Foto del docente

Daniela Platano

Professoressa a contratto

Dipartimento di Scienze Biomediche e Neuromotorie

Curriculum vitae

FORMAZIONE

2019 - Specializzazione in Medicina Fisica e Riabilitativa con lode, presso Alma Mater Studiorum Università di Bologna

2012 - Laurea Medicina e Chirurgia con lode, presso Alma Mater Studiorum Università di Bologna 

2005 - Dottore di Ricerca in Neurofisiologia presso Università di Bologna

1994 - Laurea in Chimica e Tecnologia Farmaceutiche con lode, presso l'Università degli Studi di Torino

 

ATTIVITA' di RICERCA

Dal 01/08/2012 al 31/07/2013 Assegnista di Ricerca presso Alma Mater Studiorum Università di Bologna - DIPARTIMENTO DI MEDICINA CLINICA

Dal 16/10/2009 al 31/07/2012 Collaboratore alla ricerca presso Istituto Ortopedico Rizzoli, Bologna. DIPARTIMENTO DI IMMUNOREUMATOLOGIA E RIGENERAZIONE TISSUTALE

Dal 15/10/2007 al 14/10/2009  Borsista post doc presso Università degli Studi di BOLOGNA -DIPARTIMENTO FISIOLOGIA UMANA E GENERALE

Dal 02/02/2004 al 14/10/2007 Assegnista di ricerca presso Università degli Studi di BOLOGNA -DIPARTIMENTO FISIOLOGIA UMANA E GENERALE

Dal 01/11/1999 al 31/10/2003 Assegnista di Ricerca presso Università degli Studi di BOLOGNA -DIPARTIMENTO FISIOLOGIA UMANA E GENERALE

 

PERIODI DI ATTIVITA' DI RICERCA SVOLTI ALL'ESTERO:

2004:

Visiting Scientist, (3 mesi) Unité de toxicologie expérimentale, INERIS, Parc Technologique ALATA BP, Verneuil-en-Halatte, Francia. Direttore: Dr. R. De Seze, ambito di progetto : RAMP

2001-2002:

Visiting Scientist, (18 mesi) Department of Physiology and Biophysics, Mount Sinai School of Medicine, NY, NY (USA). Progetto "Studio della regolazione dell'espressione genica nella memoria a lungo termine". Coordinatore: Prof. C.M. Alberini.

1996-1997:

Post-graduate Researcher, (2 anni) Department of Anesthesiology, University of California in Los Angeles, UCLA School of Medicine, CA (USA). Supervisore: Prof. E. Stefani.

 

PUBBLICAZIONI

31. Guidotti S, Minguzzi M, Platano D, Santi S, Trisolino G, Filardo G, Mariani E, Borzì RM. Glycogen Synthase Kinase-3β Inhibition Links Mitochondrial Dysfunction, Extracellular Matrix Remodelling and Terminal Differentiation in Chondrocytes. Sci Rep. 2017 Sep 21;7(1):12059. doi: 10.1038/s41598-017-12129-5.

30. Guidotti S, Minguzzi M, Platano D, Cattini L, Trisolino G, Mariani E, Borzì RM. Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients. PLoS One. 2015 Nov 30;10(11):e0143865. doi: 10.1371/journal.pone.0143865. eCollection 2015.

29. Vandini A, Temmerman R, Frabetti A, Caselli E, Antonioli P, Balboni PG, Platano D, Branchini A, Mazzacane S. Hard surface biocontrol in hospitals using microbial-based cleaning products. PLoS One. 2014 Sep 26;9(9):e108598. doi: 10.1371/journal.pone.0108598. eCollection 2014.

28. Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzì RM, Meliconi R. Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro. PLoS One. 2014 May 12;9(5):e96925. doi: 10.1371/journal.pone.0096925. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105819.

