Foto del docente

Paolo Emidio Costantini

Assegnista di ricerca

Dipartimento di Farmacia e Biotecnologie

Tutor didattico

Dipartimento di Farmacia e Biotecnologie

Curriculum vitae

 EDUCATION

PhD in Cellular and Molecular Biology, University of Bologna (2017 - 2020)

Thesis title: Genomic and functional insights into the interactions between Lactobacillus strains and pathogens

Supervisors: Dr. Cappelletti M, Prof. Vitali B, Dr. Ñahui Palomino RA

Master degree in Molecular and Industrial Biotechnology, University of Bologna (2013 - 2016)

Thesis title: Functional genomics of NikR in Helicobacter pylori

Supervisors: Prof. Danielli A, Dr. Vannini A

Bachelor degree in Biological Science, University of Bologna (2010 - 2013)

Thesis title: Studio della struttura del biofilm di Pleurotus ostreatus 3003 mediante CLSM e analisi dell'assorbimento di Cr(VI) da parte di biofilm monospecifici di P. ostreatus e Pseudomonas alcaliphila B4

Supervisor: Dr. Fedi S

RESEARCH EXPERIENCE

Post-doc in Molecular Microbiology (11/2020 – Today)

University of Bologna, Italy (Supervisor: Prof. Danielli A)

Application of filamentous phage as targeting vector against microbial pathogens and tumors in sonodynamic, photodynamic and photothermal therapies.

Visiting Research Fellow (1/2020 – 7/2020)

National Institute of Health - NIH, USA (Supervisors: Dr. Margolis L, Dr. Ñahui Palomino RA)

Investigation of anti-HIV-1 activity exerted by bacterial extracellular vesicles.

PhD in Cellular and Molecular Biology (11/2017 – 10/2020)

University of Bologna, Italy (Supervisors: Dr. Cappelletti M, Prof. Vitali B)

Application and characterization of Lactobacillus strains with antimicrobial activity.

USSHER Fellowship (09/2016 – 03/2017)

Trinity College of Dublin, Ireland (Supervisor: Prof. Dorman CJ)

Study of SPI-1 and SPI-2 chromosome locations in Salmonella Typhimurium.

Post master degree internship (03/2016 – 07/2016)

University of Bologna, Italy (Supervisor: Prof. Danielli A)

Study of the transcriptional regulator Fur (Ferric Uptake Regulator) in Helicobacter pylori.

Master degree internship (03/2015 – 02/2016)

University of Bologna, Italy (Supervisors: Prof. Danielli A, Dr. Vannini A)

Re-definition of the NikR (nickel dependent transcriptional regulator) regulon in Helicobacter pylori through the integration of different genome-wide strategies (ChIP-seq and RNA-seq) and molecular biology techniques.

Bachelor degree internship (03/2013 – 10/2013)

University of Bologna, Italy (Supervisors: Dr. Fedi S, Prof. Zannoni D)

Study of bacterial and fungal biofilms and their abilities to reduce and absorb hexavalent-chrome (CrVI).

PUBLICATIONS

Giordani B & Costantini PE, Fedi S, Cappelletti M, Abruzzo A, Parolin C, Foschi C, Frisco G, Calonghi N, Cerchiara T, Bigucci F, Luppi B, Vitali B. "Liposomes containing biosurfactants isolated from Lactobacillus gasseri exert antibiofilm activity against methicillin resistant Staphylococcus aureus strains." European Journal of Pharmaceutics and Biopharmaceutics (2019)https://doi.org/10.1016/j.ejpb.2019.04.011

Vannini A & Pinatel E, Costantini PE, Pelliciari S, Roncarati D, Puccio S, De Bellis G, Peano C and Danielli A. “Comprehensive mapping of the Helicobacter pylori NikR regulon provides new insights in bacterial nickel responses”. Sci. Rep. 7, 45458; doi: 10.1038/srep45458 (2017)

TEACHING EXPERIENCE

Co-supervisor of 6 BSc thesis in Microbiology and Molecular Biology.

Teaching tutor in Industrial Biochemistry (2020), Microbial biotechnology (2019) and Molecular Biology (2018) for the MSc in molecular and industrial biotechnology, University of Bologna

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