The Metabolic Genesis of Cardiovascular Disease
A special issue of [https://www.mdpi.com/journal/metabolites] (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research [https://www.mdpi.com/journal/metabolites/sections/endocrinology-clinical-metabolic-research] ".
Deadline for manuscript submissions: 30 April 2026
Special Issue Information
Dear Colleagues,
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, exerting a significant burden on public health systems and economies. In parallel, the world is facing an unprecedented epidemic of metabolic disorders—including obesity, insulin resistance, type 2 diabetes, and dyslipidemia—which are emerging at alarming rates, particularly among younger populations. A key driver of this trend is an increasing dietary imbalance characterized by excessive consumption of carbohydrates and simple sugars, leading to chronic overstimulation of the insulin axis. This hyperinsulinemic state contributes to systemic inflammation, endothelial dysfunction, and metabolic disturbances that collectively accelerate cardiovascular damage.
Increasing evidence implicates metabolic dysfunction as a central driver of chronic low-grade inflammation and immune dysregulation, both of which play pivotal roles in the pathogenesis and progression of CVD. A growing body of research has unveiled intricate links between metabolic derangements and cardiovascular risk, revealing how alterations in metabolites, metabolic pathways, and signaling networks contribute directly to vascular injury, atherosclerosis, and cardiac dysfunction.
This Special Issue, “The Metabolic Genesis of Cardiovascular Disease”, focuses on exploring the emerging concept that metabolic disorders are not merely risk factors but may represent fundamental causative events in cardiovascular disease. We welcome contributions that provide novel insights into dietary influences, metabolomic profiles, inflammatory pathways, immune system interactions, and metabolic networks involved in cardiovascular pathology, as well as studies proposing innovative strategies for early detection, prevention, and treatment of metabolic-driven cardiovascular diseases.
Dr. Davide Agnoletti
Guest Editor
https://www.mdpi.com/journal/metabolites/special_issues/98HNYGB9G8
Pubblicato il: 18 agosto 2025
