vai alle Pubblicazioni
Publications prior to 2004
Published papers (1995-2017)
- Croco E, Marchionni S, Bocchini M, Angeloni C, Stamato T, Stefanelli C, Hrelia S, Sell C, Lorenzini A. DNA Damage Detection by 53BP1: Relationship to Species Longevity. Journal of Gerontology A Biol Sci Med Sci. 2017 72 763-770 (2017)
- Jürimäe J, Tillmann V, Cicchella A, Stefanelli C, Võsoberg K, Tamm AL, Jürimäe T. Increased sclerostin and preadipocyte factor-1 levels in prepubertal rhythmic gymnasts: associations with bone mineral density, body composition, and adipocytokine values. Osteoporosis International. 27 1239-1243 (2016)
- Bartolomei S, Hoffman JR, Stout JR, Zini M, Stefanelli C, Merni F. Comparison of block versus weekly undulating periodization models on endocrine and strength changes in male atheletes. Kinesiology. 48 71-78 (2016)
- Pinna C, Vecchiato CG, Zaghini G, Grandi M, Nannoni E, Stefanelli C, Biagi G. In vitro influence of dietary protein and fructooligosaccharides on metabolism of canine fecal microbiota. BMC Veterinary Research 12 53 (2016).
- Cappadone C, Stefanelli C, Malucelli E, Zini M, Onofrillo C, Locatelli A, Rambaldi M, Sargenti A, Merolle L, Farruggia G, Graziadio A, Montanaro L, Iotti S. p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells. Biochemical and Biophysical Research Communications 467 348-353 ( 2015)
- Leoni A, Locatelli A, Morigi R, Rambaldi M, Cappadone C,
Farruggia G, Iotti S, Merolle L, Zini M, Stefanelli C. Substituted
E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with
antiproliferative activity. Study of the effects on HL-60 leukemia
cells. Europen Journal of Medicinal Chemistry 79:382-390
(2014).
- Borzì RM, Guidotti S, Minguzzi M, Facchini A, Platano D,
Trisolino G, Filardo G, Cetrullo S, D'Adamo S, Stefanelli C,
Facchini A, Flamigni F. Polyamine delivery as a tool to modulate
stem cell differentiation in skeletal tissue engineering. Amino
Acids 46(3):717-28 (2014)
- Pinna C, Stefanelli C, Biagi G. In vitro effect of
dietary protein level and nondigestible oligosaccharides on feline
fecal microbiota. Journal of Animal Science
92(12):5593-602 (2014).
- Cicchella A, Jürimäe T, Stefanelli C, Purge P, Lätt E,
Saar M. Correlations of skinfold thicknesses and
circumferences at exactly defined body sites with leptin in
10-12-year-old boys with different BMIs. Collegium
Antropologicum 38(2):459-65 (2014).
- Minarini A, Zini M, Milelli A, Tumiatti V, Marchetti C,
Nicolini B, Falconi M, Farruggia G, Cappadone C, Stefanelli C.
Synthetic polyamines activating autophagy: effects on cancer cell
death. European Journal of Medicinal Chemistry
67:359-66 (2013)
- Cicchella A, Stefanelli C, Jürimäe T, Saar M, Purge P.
Moderate physical activity correlates with elevated leptin in
physically active 10-12-year-old boys with normal BMI.