27. Philipot D, Guérit D, Platano D, Chuchana P, Olivotto E, Espinoza F, Dorandeu A, Pers YM, Piette J, Borzi RM, Jorgensen C, Noel D, Brondello JM. p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis. Arthritis Res Ther. 2014 Feb 27;16(1):R58. doi: 10.1186/ar4494.

26. Borzì RM, Guidotti S, Minguzzi M, Facchini A, Platano D, Trisolino G, Filardo G, Cetrullo S, D'Adamo S, Stefanelli C, Facchini A, Flamigni F. Polyamine delivery as a tool to modulate stem cell differentiation in skeletal tissue engineering. Amino Acids. 2014 Mar;46(3):717-28. doi: 10.1007/s00726-013-1607-9. Epub 2013 Nov 19. Review.

25. Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, Flamigni F, Facchini A, Goldring MB, Borzì RM, Marcu KB. IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PLoS One. 2013 Sep 2;8(9):e73024. doi: 10.1371/journal.pone.0073024. eCollection 2013.

24. Arguello AA, Ye X, Bozdagi O, Pollonini G, Tronel S, Bambah-Mukku D, Huntley GW, Platano D, Alberini CM. CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation. J Neurosci. 2013 Feb 20;33(8):3646-58. doi: 10.1523/JNEUROSCI.1635-12.2013.

23. Guidotti S, Facchini A, Platano D, Olivotto E, Minguzzi M, Trisolino G, Filardo G, Cetrullo S, Tantini B, Martucci E, Facchini A, Flamigni F, Borzì RM. Enhanced osteoblastogenesis of adipose-derived stem cells on spermine delivery via β-catenin activation. Stem Cells Dev. 2013 May 15;22(10):1588-601. doi: 10.1089/scd.2012.0399. Epub 2013 Feb 20.

22. Balietti M, Tamagnini F, Fattoretti P, Burattini C, Casoli T, Platano D, Lattanzio F, Aicardi G. Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease. Rejuvenation Res. 2012 Apr;15(2):235-8. doi: 10.1089/rej.2012.1318.

21. Facchini A, Borzì RM, Olivotto E, Platano D, Pagani S, Cetrullo S, Flamigni F. Role of polyamines in hypertrophy and terminal differentiation of osteoarthritic chondrocytes. Amino Acids. 2012 Feb;42(2-3):667-78. doi: 10.1007/s00726-011-1041-9. Epub 2011 Aug 4.

20. Casoli T, Di Stefano G, Fattoretti P, Giorgetti B, Balietti M, Lattanzio F, Aicardi G, Platano D. Dynamin binding protein gene expression and memory performance in aged rats. Neurobiol Aging. 2012 Mar;33(3):618.e15-9. doi: 10.1016/j.neurobiolaging.2010.11.012. Epub 2011 Jan 12.

19. Borzí RM, Olivotto E, Pagani S, Vitellozzi R, Neri S, Battistelli M, Falcieri E, Facchini A, Flamigni F, Penzo M, Platano D, Santi S, Facchini A, Marcu KB. Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors. Arthritis Rheum. 2010 Aug;62(8):2370-81. doi: 10.1002/art.27512.

18. Di Stefano G, Casoli T, Platano D, Fattoretti P, Balietti M, Giorgetti B, Bertoni-Freddari C, Lattanzio F, Aicardi G. Differences in gene expression in the hippocampus of aged rats are associated with better long-term memory performance in a passive avoidance test. Rejuvenation Res. 2010 Apr-Jun;13(2-3):224-8. doi: 10.1089/rej.2009.0965.

17. Balietti M, Giorgetti B, Di Stefano G, Casoli T, Platano D, Solazzi M, Bertoni-Freddari C, Aicardi G, Lattanzio F, Fattoretti P. A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats. Micron. 2010 Feb;41(2):143-8. doi: 10.1016/j.micron.2009.08.010. Epub 2009 Oct 8.

