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Patrizia Hrelia

Professoressa ordinaria

Dipartimento di Farmacia e Biotecnologie

Settore scientifico disciplinare: BIO/14 FARMACOLOGIA

Coordinatrice del Corso di Laurea Magistrale a ciclo unico in Farmacia


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Pubblicazioni antecedenti il 2004

Pubblicazioni 1984-2003


1.       CANTELLI FORTI G., M.E. FRACASSO, P. HRELIA, R. LEONE, M.S. VENTURINI, M.C. GUERRA 1984. Metabolic activation of 2-aminofluorene in the Salmonella mutagenicity assay by different S-9 preparations. Arch. Toxicol. suppl. 7, 243-248.

2.      CHIECO P., P. HRELIA, S. CANDELETTI, S. FERRI, G. CANTELLI FORTI 1984. Methadone affects the histochemical pattern of xenobiotic-metabolizing enzymes in liver of pregnant rats. Arch. Toxicol. suppl. 7, 261-265.

3.        CANTELLI FORTI G., M. PAOLINI, P. HRELIA, C. CORSI, G.L. BIAGI, G. BRONZETTI 1984. NADPH-generating system: influences on microsomal mono-oxygenase stability during incubations for the liver microsomal assay with rat and mice S-9 fraction. Mutat. Res. 129, 291-297.

4.        PAOLINI M., C. BAUER, C. CORSI, F. TONELLI, P. HRELIA, G. BRONZETTI, G. CANTELLI FORTI 1984. Effect of repeated anesthesias on the mono-oxygenase system of rat liver S-9 fraction. Teratogen. Carcin. Mut. 4, 477-481.

5.        CANTELLI FORTI G., P. HRELIA, M. PAOLINI, G. BRONZETTI, G.L. BIAGI 1985. The organospecific activity of metronidazole and azanidazole in the intrasanguineous host-mediated assay. Drugs Exp. Clin. Res. 11 (11), 755-759.

6.        CANTELLI FORTI G., M.C. GUERRA, A.M. BARBARO, P. HRELIA, G.L. BIAGI, P.A. BOREA 1986. Relationship between lipophilic character and urinary excretion of 24 nitroimidazoles and 2 nitrothiazoles. J. Med. Chem. 29, 555-561.

7.        CANTELLI FORTI G., M. PAOLINI, P. HRELIA, C. CORSI, G. BRONZETTI 1986. Genetic activity of 2-aminofluorene in the Salmonella/erythrocyte mutagenicity assay. Mutat. Res. 174, 169- 173.

8.        BIAGI G.L., P. HRELIA, M.C. GUERRA, M. PAOLINI, A.M. BARBARO, G. CANTELLI FORTI 1986. Structure-activity relationship of nitroimidazo(2,1-b)thiazoles in the Salmonella mutagenicity assay. Arch. Toxicol. suppl. 9, 425-429.

9.        HRELIA P.,  M. PAOLINI, G.L. BIAGI, G. CANTELLI FORTI 1986. The direct acting mutagenicity of nitroimidazo(2,1-b)thiazoles in Salmonella typhimurium. Teratogen. Carcin. Mut. 6, 511-519.

10.     BIAGI G.L., G. CANTELLI FORTI, A.M. BARBARO, M.C. GUERRA, P. HRELIA, P.A. BOREA 1987. The influence of physico chemical parameters on the biliary excretion of a serie of nitroimidazoles. J. Med. Chem. 30, 420-423.

11.     PAOLINI M.,  P. HRELIA, C. CORSI, G. BRONZETTI, G.L. BIAGI, G. CANTELLI FORTI 1987. NADPH as a rate limiting factor for microsomal metabolism. An alternative and economic NADPH- generating system for  microsomal  mono-oxygenase in vivo genotoxicity studies. Mutat. Res. 178, 11-20.

12.     CANTELLI FORTI G., M. PAOLINI, P. HRELIA, E. SAPIGNI, G.L. BIAGI 1987. Effects of metronidazole, azanidazole and azathioprine on cytochrome P-450 and various mono-oxygenase activities in hepatic microsomes from control and induced mice. Arch. Toxicol. suppl. 11, 264-269.

13.     HRELIA P., L. MURELLI, M. PAOLINI, G. CANTELLI FORTI 1987. In vivo protective role of antioxidants against genotoxicity of metronidazole and azanidazole. Drugs Exptl. Clin. Res. 13, 577- 583.