Perceptual Motor Skills 117(2):358-66 (2013)
- Cicchella A, Stefanelli C, Purge P, Lätt E, Saar M,
Jürimäe T. The associations between peak O2 onsumption and leptin
in 10- to 12-year-old boys. Clinical Physiology and Functional
Imaging 33(4):313-6 (2013)
- Biagi G, Cipollini I, Bonaldo A, Grandi M, Pompei A,
Stefanelli C, Zaghini G. Effect of feeding a selected
combination of galacto-oligosaccharides and a strain of
Bifidobacterium pseudocatenulatum on the intestinal microbiota of
cats. American Journal of Veterinary Research
74(1):90-5 (2013)
- Milelli A, Tumiatti V, Micco M, Rosini M, Zuccari G,
Raffaghello L, Bianchi G, Pistoia V, Fernando Díaz J, Pera B,
Trigili C, Barasoain I, Musetti C, Toniolo M, Sissi C, Alcaro S,
Moraca F, Zini M, Stefanelli C, Minarini A. Structure-activity
relationships of novel substituted naphthalene diimides as
anticancer agents. European Journal of Medicinal Chemistry
57:417-28 (2012)
- Passariello CL, Gottardi D, Cetrullo S, Zini M, Campana
G, Tantini B, Pignatti C, Flamigni F, Guarnieri C, Caldarera CM,
Stefanelli C. Evidence that AMP-activated protein kinase can
negatively modulate Ornithine decarboxylase activity in cardiac
myoblasts. Biochimica et Biophysica Acta
Mol.Cell.Res. 1823 800-807, 2012
- Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi
M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Stefanelli C,
Masotti L, Nguyen TL, Hamel E, Shoemaker RH.
Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones
and Analogues: Synthesis, Cytotoxic Activity, and Study of the
Mechanism of Action . Journal of Medicinal
Chemistry 55 2078-88, 2012
- Cetrullo S, Tantini B, Flamigni F, Pazzini C, Facchini
A, Stefanelli C, Caldarera CM, Pignatti C. Antiapoptotic and
antiautophagic effects of eicosapentaenoic Acid in cardiac
myoblasts exposed to palmitic Acid.
Nutrients 4 78-90, 2012
- R Gruodyte, J Jurimae, M
Saar, A Cicchella, C Stefanelli, C
Passariello, T Jurimae, Bone mineral
density and hormonal status in adolescent girls. Acta
Kinesiologiae Universitatis Tartuensis 18:56-68 (2012)
- Passariello CL, Zini M, Nassi PA, Pignatti C, Stefanelli
C. Upregulation of SIRT1 deacetylase in phenylephrine-treated
cardiomyoblasts. Biochemical and Biophysical Research
Communications 407:512-516, 2011
- Cetrullo S, Tantini B, Facchini A, Pignatti C,
Stefanelli C, Caldarera CM, Flamigni F.
A pro-survival
effect of polyamine depletion on norepinephrine-mediated apoptosis
in cardiac cells: role of signaling enzymes. Amino Acids
40:1127-1137, 2011
- Jürimäe J, Gruodyte R, Saar M, Cicchella A, Stefanelli
C, Passariello C, Maasalu K, Jürimäe T, von Duvillard SP. Plasma
visfatin and adiponectin concentrations in physically active
adolescent girls: relationships with insulin sensitivity and body
composition variables. J Pediatr Endocrinol Metab
24:419-425, 2011
- Passariello CL, Gruodytė R, Hiio K, Mäestu J, Jürimäe J,
Saar M, Cicchella A, Stefanelli C, Jürimäe T.
ADIPOQ SNP45 associated with
lean body mass in physically active normal weight adolescent girls.
American Journal of
Human Biology 22:813-818, 2010
- Muscari C, Capanni C, Giordano E, Stefanelli C, Bonavita
F, Stanic I, Bonafè F, Caldarera CM, Guarnieri C.
Leupeptin preserves cardiac
nitric oxide synthase 3 during reperfusion following long-term
cardioplegia. Journal of Surgical
Research 164:27-35, 2010
- Gruodytė R, Jürimäe J, Cicchella A, Stefanelli C,
Passariello C, Jürimäe T. Adipocytokines
and bone mineral density in adolescent female
athletes. Acta Paediatrica
99:1879-1884, 2010
- Andreani A, Bellini S, Burnelli S, Granaiola M, Leoni A,
Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone
C, Zini M, Stefanelli C, Masotti L, Shoemaker RH.
