, nutrition sciences course), University of Bologna.

2016: Docent of Systems Physiology (faculty of medicine, school of medicine), University of Bologna.

2014: Part of the School Outreach Team of the Florey Institute of Neuroscience and Mental Health. During the Brain Awareness Week (March 2014), I was invited to give a talk on the Neurobiology of Sleep at a local High School in Melbourne.

2014: Nominated from The Florey Institute as post-doctoral representative to attend the First Commonwealth Science Conference in Bangalore, India (25-28 November 2014).

COMMISSIONS OF TRUST

2018: Member of the commission for the MPhil in Medical Science for the candidate Flavia Peci. Department of Hematology, University of Cambridge

2013-2016: Member of the panel for doctorate supervision at the University of Melbourne for the PhD candidate Giancarlo Allocca

2014-Now: Editorial Board of the Journal of Immune Research

Invited Peer-Reviewer for the following journals: Neurogastroenterology and Motility, Brain Behavior and Immunity, Clinical and Experimental Pharmacology and Physiology, Journal of Neurophysiology, Autonomic Neuroscience: Basic and Clinical, Brain Behavior and Immunity, American Journal of Physiology (Reg. Integr. Comp. Physiol.).

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

Italian Society for Neuroscience (2011-Now), Federation of European Neuroscience Societies (2011-Now), Australasian Society for Neuroscience (2011-2014), Society for Neuroscience (2013-2014), American Physiological Society (2013-Now), International Society for Autonomic Neuroscience (2014-Now).

MAJOR COLLABORATIONS

Robin McAllen, David Farmer, Michael McKinley, Song Yao, Neural control of immunity, Florey Institute of Neuroscience and Mental Health, Australia. Erica Sloan, Cancer and autonomic nervous system, Monash University, Australia. Clive May, Lindsea Booth, Yugeesh Lankadeva Heart failure and sepsis, Florey Institute of Neuroscience and Mental Health, Australia. Rohit Ramchandra, Heart failure, University of Auckland, New Zealand. John Hamilton, Andrew Cook, Rheumatoid arthritis, University of Melbourne, Australia. Andrew Gundlach, Relaxin control of the wake-sleep cycle, Florey Institute of Neuroscience and Mental Health, Australia.

INVITED PRESENTATIONS

Invited seminars:

  1. University of Helsinki – The inflammatory reflex – Helsinki, Finland. 11/03/2016.
  2. University of Bologna - Neural control of immune function: The inflammatory reflex – Bologna, Italy. 23/04/2015.
  3. Flinders University - Neural Control of Immune Function - Adelaide, SA Australia. 08 May 2013.
  4. University of Sydney - Thermoregulatory but not Osmoregulatory impairment characterizes REM Sleep - Sydney, NSW Australia. 04/11/2011
  5. Florey Institutes Neuroscience Seminar Series - Physiological regulations during the wake sleep cycle - Howard Florey Institute, Melbourne, VIC Australia, 28 June 2011.

Oral Communications:

  1. EB 2018. Invited speaker in the symposium “Featured Topic - NCAR Hot Topics in Autonomic Regulation”. San Diego, California USA, April 21-25, 2018.

  2. ISAN 2017. Invited speaker in the symposium “Targeting the autonomic nervous system to alleviate inflammatory disorders". Nagoya, Japan, Aug 30 – Sep 2, 2017.

  3. EB 2017. Invited speaker in the symposium “Sympathetic Nerves and Inflammation: The Pro and the Anti”. Chicago, IL, USA, April 22-26, 2017
  4. International Society for Autonomic Neuroscience (ISAN) 2015. Stresa, Italia, 26-29 September 2015.
  5. Central Cardiovascular Respiratory Control: Future Directions. Melbourne, VIC Australia, 15-16 September 2014.
  6. Experimental Biology (EB) 2014. San Diego, California USA, 26-30 April 2014.
  7. Florey Postdoctoral Annual Meetings 2011, 2013.
  8. 20th international congress of the European Sleep Research Society. Lisbon, Portugal, 14-18 September 2010.
  9. Central Cardiovascular Control: Future Directions. Melbourne, VIC Australia, 20-21 October 2011.
  10. Marie Curie Action “Training in sleep research and sleep medicine”. Kloster Seeon, Germany, 02-06 July 2010.
  11. PENS – Marie Curie Summer school. Bertinoro (FC), Italy, 08-13 May 2009.
  12. First annual meeting of Italian PhD students in physiology. Pontignano (Si), Italy, 18-21 July 2007.

Poster Communications:

I participated to several National and International meetings or conferences with poster communications. Amongst them:

  1. 8th IBRO world congress. Firenze, Italy, 14-18, July 2011
  2. 33rd Meeting of the Australian Neuroscience Society (ANS). Melbourne, VIC Australia, 3-6, Feb 2013
  3. Experimental Biology (EB) 2014, 2017. USA.

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