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Claudio Stefanelli

Professore ordinario

Dipartimento di Scienze per la Qualità della Vita

Settore scientifico disciplinare: BIO/10 BIOCHIMICA

Direttore Dipartimento di Scienze per la Qualità della Vita

Pubblicazioni

Published papers (1995-2017)

- Croco E, Marchionni S, Bocchini M, Angeloni C, Stamato T, Stefanelli C, Hrelia S, Sell C, Lorenzini A. DNA Damage Detection by 53BP1: Relationship to Species Longevity.  Journal of Gerontology A Biol Sci Med Sci. 2017 72  763-770 (2017)

-  Jürimäe J, Tillmann V, Cicchella A, Stefanelli C, Võsoberg K, Tamm AL, Jürimäe T.  Increased sclerostin and preadipocyte factor-1 levels in prepubertal rhythmic gymnasts: associations with bone mineral density, body composition, and adipocytokine values.  Osteoporosis International. 27 1239-1243 (2016)

- Bartolomei S, Hoffman  JR, Stout  JR, Zini  M, Stefanelli  C, Merni  F. Comparison of block versus weekly undulating periodization models on endocrine and strength changes in male atheletes. Kinesiology.   48  71-78 (2016)

- Pinna C, Vecchiato CG, Zaghini G, Grandi M, Nannoni E, Stefanelli C, Biagi G. In vitro influence of dietary protein and fructooligosaccharides on metabolism of canine fecal microbiota. BMC Veterinary Research 12 53 (2016).

-  Cappadone C, Stefanelli C, Malucelli E, Zini M, Onofrillo C, Locatelli A, Rambaldi M, Sargenti A, Merolle L, Farruggia G, Graziadio A, Montanaro L, Iotti S. p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells. Biochemical and Biophysical Research Communications 467 348-353 ( 2015)

- Leoni A, Locatelli A, Morigi R, Rambaldi M, Cappadone C, Farruggia G, Iotti S, Merolle L, Zini M, Stefanelli C. Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells. Europen Journal of Medicinal Chemistry 79:382-390 (2014).

-  Borzì RM, Guidotti S, Minguzzi M, Facchini A, Platano D, Trisolino G, Filardo  G, Cetrullo S, D'Adamo S, Stefanelli C, Facchini A, Flamigni F. Polyamine delivery as a tool to modulate stem cell differentiation in skeletal tissue engineering. Amino Acids 46(3):717-28 (2014)

-  Pinna C, Stefanelli C, Biagi G. In vitro effect of dietary protein level and nondigestible oligosaccharides on feline fecal microbiota. Journal of Animal Science 92(12):5593-602 (2014).

-  Cicchella A, Jürimäe T, Stefanelli C, Purge P, Lätt E, Saar M.  Correlations of skinfold thicknesses and circumferences at exactly defined body sites with leptin in 10-12-year-old boys with different BMIs. Collegium Antropologicum  38(2):459-65 (2014).

-  Minarini A, Zini M, Milelli A, Tumiatti V, Marchetti C, Nicolini B, Falconi M, Farruggia G, Cappadone C, Stefanelli C. Synthetic polyamines activating autophagy: effects on cancer cell death. European Journal of Medicinal Chemistry   67:359-66 (2013)

-  Cicchella A, Stefanelli C, Jürimäe T, Saar M, Purge P. Moderate physical activity correlates with elevated leptin in physically active 10-12-year-old boys with normal BMI. Perceptual Motor Skills  117(2):358-66 (2013)

-  Cicchella A, Stefanelli C, Purge P, Lätt E, Saar M, Jürimäe T. The associations between peak O2 onsumption and leptin in 10- to 12-year-old boys. Clinical Physiology and Functional Imaging 33(4):313-6 (2013)

-  Biagi G, Cipollini I, Bonaldo A, Grandi M, Pompei A, Stefanelli C, Zaghini G.  Effect of feeding a selected combination of galacto-oligosaccharides and a strain of Bifidobacterium pseudocatenulatum on the intestinal microbiota of cats. American Journal of Veterinary Research  74(1):90-5 (2013)

-  Milelli A, Tumiatti V, Micco M, Rosini M, Zuccari G, Raffaghello L, Bianchi G, Pistoia V, Fernando Díaz J, Pera B, Trigili C, Barasoain I, Musetti C, Toniolo M, Sissi C, Alcaro S, Moraca F, Zini M, Stefanelli C, Minarini A. Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents. European Journal of Medicinal Chemistry  57:417-28 (2012)