Substituted
E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor
activity. In depth study of the effect on growth of breast cancer
cells. Journal of Medicinal
Chemistry 53:5567-5575, 2010
- Tumiatti V, Milelli A, Minarini A, Micco M, Gasperi
Campani A, Roncuzzi L, Baiocchi D, Marinello J, Capranico G, Zini
M, Stefanelli C, Melchiorre C.
Design, synthesis, and biological
evaluation of substituted naphthalene imides and diimides as
anticancer agent. Journal of
Medicinal Chemistry 52: 7873-7877, 2009
- M. Zini, C. L. Passariello, D. Gottardi, S. Cetrullo, F.
Flamigni, C. Pignatti , A. Minarini, V. Tumiatti, A. Milelli, C.
Melchiorre, C. Stefanelli. Cytotoxicity of Methoctramine and
Methoctramine-related Polyamines. Chemico-Biological
Interactions 181: 409-416. 2009
- Stanic' I, Facchini A, Borzì RM, Stefanelli C, Flamigni
F. The polyamine analogue N1,N11-diethylnorspermine
can induce chondrocyte apoptosis independently of its ability to
alter metabolism and levels of natural polyamines. Journal
of Cellular Physiology 219:209-216, 2009
- Stanic, S. Cetrullo, A. Facchini, C. Stefanelli, R.M.
Borzì, B. Tantini, C. Guarnieri, C.M. Caldarera, F. Flamigni.
Effect of the Polyamine Analogue N1,N11-
Diethylnorspermine on Cell Survival and Susceptibility to Apoptosis
of Human Chondrocytes. Journal of Cellular
Physiology 216:153-161, 2008
- A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A.
Locatelli, R. Morigi, M. Rambaldi, L. Varoli, N. Calonghi, C.
Cappadone, M. Voltattorni, M. Zini, C. Stefanelli, L. Masotti, R.
H. Shoemaker. Antitumor Activity of New
Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones:
Selectivity Against Colon Tumor Cells and Effect on Cell
Cycle-Related Events. Journal of Medicinal
Chemistry 51:7508-7513, 2008
- A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A.
Locatelli, R. Morigi, M. Rambaldi, L. Varoli, N. Calonghi, C.
Cappadone, G. Farruggia, M. Zini, C. Stefanelli, L. Masotti, N.S.
Radin, R. H. Shoemaker. New Antitumor
Imidazo[2,1-b]thiazole Guanylhydrazones and
Analogs. Journal of Medicinal Chemistry
51:809-816, 2008
- A. Andreani, S Burnelli, M. Granaiola, A Leoni, A
Locatelli, R Morigi, M Rambaldi, L Varoli, N. Calonghi, C
Cappadone, G. Farruggia, M. Zini, C. Stefanelli, L
Masotti. Substituted
E-3-(2-Chloro-3-indolylmethylene)1,3-dihydroindol-2-ones With
Antitumor Activity. Effect on the Cell Cycle and Apoptosis.
Journal of Medicinal Chemistry
50:3167-3172, 2007
- I. Stanic. A. Facchini, R.M. Borzì, R. Vitellozzi, C.
Stefanelli, M.B. Goldring, C. Guarnieri, A. Facchini, F. Flamigni.
Polyamine depletion inhibits apoptosis
following blocking of survival pathways in human chondrocytes
stimulated by Tumor Necrosis Factor- α .
Journal of Cellular Physiology 206:38-146, 2006
- B. Tantini, E. Fiumana, S. Cetrullo, C. Pignatti, F.
Bonavita, L.M. Shantz, E. Giordano, C. Muscari, F. Flamigni, C.
Guarnieri, C. Stefanelli, C.M. Caldarera.
Involvement of polyamines in apoptosis of cardiac myoblasts in a
model of simulated ischemia. Journal of Molecular
and Cellular Cardiology 40:775-782: 2006
- A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A.
Locatelli, R. Morigi, M. Rambaldi, L. Varoli, G. Farruggia, C.
Stefanelli, L. Masotti, M.W. Kunkel.
