In our lab, we explore the dynamic roles of CoREST complexes, traditionally known as transcriptional repressors.
Our recent findings reveal that one of these complexes, driven by RCOR2, can activate transcription despite containing classical repressive enzymes like LSD1 and HDAC1/2.
We're on a mission to uncover the mechanism behind this surprising switch and to investigate a novel, potentially therapeutic axis linking RCOR2 and the oncogene MYCN.
We work primarily with human neuroblastoma cell lines, applying a range of cutting-edge molecular biology techniques, including ChIP/RNA-seq, RT-qPCR, gel filtration chromatography, Western blotting, plasmid cloning, and CRISPR-based KO/KI genetic screening.