-  Passariello CL, Gottardi D, Cetrullo S, Zini M, Campana G, Tantini B, Pignatti C, Flamigni F, Guarnieri C, Caldarera CM, Stefanelli C. Evidence that AMP-activated protein kinase can negatively modulate Ornithine decarboxylase activity in cardiac myoblasts.  Biochimica et Biophysica Acta Mol.Cell.Res. 1823 800-807, 2012

-  Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Stefanelli C, Masotti L, Nguyen TL, Hamel E, Shoemaker RH.   Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Analogues: Synthesis, Cytotoxic Activity, and Study of the Mechanism of Action .  Journal of Medicinal Chemistry     55 2078-88, 2012

-  Cetrullo S, Tantini B, Flamigni F, Pazzini C, Facchini A, Stefanelli C, Caldarera CM, Pignatti C. Antiapoptotic and antiautophagic effects of eicosapentaenoic Acid in cardiac myoblasts exposed to palmitic Acid.     Nutrients  4 78-90, 2012

-  R  Gruodyte,  J  Jurimae,  M  Saar,  A  Cicchella,  C Stefanelli,  C  Passariello,  T  Jurimae,  Bone mineral density and hormonal status in adolescent girls. Acta Kinesiologiae Universitatis Tartuensis 18:56-68 (2012)

-  Passariello CL, Zini M, Nassi PA, Pignatti C, Stefanelli C.  Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts.  Biochemical and Biophysical Research Communications 407:512-516, 2011

-  Cetrullo S, Tantini B, Facchini A, Pignatti C, Stefanelli C, Caldarera CM, Flamigni F.         A pro-survival effect of polyamine depletion on norepinephrine-mediated apoptosis in cardiac cells: role of signaling enzymes. Amino Acids 40:1127-1137, 2011

-  Jürimäe J, Gruodyte R, Saar M, Cicchella A, Stefanelli C, Passariello C, Maasalu K, Jürimäe T, von Duvillard SP. Plasma visfatin and adiponectin concentrations in physically active adolescent girls: relationships with insulin sensitivity and body composition variables.  J Pediatr Endocrinol Metab 24:419-425, 2011

-  Passariello CL, Gruodytė R, Hiio K, Mäestu J, Jürimäe J, Saar M, Cicchella A, Stefanelli C, Jürimäe T.       ADIPOQ SNP45 associated with lean body mass in physically active normal weight adolescent girls.     American  Journal of  Human  Biology   22:813-818, 2010

-  Muscari C, Capanni C, Giordano E, Stefanelli C, Bonavita F, Stanic I, Bonafè F, Caldarera CM, Guarnieri C.       Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia.    Journal of  Surgical Research  164:27-35, 2010

-  Gruodytė R, Jürimäe J, Cicchella A, Stefanelli C, Passariello C, Jürimäe T.     Adipocytokines and bone mineral density in adolescent female athletes.     Acta Paediatrica   99:1879-1884, 2010

-  Andreani A, Bellini S, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Zini M, Stefanelli C, Masotti L, Shoemaker RH.      Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer  cells.    Journal of  Medicinal Chemistry   53:5567-5575, 2010

-  Tumiatti V, Milelli A, Minarini A, Micco M, Gasperi Campani A, Roncuzzi L, Baiocchi D, Marinello J, Capranico G, Zini M, Stefanelli C, Melchiorre C.      Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.    Journal of  Medicinal Chemistry   52: 7873-7877, 2009

-  M. Zini, C. L. Passariello, D. Gottardi, S. Cetrullo, F. Flamigni, C. Pignatti , A. Minarini, V. Tumiatti, A. Milelli, C. Melchiorre, C. Stefanelli.  Cytotoxicity of Methoctramine and Methoctramine-related Polyamines.   Chemico-Biological Interactions   181: 409-416. 2009

-  Stanic' I, Facchini A, Borzì RM, Stefanelli C, Flamigni F.    The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines.  Journal of Cellular Physiology  219:209-216, 2009

-  Stanic, S. Cetrullo, A. Facchini, C. Stefanelli, R.M. Borzì, B. Tantini, C. Guarnieri, C.M. Caldarera, F. Flamigni.     Effect of the Polyamine Analogue N1,N11- Diethylnorspermine on Cell Survival and Susceptibility to Apoptosis of Human Chondrocytes.    Journal of Cellular Physiology  216:153-161, 2008