Synthesis and Antitumor Activity of Guanylhydrazones From
6-(2,4-dichloro-5-nitrophenyl)- and
6-pyridyl-imidazo[2,1-b]thiazole. Journal of
Medicinal Chemistry 49:7897-7901, 2006
- A. Facchini, R.M. Borzì, K.B. Marcu, C. Stefanelli, E.
Olivotto, M.B. Goldring, A. Facchini, F.
Flamigni. Polyamine depletion inhibits
NF-kB binding to DNA and interleukin-8 production in human
chondrocytes stimulated by Tumor Necrosis Factor- α
. Journal of Cellular Physiology
204:956-963, 2005
- C. Muscari,F. Bonafè, I. Stanic, F. Flamigni, C.
Stefanelli, F. Farruggia, C. Guarnieri,C.M.
Caldarera. Polyamine depletion reduces TNF
a /mg132 -induced apoptosis in bone marrow stromal cells.
Stem Cells 23:983-99, 2005
- Dalla Via L, Salvi M, Di Noto V, Stefanelli C, Toninello
A. Membrane binding and transport of
N-aminoethyl-1,2-diamino ethane (dien) and
N-aminopropyl-1,3-diamino propane (propen) by rat liver
mitochondria and their effects on membrane permeability
transition. Molecular Membrane Biology
21:109-118, 2004
- B.Tantini, C. Pignatti, M. Fattori, E. Fiumana, A.
Facchini, C. Stefanelli, C.M. Caldarera, A.E. Pegg, F.
Flamigni. Polyamine depletion inhibits
etoposide-induced NF-kB activation in transformend mouse
fibroblasts. Amino Acids 27:207-214,
2004
- C. Pignatti, B. Tantini, C. Stefanelli, F. Flamigni.
Signal Transduction pathways linking
polyamines to apoptosis. Amino Acids
27:359-365, 2004
- Facchini A, Zanella B, Stefanelli C, Guarnieri C,
Flamigni F. Effect of green tea extract on
the induction of ornithine decarboxylase and the activation of
extracellular signal-regulated kinase in bladder carcinoma ECV304
cells. Nutrition And Cancer 47:104-110,
2003
- C. Pignatti, C. Stefanelli.
Ischemia/reperfusion-induced apoptosis: connecting nitric oxide and
cell cycle regulator. Cardiovascular
Research 59:268-270, 2003
- A. Bonavita, C. Stefanelli, E. Giordano, M. Columbaro,
A. Facchini, F. Bonafè, C.M. Caldarera, C.
Guarnieri. H9c2 cardiac myoblasts undergo
apoptosis in a model of ischemia consisting of serum deprivation
and hypoxia: inhibition by PMA. FEBS
Letters 536:85-91, 2003
- B. Tantini, C. Pignatti, F. Flamigni, C. Stefanelli, M.
Fattori, A. Facchini, E. Giordano, C. Clo and C.M.
Caldarera. Signaling pathways
involved in the stimulation of DNA synthesis by Tumor Necrosis
Facto and Lipopolysaccharide in chick embryo
cardiomyocytes. In:
Signal transduction in cardiac hypertrophy (N.S. Dahalla,
L.V. Hryshko, E. Kardami and P.K. Singal eds) Kluwer, Boston.
359-371, 2003
- C. Stefanelli, C. Pignatti, B. Tantini, E. Giordano, F.
Bonavita, M. Zini, F. Flamigni, C. Muscari, C. Clo, C.M. Caldarera,
C. Guarnieri. Caspase activation in a cardiac
cell-free model of apoptosis. In: Signal
transduction in cardiac hypertrophy (N.S. Dahalla, L.V.
Hryshko, E. Kardami and P.K. Singal eds) Kluwer, Boston. 199-206,
2003
- C. Trevisani, P. Caraceni, M. Simoncini, M. Micati, M.
Domenicali, F. Dazzani, A. Zambruni, C. Stefanelli, G. Grazi , B.