14.     HRELIA P., L. MURELLI, M. PAOLINI, E. SAPIGNI, G. CANTELLI FORTI 1987. Inducibility of NADPH cytochrome c (P-450) reductase in yeast: role in the bioactivation of nitroimidazo(2,1- b)thiazoles. Mutagenesis 2 (6), 425-429.

15.     CANTELLI FORTI G., P. HRELIA, M. SCOTTI, V. SCORNAVACCHE, M. PRADA 1987. Mutagenicity studies on thymomodulin, Arzneim./Helforschung. 37 (11), 1269-1273.

16.     PAOLINI M., E. SAPIGNI, P. HRELIA, S. GRILLI, G. CANTELLI FORTI 1988. Isolation of S9 fractions from mouse and rat with increased enzyme activities after repeated administration of cytochrome P-450 and P-448 inducers. Mutagenesis 3, 239-243.

17.     HRELIA P., L. MURELLI, M. SCOTTI, M. PAOLINI, G. CANTELLI FORTI 1988. Organospecific activation of azathioprine in mice: role of liver metabolism in mutation induction. Carcinogenesis 9, (6), 1011-1015.

18.     CHIECO P., P. HRELIA, G. LISIGNOLI, G. CANTELLI FORTI 1988. Quantitative enzyme histochemistry of rat fetal brain and trigeminal ganglion. Histochem. J. 20, 455-463.

19.     PAOLINI M.,  E. SAPIGNI, P. HRELIA, S. GRILLI, G. LATTANZI, G. CANTELLI FORTI 1988. Improvement of short-term test for mutagenicity on the optimal pH for the liver microsomal assay. Carcinogenesis 9 (12), 2265-2270.

20.     CANTELLI FORTI G., M.C. GUERRA, M. SCOTTI, P. HRELIA, M. PAOLINI, G.L. BIAGI 1989. Biliary excretion of mutagenic forms of nitroimidazoles in rats. Arch. Toxicol. suppl. 13, 333-339.

21.     PAOLINI M., E. SAPIGNI, P. HRELIA, G. CANTELLI FORTI 1989. The synergistic effect of NADPH and NADH on P450 function in process premutagens. Pharmacol. Res. 21 (suppl. 1), 129-130.

22.           PAOLINI M.,  E. SAPIGNI, P. HRELIA, S. GRILLI, G. LATTANZI, M. SCOTTI, G. CANTELLI FORTI 1990. Strategies for the optimization of short-term genotoxicity tests: the synergistic effect of NADPH and NADH on P 450 function in processing premutagens. Mutagenesis 5, 51-54.

23.     HSIE A.W., Z. XU, Y. YU, M.A. SOGNIER, P. HRELIA 1990. Molecular analysis of reactive oxygen-species-induced mammalian gene mutation. Teratogen. Carcin. Mut. 10, 115-124.

24.     AU W.W., G. CANTELLI FORTI, P. HRELIA, M.S. LEGATOR 1990. Cytogenetic assays in genotoxic studies: somatic cell effects of benzene and germinal cell effects of dibromochloropropane. Teratogen. Carcin. Mut. 10, 125-134

25.     HRELIA P., M. SCOTTI, M. MOROTTI, F. VIGAGNI, M. PAOLINI, S. SAPIGNI, G. CANTELLI FORTI 1990. Dimethylsulfoxide as modifies of the organospecific mutagenicity of metronidazole in mice. Teratogen. Carcin. Mut. 10, 263-271.

26.     HRELIA P., M. MOROTTI, M. SCOTTI, F. VIGAGNI, M. PAOLINI, P. PEROCCO, G. CANTELLI FORTI 1990. Genotoxic risk associated with pesticides: evidences on short-term tests. Pharmacol. Res. 22 (suppl. 3), 93-94.

27.     RODA A., P. HRELIA, M. PAOLINI, M. CALZOLARI, B. GRIGOLO, P. SIMONI, R. ALDINI, G. CANTELLI FORTI 1991. Pharmacokinetics of ursodeoxycholic acid in rat. Pharmacol. Res. 23 (4), 327-335.

28.     PAOLINI M., E. SAPIGNI, P. HRELIA, M. SCOTTI, M. MOROTTI, G. CANTELLI FORTI 1991. Wide spectrum detection of precarcinogens in short-term bioassays by simultaneous induction of multiforms of cytochrome P450 isoenzymes. Carcinogenesis 12, 759-766.

29.     CANTELLI FORTI G., P. HRELIA 1991. Potential genotoxic risk of antimicrobial agents. G. Ital. Chemioter. 38 (1-3), 31-34.