-  A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, L. Varoli, N. Calonghi, C. Cappadone, M. Voltattorni, M. Zini, C. Stefanelli, L. Masotti, R. H. Shoemaker.     Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones: Selectivity Against Colon Tumor Cells and Effect on Cell Cycle-Related Events.   Journal of Medicinal Chemistry  51:7508-7513, 2008

-  A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, L. Varoli, N. Calonghi, C. Cappadone, G. Farruggia, M. Zini, C. Stefanelli, L. Masotti, N.S. Radin,  R. H. Shoemaker.     New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogs.    Journal of Medicinal Chemistry   51:809-816, 2008

-  A. Andreani, S Burnelli, M. Granaiola, A Leoni, A Locatelli, R Morigi, M Rambaldi, L Varoli, N. Calonghi, C Cappadone, G. Farruggia, M. Zini, C. Stefanelli,  L  Masotti.     Substituted E-3-(2-Chloro-3-indolylmethylene)1,3-dihydroindol-2-ones With Antitumor Activity. Effect on the Cell Cycle and Apoptosis.   Journal of Medicinal Chemistry    50:3167-3172, 2007

-  I. Stanic. A. Facchini, R.M. Borzì, R. Vitellozzi, C. Stefanelli, M.B. Goldring, C. Guarnieri, A. Facchini, F. Flamigni.     Polyamine depletion inhibits apoptosis following blocking of survival pathways  in human chondrocytes stimulated  by Tumor Necrosis Factor- α .   Journal of Cellular Physiology  206:38-146, 2006

-  B. Tantini, E. Fiumana, S. Cetrullo, C. Pignatti, F. Bonavita, L.M. Shantz, E. Giordano, C. Muscari, F. Flamigni, C. Guarnieri, C. Stefanelli, C.M. Caldarera.     Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia.   Journal of Molecular and Cellular Cardiology   40:775-782: 2006

-  A. Andreani, S. Burnelli, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, L. Varoli, G. Farruggia, C. Stefanelli, L. Masotti, M.W. Kunkel.     Synthesis and Antitumor Activity of Guanylhydrazones From 6-(2,4-dichloro-5-nitrophenyl)- and 6-pyridyl-imidazo[2,1-b]thiazole.   Journal of Medicinal Chemistry     49:7897-7901, 2006

-  A. Facchini, R.M. Borzì, K.B. Marcu, C. Stefanelli, E. Olivotto, M.B. Goldring, A. Facchini, F. Flamigni.     Polyamine depletion inhibits NF-kB binding to DNA and interleukin-8 production in human chondrocytes stimulated  by Tumor Necrosis Factor- α .   Journal of Cellular Physiology  204:956-963, 2005

-  C. Muscari,F. Bonafè, I. Stanic, F. Flamigni, C. Stefanelli, F. Farruggia, C. Guarnieri,C.M. Caldarera.     Polyamine depletion reduces TNF a /mg132 -induced apoptosis in bone marrow stromal cells.   Stem Cells 23:983-99, 2005

-  Dalla Via L, Salvi M, Di Noto V, Stefanelli C, Toninello A.     Membrane binding and transport of N-aminoethyl-1,2-diamino ethane (dien) and N-aminopropyl-1,3-diamino propane (propen) by rat liver mitochondria and their effects on membrane permeability transition.   Molecular Membrane Biology  21:109-118, 2004

-  B.Tantini, C. Pignatti, M. Fattori, E. Fiumana, A. Facchini, C. Stefanelli, C.M. Caldarera, A.E. Pegg, F. Flamigni.     Polyamine depletion inhibits etoposide-induced NF-kB activation in transformend mouse fibroblasts.   Amino Acids  27:207-214, 2004

-  C. Pignatti, B. Tantini, C. Stefanelli, F. Flamigni.     Signal Transduction pathways linking polyamines to apoptosis.   Amino Acids  27:359-365, 2004

-  Facchini A, Zanella B, Stefanelli C, Guarnieri C, Flamigni F.     Effect of green tea extract on the induction of ornithine decarboxylase and the activation of extracellular signal-regulated kinase in bladder carcinoma ECV304 cells.   Nutrition And Cancer  47:104-110, 2003