Nardo, C. Guarnieri, M. Bernardi. Evidence
of oxidative imbalance in long-term liver transplant
patients. Digestive and Liver Diseases
34:279-284, 2002
- C. Stefanelli, B. Tantini, M. Fattori, I. Stanic', C.
Pignatti, C. Clo, C. Guarnieri, C.M. Caldarera, C.A. Mackintosh,
A.E. Pegg, F. Flamigni. Caspase activation
in etoposide-treated fibroblasts is correlated to ERK
phosphorylation and both events are blocked by polyamine
depletion. FEBS Letters 527:223-228,
2002
- B. Tantini, C. Pignatti, M. Fattori, F. Flamigni, C.
Stefanelli, E. Giordano, M. Menegazi, C. Clo, C.M.
Caldarera. NF-kB and ERK cooperate to
stimulate DNA synthesis by inducing Ornithine Decarboxylase
and Nitric Oxide Synthase in cardiomyocytes treated with TNF and
LPS. FEBS Letters 451:95-98,
2002
- A. Kowluru, L.M. Modrick, HQ Chen, C. Stefanelli.
Activation of acetyl-CoA carboxylase by a
glutamate and magnesium-sensitive protein phosphatase in the islet
beta-cell. Diabetes 50:1580-1587,
2001
- C. Stefanelli, C. Pignatti, B. Tantini, M.
Fattori, I. Stanic, C.A Mackintosh, F. Flamigni, C. Guarnireri,
C.M. Caldarera, A.E. Pegg. Effect of
polyamine depletion on caspase activation: a study with spermine
synthase-deficient cells. Biochemical Journal
355:199-206, 2001
- F. Flamigni, A. Facchini, I. Stanic, E. Giordano, B.
Tantini, C. Stefanelli. Control of
survival of proliferating L1210 cells by soluble guanylate
cyclase and p44/42 mitogen-activated protein kinase
modulators. Biochemical Pharmacology
62:319-328, 2001
- B. Tantini, F. Flamigni, C. Pignatti, C. Stefanelli, M.
Fattori, A. Facchini, E. Giordano, C. Clo, C.M.
Caldarera. Polyamines, nitric oxide and
cyclic GMP mediate stimulation of DNA synthesis by tumor
necrosis factor and lipopolysaccharide in chick embryo
cardiomyocytes. Cardiovascular Research
49:408-416, 2001
- F. Flamigni, A. Facchini, E. Giordano, B. Tantini, C.
Stefanelli. Signaling pathways leading to
the induction of ornithine decarboxylase: opposite effects of
p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK
inhibitors. Biochemical Pharmacology 61:25-32,
2001
- C. Stefanelli, I. Stanic, M. Zini, F. Bonavita, F.
Flamigni, L. Zambonin, L. Landi, C. Pignatti, C. Guarnieri, C.M.
Caldarera. Polyamines directly induce
release of cytochrome c from heart mitochondria.
Biochemical Journal 347:875-880, 2000
- C. Stefanelli, F. Bonavita, I. Stanic, C. Pignatti, F.
Flamigni, C. Guarnieri, C.M. Caldarera.
Spermine triggers the activation of caspase-3 in a cell-free model
of apoptosis. FEBS Letters 451:95-98,
1999
- C. Stefanelli, C. Pignatti, B. Tantini, I. Stanic, F.
Bonavita, C. Muscari, C. Guarnieri, C. Clo, C.M.
Caldarera. Nitric oxide can function as
either a killer molecule or an antiapoptotic effector in
cardiomyocytes. Biochimica et Biophysica Acta,
Mol.Cell.Res. 145:406-413, 1999
- F. Flamigni, A. Facchini, C. Capanni, C. Stefanelli, B.
Tantini, C.M. Caldarera. p44/42
mitogen-activated protein kinase is involved in the expression of
ornithine decarboxylase in leukaemia L1210 cells.
Biochemical Journal 341:363-369, 1999
- C. Pignatti, B. Tantini, C. Stefanelli, E. Giordano, F.
Bonavita, C. Clo, C.M. Caldarera.