30.     SAPIGNI E., M. PAOLINI, R. MESIRCA, P. HRELIA, P. RONCADA, G. CANTELLI FORTI 1992. Short-chain aliphatic halocompounds: "in vivo" effects on microsomal monooxygenase (P450-dependent) system. Pharmacol. Res. 25 (suppl. 1), 77-78.

31.     HRELIA P., F. VIGAGNI, M. MOROTTI, G. CANTELLI FORTI, C.L. BARBIERI, D. SPINELLI, L. LAMARTINA 1993. Mechanism of genotoxicity and electron density distribution by NMR of 5-nitro-3-thiophenecarboxamides, a novel group of direct-acting mutagens in Salmonella typhimurium. Chem.-Biol. Interact. 86, 229-254.

32.     HRELIA P., M. MOROTTI, F. VIGAGNI, S. BURNELLI, L. GARUTI, P. SABATINO, G. CANTELLI FORTI 1993. Synthesis of a series of 5-nitro-(benzimidazoles and indoles) as novel antimycotics and evaluation as genotoxins in the Ames test. Mutagenesis 8, 183-188.

33.     CANTELLI FORTI G., M. PAOLINI, P. HRELIA 1993. Multi-endpoint procedure to evaluate risk from pesticides. Environm. Health Perspect. 101 (suppl. 3), 15-20.

34.     HSIE A.W., Z. XU, Y. YU, J. AN, M.L. MELTZ, J.L. SCHWARTZ, P. HRELIA 1993. Quantitative and molecular analysis of genetic risk: a study with ionizing radiations. Environm. Health Perspect. 101 (suppl. 3), 213-218.

35.     HRELIA P., M. MOROTTI, F. VIGAGNI, F. MAFFEI, M. PAOLINI, G. CANTELLI FORTI 1993. Murine alpha/beta interferons inhibit benzo(a)pyrene activation and mutagenesis mice. Basic Life Sci. 61, 325-334.

36.     HRELIA P., F. VIGAGNI, F. MAFFEI, G. CANTELLI FORTI 1993. The involvement of reactive oxygen species in the direct-acting mutagenic 5-nitro-3-thiophenecarboxanilides in Salmonella typhimurium. J. Environ. Pathol. Toxicol. Oncol. 12 (4), 185-191.

37.     HRELIA P., M. MOROTTI, F. VIGAGNI, F. MAFFEI, M. PAOLINI, R. MESIRCA, G. CANTELLI FORTI 1994. The modulating activity of interferon on benzo(a)pyrene bioactivation and clastogenesis in mice. Pharmacol. Toxicol. 74, 249-254.

38.     HRELIA P., F. VIGAGNI, F. MAFFEI, M. MOROTTI, A. COLACCI, P. PEROCCO, S. GRILLI, G. CANTELLI FORTI 1994. Genetic safety evaluation of pesticides in a battery of short-term test. Mutat. Res. 321, 219-228.

39.     HRELIA P., F. VIGAGNI, F. MAFFEI, M. PAOLINI, R. MESIRCA, L. POZZETTI, G. CANTELLI FORTI 1994. A battery of biomarkers for detecting carcinogenic risk from fungicides. Clin. Chem. 40, 1460-1462.

40.     HRELIA P., F. MAFFEI, F. VIGAGNI, C. FIMOGNARI; P. FLORI, R. STANZANI, G. CANTELLI FORTI 1994. Interactive effects between trichloroethylene and pesticides at metabolic and genetic level in mice. Environ. Health Persp. 102 (suppl. 9), 31-34.

41.     CANTELLI FORTI G., F. MAFFEI, P. HRELIA, F. BUGAMELLI, M. BERNARDI, P. D'INTINO, M. MARANESI, M.A. RAGGI 1994. Interaction of licorice on glycyrrhizin pharmacokinetics. Environ. Health Persp. 102 (suppl. 9), 65-68.

42.     HRELIA P., F. VIGAGNI, F. MAFFEI, C. FIMOGNARI, L. LAMARTINA, D. SPINELLI, P. JURIC, M.C. GUERRA, G. CANTELLI FORTI 1995. Analysis of metabolism and genotoxicity of 5-nitro-3-thiophenecarboxanilides in bacterial, mammalian and human cells. Mutagenesis 10, 171-177.

43.     VIGAGNI F., P. HRELIA, G. CANTELLI FORTI, M. SORSA, H. NORPPA 1995. An improved assay to detect 6-thioguanine resistant mutants in human lymphocytes. Exp. Clin. Cancer Res 14 (suppl.), 171-173.

