Introduction: Phosphatidylinositols (PIs) are responsible for several signaling pathways related to many cellular functions, such as cell cycle regulation at different checkpoints, cell proliferation, cell differentiation, membrane trafficking and gene expression. PI metabolism is not only present at the cytoplasmic level, but also at the nuclear one, where different signaling pathways affect essential nuclear mechanisms in eukaryotic cells. Many evidences underline the pivotal role of nuclear inositide signaling in different strategic physiopathological mechanisms in several cell systems and diseases.
Aims: our aim is to study the many mechanisms of PIs in different systems and diseases such as myelodysplatic syndrome (MDS), glioblastoma (GBM), autosomal dominant leukodystrophy with autonomic disease (ADLD) and Cardiac amyloidosis. Especially in MDS we investigated the relationship between phospholipase C and PI3K/Akt. The understanding of different pivotal mechanisms could open new possibilities of research and of individualized therapies.
