FORMAZIONE
Laurea triennale in Scienze Biologiche (2015) presso Università degli Studi di Siena e Laurea Magistrale in Biologia Molecolare e Cellulare (2018) presso Alma Mater Studiorum - Università di Bologna.
Dottorato di ricerca in Oncologia, Ematologia e Patologia - 35° ciclo
ATTIVITA' DIDATTICA
Docente a contratto per il corso "Histology Laboratory – sdoppiamento G6” in lingua inglese, facente parte del corso integrato “Morphology and development” - Corso di Laurea Magistrale a Ciclo Unico in Medicine and Surgery, Alma mater studiorum – Università di Bologna (A.A. 2025/2026)
Tutor didattico per il corso "Histology Laboratory" C.I. Morphology and Development (CdS Medicine and Surgery, Università di Bologna) dall'anno accademico 2017/2018 all'anno accademico 2025/2026
Tutor didattico per il corso "Laboratorio di Istologia ed Embriologia" C.I. Istologia ed Embriologia (CdS Medicina e Chirurgia, Università di Bologna) nell'anno accademico 2022/2023
PUBBLICAZIONI
A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers
Guerra AD, Matkar S, Acholla C, Casey C, Li G, Mazzeschi M, Patel K, Krytska K, Chen C, Balyasny S, Kalna J, Kamitsuka P, Gerelus M, Polkosnik G, Groff D, Mukherje A, Adams C, Witek G, Hamilton AK, Martinez D, Pogoriler J, Spear TT, Li Y, Jung P, Alvarado D, Lauriola M, Maris JM, Wolpaw AJ, Bosse KR, Dimitrov D, Mir M, Jelev DV, Mossé YP
Nature Communications, 2025 August 15
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies
Romaniello D, Dall’Olio L, Mazzeschi M, Francia A, Pagano F, Gelfo V, D’Uva G, Giampieri E, Lauriola M
SLAS Discovery, 2025 January 31
Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unknown primary
Cavazzoni A, Salamon I, Fumarola C, Gallerani G, Laprovitera N, Gelsomino F, Riefolo M, Rihawi K, Porcellini E, Rossi T, Mazzeschi M, Naddeo M, Serravalle S, Broseghini E, Agostinis F, Deas O, Roncarati R, Durante G, Pace I, Lauriola M, Garajova I, Calin GA, Bonafè M, D’Errico A, Petronini PG, Cairo S, Ardizzoni A, Sales G, Ferracin M
Molecular Therapy, 2024 July 17
BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
Bongiovanni C, Bueno-Levy H, Posadas Pena D, Del Bono I, Miano C, Boriati S, Da Pra S, Sacchi F, Redaelli S, Bergen M, Romaniello D, Pontis F, Tassinari R, Kellerer L, Petraroia I, Mazzeschi M, Lauriola M, Ventura C, Heermann S, Weidinger G, Tzahor E, D’Uva G
Cell Reports, 2024 May 28
Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation
Sgarzi M*, Mazzeschi M*, Santi S, Montacci E, Panciera T, Ferlizza E, Girone C, Morselli A, Gelfo V, Kuhre RS, Cavallo C, Valente S, Pasquinelli G, Győrffy B, D’Uva G, Romaniello D and Lauriola M
*Co-first authors
Communications Biology, 2023 October 14
Extracellular vesicles and Epidermal Growth Factor Receptor activation: interplay of drivers in cancer progression
Ferlizza E, Romaniello D, Borrelli F, Pagano F, Girone C, Gelfo V, Kuhre RS, Morselli A, Mazzeschi M, Sgarzi M, Filippini DM, D’Uva G and Lauriola M
Cancers, 2023 May 30
Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration
Pianca N, Sacchi F, Umansky KB, Chirivì M, Iommarini L, Da Pra S, Papa V, Bongiovanni C, Miano C, Pontis F, Braga L, Tassinari R, Pantano E, Patnala RS, Mazzeschi M, Cenacchi G, Porcelli AM, Lauriola M, Ventura C, Giacca M, Rizzi R, Tzahor E and D’Uva G
Nature Cardiovascular Research, 2022 June 23
Neuregulin 4 boosts the efficacy of anti-ERBB2 neutralizing antibodies
Miano C, Romaniello D, Mazzeschi M, Morselli A, Da Pra S, Sacchi F, Bongiovanni C, Sgarzi M, Pantano E, Lauriola M, D’Uva G
Frontiers in Oncology, 2022 May 18
The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer
Mazzeschi M, Sgarzi M, Romaniello D, Gelfo V, Cavallo C, Ambrosi F, Morselli A, Miano C, Laprovitera N, Girone C, Ferracin M, Santi S, Rihawi K, Ardizzoni A, Fiorentino M, D’Uva G, Győrffy B, Palmer R, Lauriola M
Journal of Experimental & Clinical Cancer Research, 2022 March 29
Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization
Romaniello D, Gelfo V, Pagano F, Ferlizza E, Sgarzi M, Mazzeschi M, Morselli A, Miano C, D’Uva G, Lauriola M
Cellular & Molecular Biology Letters, 2022 March 02
Fibroblast-associated protein-α expression and BPV nucleic acid distribution in equine sarcoids
Tura G, Savini F, Gallina L, La Ragione RM, Durham AE, Mazzeschi M, Lauriola M, Avallone G, Sarli G, Brunetti B, Muscatello LV, Girone C, Bacci B
Veterinary Pathology, 2021 June 15
A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib
Sargenti A, Musmeci F, Cavallo C, Mazzeschi M, Bonetti S, Pasqua S, Bacchi F, Filardo G, Gazzola D, Lauriola M, Santi S
PLoS ONE, 2021 June 08
Pharmacological inhibition of the ALK axis elicits therapeutic potential in Consensus Molecular Subtype 1 colon cancer patients
Mazzeschi M, Sgarzi M, Romaniello D, Gelfo V, Cavallo C, Santi S, Fiorentino M, D’Uva G, Győrffy B, Palmer R and Lauriola M
bioRxiv (preprint), 2020 October 08
Roles of IL-1 in Cancer: From Tumor Preogression to Resistance to Targeted Therapies
Gelfo V, Romaniello D, Mazzeschi M, Sgarzi M, Grilli G, Morselli A, Manzan B, Rihawi K, Lauriola M
International Journal of Molecular Sciences (Impact Factor 4.556), 2020 August 20, 21(17), 6009
Glucocorticoid Receptor ablation promotes cardiac regeneration by hampering cardiomyocyte terminal differentiation
Pianca N, Pontis F, Chirivì M, Papa V, Braga L, Patnala RS, Bongiovanni C, Mazzeschi M, Umansky KB, Cenacchi G, Lauriola M, Giacca M, Rizzi R, Tzahor E, D’Uva G
bioRxiv (preprint), 2020 January 15
Glucocorticoid Receptor Modulates EGFR Feedback upon Acquisition of Resistance to Monoclonal Antibodies
Gelfo V, Pontis F, Mazzeschi M, Sgarzi M, Mazzarini M, Solmi R, D’Uva G and Lauriola M.
Journal of Clinical Medicine (Impact Factor 5.688), 2019 May 1, 8(5), 600
A Novel Role for the Interleukin-1 Receptor Axis in Resistance to Anti-EGFR Therapy
Gelfo V*, Mazzeschi M*, Grilli G, Lindzen M, Santi S, D'Uva G, Győrffy B, Ardizzoni A, Yarden Y, Lauriola M.
*Co-first authors
Cancers (Impact Factor 6.162), 2018 September 26, 10(10), 355