44.     TANNEBERGER S., P. HRELIA 1996. Interferons in precancer and cancer prevention: where are we? J. Interf. Cytok. Res. 16, 339-346.

45.     PAOLINI M., R. MESIRCA, L. POZZETTI, F. MAFFEI, F. VIGAGNI, P. HRELIA, G. CANTELLI FORTI 1996. Genetic and non-genetic biomarkers related to carcinogenesis in evaluating risk from Fenarimol. Mutat. Res. 368, 27-39.

46.     HRELIA P., C. FIMOGNARI, F. MAFFEI, F. VIGAGNI, R. MESIRCA, L. POZZETTI, M. PAOLINI, G. CANTELLI FORTI 1996. The genetic and non-genetic toxicity of the fungicide Vincolozolin. Mutagenesis 11, 445-453.

47.     HRELIA P., F. MAFFEI, C. FIMOGNARI, F. VIGAGNI, G. CANTELLI FORTI 1996. Cytogenetic effects of Metalaxyl on human and animal chromosomes. Mutat. Res. 369, 81-86.

48.     HRELIA P., C. FIMOGNARI, F. VIGAGNI, F. MAFFEI, G. CANTELLI FORTI 1996. A cytogenetic approach to the study of genotoxic effects of fungicides: an in vitro study in lymphocyte cultures with thiophanate-methyl. ATLA 24, 597-601.

49.     HRELIA P., C. FIMOGNARI, F. MAFFEI, F. VIGAGNI, G. CANTELLI FORTI 1996. Potential antimutagenic activity of Glycyrrhiza Glabra extract. Phytother Res. 10, S101-S103.

50.     HRELIA P., S. TANNEBERGER 1997. Immunoprevention of cancer poses a challenge to pharmacological research. Pharmacol. Res. 35, 391-401.

51.     HRELIA P., C. FIMOGNARI, F. MAFFEI, B. BRIGHENTI, L. GARUTI, S. BURNELLI, G. CANTELLI FORTI 1998. Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium. Mutat. Res. 397, 293-301.

52.     CANTELLI FORTI G., P. HRELIA, M. PAOLINI 1998. The pitfall of detoxifying enzymes. Mutat. Res. 402, 179-183.

53.     FIMOGNARI C., M. NÜSSE, P. HRELIA 1999. Flow cytometric analysis of genetic damage, effect on cell cycle progression, and apoptosis by Thiophanate-Methyl in human lymphocytes. Environ. Mol. Mutagen. 33, 173-176.

54.     HRELIA P., C. FIMOGNARI, F. MAFFEI, D. SPINELLI, L. LAMARTINA, M.C. SARVÀ, G. CANTELLI FORTI 1999. Influence of nitroreductase and O-acetyltransferase on the mutagenicity of substituted nitrobenzothiophenammines in Salmonella typhimurium. Chem.-Biol. Interact. 118, 99-111.

55.     CASTELLI E., P. HRELIA, F. MAFFEI, C. FIMOGNARI, F.G. FOSCHI, F. CAPUTO, G. CANTELLI FORTI, G.F. STEFANINI, G. GASBARRINI 1999. Indicators of genetic damage in alcoholics: reversibility after alcohol abstinence. Hepato-Gastroenterol. 46, 1664-1668.

56.     MAFFEI F., F. VIGAGNI, H. NORPPA, P. HRELIA 1999. Bromodeoxyuridine labelling as an alternative method to identify 6-thioguanine resistant mutant lymphocytes in humans. Mutat. Res. 431, 223-231.

57.     FIMOGNARI C., M. NÜSSE, G. CANTELLI FORTI, P. HRELIA 2000. New in vitro approaches to explore cellular and molecular events related to carcinogenesis. Pharmacol. Res. 41(4), 385-390.

58.     DAMIANI E., L. GRECI, P. HRELIA 2000. Cyto- and genotoxic effects of novel aromatic nitroxide radicals in vitro. Free Radic. Bio. Med. 28(3), 330-336.

59.     MAFFEI F., C. FIMOGNARI, E. CASTELLI, G.F. STEFANINI, G. CANTELLI FORTI, P. HRELIA 2000. Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics. Mutagenesis 15, 517-523.

60.     BONASSI S., M. FENECH, C. LANDO, P. HRELIA and other 29 authors 2001. HUman MicroNucleous Project: International database comparison for results with the cytokinesis-block micronucleous assay in human lymphocytes. I-Effect of laboratory protocol, scoring criteria and host factors on the frequency of micronuclei. Environ. Mol. Mutagen. 37 (1), 31-45.