Nitric oxide mediates either proliferation or cell death in
cardiomyocytes. Involvement of polyamines.
Amino Acids 16:181-190, 1999
- C. Stefanelli, C.M. Caldarera.
Meccanismi molecolari della morte cellulare
programmata. Cardiologia 43:135-140, 1998
- C. Stefanelli, F. Bonavita, I. Stanic, M. Mignani, A.
Facchini, C. Pignatti, F. Flamigni, C.M.
Caldarera. Spermine causes caspase
activation in leukaemia cells. FEBS Letters
437:233-236, 1998
- C. Stefanelli, F. Bonavita, I. Stanic, C.Pignatti, G.
Farruggia, L. Masotti, C. Guarnieri, C.M.
Caldarera. Inhibition of etoposide-induced
apoptosis with peptide aldehyde inhibitors of
proteasome. Biochemical Journal
332:661-665, 1998
- C. Pignatti, I. Stanic, C. Stefanelli, B. Tantini, C.
Rossoni, F. Flamigni. Modulation of
the induction of ornithine decarboxylase by some opioid receptor
agonist in immune cells and cardiomyocytes.
Molecular and Cellular Biochemistry 185:47-53,
1998
- C. Stefanelli, I. Stanic, F. Bonavita, F. Flamigni,
C.Pignatti, C. Guarnieri, C.M.
Caldarera. Inhibition of
glucocorticoid-induced apoptosis with
5-aminoimidazole-4-carboxamide-ribonucleoside, a cell-permeable
activator of AMP-activated protein kinase.
Biochemical and Biophysical Research Communications
243:821-82, 1998
- Flamigni F, Marmiroli S, Capanni C, Stefanelli C,
Guarnieri C, Caldarera CM.
Phosphatidylinositol 3-kinase is
required for the induction of ornithine decarboxylase in leukemia
cells stimulated to growth. Biochemical and
Biophysical Research Communications 239:729-733, 1997
- Flamigni F, Faenza I, Marmiroli S, Stanic' I, Giaccari
A, Muscari C, Stefanelli C, Rossoni C.
Inhibition of the expression of
ornithine decarboxylase and c-Myc by cell-permeant ceramide in
difluoromethylornithine-resistant leukaemia cells.
Biochemical Journal 324: 783-789, 1997
- Stefanelli C, Bonavita F, Stanic' I, Farruggia G,
Falcieri E, Robuffo I, Pignatti C, Muscari C, Rossoni C, Guarnieri
C, Caldarera CM. ATP depletion
inhibits glucocorticoid-induced thymocyte apoptosis. Biochemical
Journal 322: 909-917, 1997
- Muscari C, Giaccari A, Stefanelli C, Viticchi C,
Giordano E, Guarnieri C, Caldarera CM. Presence
of a DNA-4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse
cardiac mitochondrial DNA during aging. Aging
8:429-433, 1996
- Flamigni F, Stefanelli C, Stanic I, Muscari C, Giaccari
A, Rossoni C. Inhibition of the expression of ornithine
decarboxylase by some kappa-opioidergic 210 cells.
Biochimica et Biophysica
Acta 1311:204-210, 1996
- Muscari C, Guarnieri C, Stefanelli C, Giaccari A,
Caldarera CM. Protective effect of spermine on
DNA exposed to oxidative stress. Molecular and Cellular
Biochemistry 144:15-129, 1995
- Muscari C, Biagetti L, Stefanelli C, Giordano E,
Guarnieri C, Caldarera CM. Adaptive changes
in coenzyme Q biosynthesis to myocardial reperfusion in young and
aged rats. Journal of Molecular and Cellular
Cardiology 27:283-291, 1995
- Stefanelli C, Stanic I, Bonavita F, Muscari C, Pignatti
C, Rossoni C, Caldarera CM. Oxygen tension
influences DNA fragmentation and cell death in
glucocorticoid-treated
thymocytes. Biochemical and
Biophysical Research Communications 212:300-306,1995