16. Balietti M, Fattoretti P, Giorgetti B, Casoli T, Di Stefano G, Solazzi M, Platano D, Aicardi G, Bertoni-Freddari C. A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes. Ann N Y Acad Sci. 2009 Aug;1171:377-84. doi: 10.1111/j.1749-6632.2009.04704.x.

15. Balietti M, Fattoretti P, Giorgetti B, Casoli T, Di Stefano G, Platano D, Aicardi G, Lattanzio F, Bertoni-Freddari C. Effect of two medium chain triglycerides-supplemented diets on synaptic morphology in the cerebellar cortex of late-adult rats. Microsc Res Tech. 2009 Dec;72(12):933-8. doi: 10.1002/jemt.20737.

14. Balietti M, Giorgetti B, Fattoretti P, Grossi Y, Di Stefano G, Casoli T, Platano D, Solazzi M, Orlando F, Aicardi G, Bertoni-Freddari C. Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats. Rejuvenation Res. 2008 Jun;11(3):631-40. doi: 10.1089/rej.2007.0650.

13. Platano D, Fattoretti P, Balietti M, Giorgetti B, Casoli T, Di Stefano G, Bertoni-Freddari C, Aicardi G. Synaptic remodeling in hippocampal CA1 region of aged rats correlates with better memory performance in passive avoidance test. Rejuvenation Res. 2008 Apr;11(2):341-8. doi: 10.1089/rej.2008.0725.

12. Platano D, Fattoretti P, Balietti M, Bertoni-Freddari C, Aicardi G. Long-term visual object recognition memory in aged rats. Rejuvenation Res. 2008 Apr;11(2):333-9. doi: 10.1089/rej.2008.0687.

11. Platano D, Mesirca P, Paffi A, Pellegrino M, Liberti M, Apollonio F, Bersani F, Aicardi G. Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba 2+ currents through voltage-gated calcium channels in rat cortical neurons. Bioelectromagnetics. 2007 Dec;28(8):599-607.

10. Platano D, Bertoni-Freddari C, Fattoretti P, Giorgetti B, Grossi Y, Balietti M, Casoli T, Di Stefano G, Aicardi G.Structural synaptic remodeling in the perirhinal cortex of adult and old rats following object-recognition visual training. Rejuvenation Res. 2006 Spring;9(1):102-6.

9. Platano D, Magli MC, Ferraretti AP, Gianaroli L, Aicardi G. L- and T-type voltage-gated Ca2+ channels in human granulosa cells: functional characterization and cholinergic regulation. J Clin Endocrinol Metab. 2005 Apr;90(4):2192-7. Epub 2005 Jan 25.

8. Platano D, Qin N, Noceti F, Birnbaumer L, Stefani E, Olcese R. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophys J. 2000 Jun;78(6):2959-72.

7. Birnbaumer L, Qin N, Olcese R, Tareilus E, Platano D, Costantin J, Stefani E. Structures and functions of calcium channel beta subunits. J Bioenerg Biomembr. 1998 Aug;30(4):357-75. Review.

6. Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. FEBS Lett. 1998 May 1;427(1):96-102.

5. Qin N, Platano D, Olcese R, Costantin JL, Stefani E, Birnbaumer L. Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4690-5.

4. Costantin JL, Qin N, Zhou J, Platano D, Birnbaumer L, Stefani E. Long lasting facilitation of the rabbit cardiac Ca2+ channel: correlation with the coupling efficiency between charge movement and pore opening. FEBS Lett. 1998 Feb 20;423(2):213-7.

3. Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L. Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8866-71.

2. Birnbaumer L, Zhu X, Jiang M, Boulay G, Peyton M, Vannier B, Brown D, Platano D, Sadeghi H, Stefani E, Birnbaumer M. On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15195-202. Review.

1. Platano D, Pollo A, Carbone E, Aicardi G. Up-regulation of L- and non-L, non-N-type Ca2+ channels by basal and stimulated protein kinase C activation in insulin-secreting RINm5F cells. FEBS Lett. 1996 Aug 5;391(1-2):189-94.


 

 

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