61.     ANDRISANO V., R. BALLARDINI, P. HRELIA, N. CAMELI, A. TOSTI, R. GOTTI, V. CAVRINI 2001. Studies on the photostability and in vitro phototoxicity of Labetalol. Eur. J. Pharm. Sci. 12, 495-504.

62.     ANDRISANO V., P. HRELIA, R. GOTTI, A. LEONI, V. CAVRINI 2001. Photostability and phototoxicity studies on Diltiazem. J. Pharm. Biomed. Anal. 25, 589-597.

63.     FIMOGNARI C., M. NÜSSE, R. CESARI, G. CANTELLI FORTI, P. HRELIA 2001. Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. Mutation Res. 495, 1-9.

64.     HRELIA P., C. FIMOGNARI, F. MAFFEI, G. BRANDI, G. BIASCO, G. CANTELLI FORTI 2002. Mutagenic and clastogenic activity of gastric juice in human gastric diseases. Mutation Res. 514, 125-132.

65.     MAFFEI F., G. CANTELLI FORTI, E. CASTELLI, G.F. STEFANINI, S. MATTIOLI, P. HRELIA 2002. Biomarkers to assess the genetic damage induced by alcohol abuse in human lymphocytes. Mutation Res. 514, 49-58.

66.     FIMOGNARI C., M. NÜSSE, R. CESARI, R. IORI, G. CANTELLI FORTI, P. HRELIA 2002. Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis 23 (4), 581-586.

67.     MAFFEI F., S. ANGELINI, G. CANTELLI FORTI, V. LODI, F.S. VIOLANTE, S. MATTIOLI, P. HRELIA 2002. Micronuclei frequencies in hospital workers occupationally exposed to levels of ionizing radiation: influence of smoking status and other factors. Mutagenesis 17 (5), 405-409.

68.     FIMOGNARI C., M. NÜSSE, F. BERTI, R. IORI, G. CANTELLI FORTI, P. HRELIA 2002. Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes. Cell. Mol. Life Sci. 59 (11), 2004-2012.

69.     FENECH M., S. BONASSI, J. TURNER, P. HRELIA and other 34 authors 2003. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutation Res. 534 (1-2), 45-64.

70.     BONASSI S., M. NERI, C. LANDO, M. CEPPI, Y. LIN, W.P. CHANG, N. HOLLAND, M. KIRSCH-VOLDERS, E. ZEIGER, M. FENECH and the HUMN collaborative group 2003. Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus Project. Mutation Res. 543, 155-166.

71.     HRELIA P., A. TAROZZI, G. CANTELLI FORTI 2003. Diet and risk of cancer. Lancet 361 (9353), 258.

72.     VIOLANTE F.S., G. SANGUINETTI, A. BARBIERI, A. ACCORSI, S. MATTIOLI, R. CESARI, C. FIMOGNARI, P. HRELIA 2003. Lack of correlation between environmental or biological indicators of benzene exposure at parts per billion levels and micronuclei induction. Environ. Res. 91 (3), 135-142.

73.     TAROZZI A., V. ANDRISANO, J. FIORI, V. CAVRINI, G. CANTELLI FORTI, P. HRELIA 2003. Photomutagenic properties of terfenadine as revealed by a stepwise photostability, phototoxicity and photomugenicity testing approach. Photochem. Photobiol. 77 (4), 356-361.

74.     HRELIA P., F. MAFFEI, S. ANGELINI, G. CANTELLI FORTI 2003. Biomarcatori di effetto e suscettibilità per la valutazione del rischio. G. It. Med. Lav. Erg. 25, 342-343.

75.     TAROZZI A., P. HRELIA 2003. Mele da produzione biologica e da produzione integrata. Attività antiossidante a confronto. ARS 90, 45-48.

76.     FIORI J., R. BALLARDINI, P. HRELIA, V. ANDRISANO, A. TAROZZI, V. CAVRINI 2003. Investigation of the photochemical properties and in vitro phototoxic potential of bumetamide. Photochem. Photobiol Sci. 2 (10), 1011-1017.

77.     FIMOGNARI C., M. NÜSSE, F. BERTI, R. IORI, G. CANTELLI FORTI, P. HRELIA 2003. Sulforaphane modulates cell cycle and apoptosis in transformed and non transformed human T lymphocytes. Ann. N.Y. Acad. Sci. 1010, 393-398.

78.     HRELIA P., C. FIMOGNARI, G. CANTELLI FORTI 2003. Glucosinolates in cancer prevention. Agroindustria 2, 65-67.