-  C. Pignatti, C. Stefanelli.     Ischemia/reperfusion-induced apoptosis: connecting nitric oxide and cell cycle regulator.   Cardiovascular Research  59:268-270, 2003

-  A. Bonavita, C. Stefanelli, E. Giordano, M. Columbaro, A. Facchini, F. Bonafè, C.M. Caldarera, C. Guarnieri.     H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMA.   FEBS Letters  536:85-91, 2003

-  B. Tantini, C. Pignatti, F. Flamigni, C. Stefanelli, M. Fattori, A. Facchini, E. Giordano, C. Clo and C.M. Caldarera.      Signaling pathways involved in the stimulation of DNA synthesis by Tumor Necrosis Facto and Lipopolysaccharide in chick embryo cardiomyocytes.       In:  Signal transduction in cardiac hypertrophy (N.S. Dahalla, L.V. Hryshko, E. Kardami and P.K. Singal eds) Kluwer, Boston. 359-371, 2003

-  C. Stefanelli, C. Pignatti, B. Tantini, E. Giordano, F. Bonavita, M. Zini, F. Flamigni, C. Muscari, C. Clo, C.M. Caldarera, C. Guarnieri.    Caspase activation in a cardiac cell-free model of apoptosis.   In:  Signal transduction in cardiac hypertrophy (N.S. Dahalla, L.V. Hryshko, E. Kardami and P.K. Singal eds) Kluwer, Boston. 199-206, 2003

-  C. Trevisani, P. Caraceni, M. Simoncini, M. Micati, M. Domenicali, F. Dazzani, A. Zambruni, C. Stefanelli, G. Grazi , B. Nardo, C. Guarnieri, M. Bernardi.     Evidence of oxidative imbalance in long-term liver transplant patients.   Digestive and Liver Diseases 34:279-284, 2002

-  C. Stefanelli, B. Tantini, M. Fattori, I. Stanic', C. Pignatti, C. Clo, C. Guarnieri, C.M. Caldarera, C.A. Mackintosh, A.E. Pegg, F. Flamigni.     Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.   FEBS Letters  527:223-228, 2002

-  B. Tantini, C. Pignatti, M. Fattori, F. Flamigni, C. Stefanelli, E. Giordano, M. Menegazi, C. Clo, C.M. Caldarera.      NF-kB and ERK cooperate to stimulate DNA synthesis by inducing  Ornithine Decarboxylase and Nitric Oxide Synthase in cardiomyocytes treated with TNF and LPS.    FEBS Letters  451:95-98, 2002

-  A. Kowluru, L.M. Modrick, HQ Chen, C. Stefanelli.    Activation of acetyl-CoA carboxylase by a glutamate and magnesium-sensitive protein phosphatase in the islet beta-cell.    Diabetes 50:1580-1587, 2001

-  C. Stefanelli, C. Pignatti,  B. Tantini, M. Fattori, I. Stanic, C.A Mackintosh, F. Flamigni, C. Guarnireri, C.M. Caldarera, A.E. Pegg.     Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.   Biochemical Journal  355:199-206, 2001

-  F. Flamigni, A. Facchini, I. Stanic, E. Giordano, B. Tantini, C. Stefanelli.      Control of survival of  proliferating L1210 cells by soluble guanylate cyclase and p44/42 mitogen-activated protein kinase modulators.   Biochemical Pharmacology  62:319-328, 2001

-  B. Tantini, F. Flamigni, C. Pignatti, C. Stefanelli, M. Fattori, A. Facchini, E. Giordano, C. Clo, C.M. Caldarera.     Polyamines, nitric oxide and cyclic GMP mediate stimulation of DNA synthesis by tumor  necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.   Cardiovascular Research  49:408-416, 2001

-  F. Flamigni, A. Facchini, E. Giordano, B. Tantini, C. Stefanelli.     Signaling pathways leading to the induction of ornithine decarboxylase: opposite effects of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitors.  Biochemical Pharmacology  61:25-32, 2001

-  C. Stefanelli, I. Stanic, M. Zini, F. Bonavita, F. Flamigni, L. Zambonin, L. Landi, C. Pignatti, C. Guarnieri, C.M. Caldarera.     Polyamines directly induce release of cytochrome c from heart mitochondria.   Biochemical Journal 347:875-880, 2000

-  C. Stefanelli, F. Bonavita, I. Stanic, C. Pignatti, F. Flamigni, C. Guarnieri, C.M. Caldarera.     Spermine triggers the activation of caspase-3 in a cell-free model of apoptosis.   FEBS Letters  451:95-98, 1999

-  C. Stefanelli, C. Pignatti, B. Tantini, I. Stanic, F. Bonavita, C. Muscari, C. Guarnieri, C. Clo, C.M. Caldarera.     Nitric oxide can function as either a killer molecule or an antiapoptotic effector in cardiomyocytes.   Biochimica et Biophysica Acta, Mol.Cell.Res.  145:406-413, 1999

-  F. Flamigni, A. Facchini, C. Capanni, C. Stefanelli, B. Tantini, C.M. Caldarera.     p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukaemia L1210 cells.   Biochemical Journal 341:363-369, 1999

-  C. Pignatti, B. Tantini, C. Stefanelli, E. Giordano, F. Bonavita, C. Clo, C.M. Caldarera.      Nitric oxide mediates either proliferation or cell death in cardiomyocytes. Involvement of polyamines.    Amino Acids 16:181-190, 1999

-  C. Stefanelli, C.M. Caldarera.     Meccanismi molecolari della morte cellulare programmata.   Cardiologia 43:135-140, 1998

-  C. Stefanelli, F. Bonavita, I. Stanic, M. Mignani, A. Facchini, C. Pignatti, F. Flamigni, C.M. Caldarera.     Spermine causes caspase activation in leukaemia cells.   FEBS Letters 437:233-236, 1998

-  C. Stefanelli, F. Bonavita, I. Stanic, C.Pignatti, G. Farruggia, L. Masotti, C. Guarnieri, C.M. Caldarera.     Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome.   Biochemical Journal  332:661-665, 1998

-  C. Pignatti, I. Stanic, C. Stefanelli, B. Tantini, C. Rossoni,  F. Flamigni.     Modulation of the induction of ornithine decarboxylase by some opioid receptor agonist in immune cells and cardiomyocytes.   Molecular and Cellular Biochemistry  185:47-53, 1998

-  C. Stefanelli, I. Stanic, F. Bonavita, F. Flamigni, C.Pignatti, C. Guarnieri, C.M. Caldarera.    Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide-ribonucleoside, a cell-permeable activator of AMP-activated protein kinase.   Biochemical and Biophysical Research Communications 243:821-82, 1998

-  Flamigni F, Marmiroli S, Capanni C, Stefanelli C, Guarnieri C, Caldarera CM.      Phosphatidylinositol 3-kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth.   Biochemical and Biophysical Research Communications 239:729-733, 1997

-  Flamigni F, Faenza I, Marmiroli S, Stanic' I, Giaccari A, Muscari C, Stefanelli C, Rossoni C.      Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells.  Biochemical Journal  324: 783-789, 1997

-  Stefanelli C, Bonavita F, Stanic' I, Farruggia G, Falcieri E, Robuffo I, Pignatti C, Muscari C, Rossoni C, Guarnieri C, Caldarera CM.      ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis. Biochemical Journal  322: 909-917, 1997

-  Muscari C, Giaccari A, Stefanelli C, Viticchi C, Giordano E, Guarnieri C, Caldarera CM.    Presence of a DNA-4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse cardiac mitochondrial DNA during aging.   Aging 8:429-433, 1996

-  Flamigni F, Stefanelli C, Stanic I, Muscari C, Giaccari A, Rossoni C. Inhibition of the expression of ornithine decarboxylase by some kappa-opioidergic 210 cells.      Biochimica et Biophysica Acta  1311:204-210, 1996

-  Muscari C, Guarnieri C, Stefanelli C, Giaccari A, Caldarera CM.    Protective effect of spermine on DNA exposed to oxidative stress.  Molecular and Cellular Biochemistry  144:15-129, 1995

-  Muscari C, Biagetti L, Stefanelli C, Giordano E, Guarnieri C, Caldarera CM.     Adaptive changes in coenzyme Q biosynthesis to myocardial reperfusion in young and aged rats.  Journal of Molecular and Cellular Cardiology    27:283-291, 1995    

-  Stefanelli C, Stanic I, Bonavita F, Muscari C, Pignatti C, Rossoni C, Caldarera CM.     Oxygen tension influences DNA fragmentation and cell death in glucocorticoid-treated thymocytes.      Biochemical and Biophysical Research Communications 212:300-306,1995

 



 

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