1: Agnew HN, Atack JM, Fernando ARD, Waters SN, van der Linden M, Smith E, Abell
AD, Brazel EB, Paton JC, Trappetti C. Uncovering the link between the
SpnIII restriction modification system and LuxS in Streptococcus
pneumoniae meningitis isolates. Front Cell Infect Microbiol. 2023 May
1;13:1177857. doi: 10.3389/fcimb.2023.1177857. PMID: 37197203; PMCID:
PMC10184825.
2: Trappetti C, Paton JC. A selfish bacteriocin dictates pneumococcal
domination. Cell Host Microbe. 2023 Jan 11;31(1):7-8. doi:
10.1016/j.chom.2022.12.006. PMID: 36634623.
3: Tikhomirova A, Zilm PS, Trappetti C, Paton JC, Kidd SP. The central role of
arginine in Haemophilus influenzae survival in a polymicrobial environment with
Streptococcus pneumoniae and Moraxella catarrhalis. PLoS One. 2022 Jul
25;17(7):e0271912. doi: 10.1371/journal.pone.0271912. PMID: 35877653; PMCID:
PMC9312370.
4: Phillips ZN, Trappetti C, Van Den Bergh A, Martin G, Calcutt A, Ozberk V,
Guillon P, Pandey M, von Itzstein M, Swords WE, Paton JC, Jennings MP, Atack JM.
Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine
Candidate Expression. Microbiol Spectr. 2022 Jun 29;10(3):e0091622. doi:
10.1128/spectrum.00916-22. Epub 2022 May 10. PMID: 35536022; PMCID: PMC9241608.
5: Agnew HN, Brazel EB, Tikhomirova A, van der Linden M, McLean KT, Paton JC,
Trappetti C. <i>Streptococcus pneumoniae</i> Strains Isolated From a Single
Pediatric Patient Display Distinct Phenotypes. Front Cell Infect Microbiol. 2022
Mar 31;12:866259. doi: 10.3389/fcimb.2022.866259. PMID: 35433506; PMCID:
PMC9008571.
6: Tikhomirova A, Brazel EB, McLean KT, Agnew HN, Paton JC, Trappetti C. The
Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate
947. Pathogens. 2022 Feb 7;11(2):216. doi: 10.3390/pathogens11020216. PMID:
35215159; PMCID: PMC8877971.
7: Adams FG, Trappetti C, Waters JK, Zang M, Brazel EB, Paton JC, Snel MF,
Eijkelkamp BA. To Make or Take: Bacterial Lipid Homeostasis during Infection.
mBio. 2021 Jun 29;12(3):e0092821. doi: 10.1128/mBio.00928-21. Epub 2021 Jun 17.
PMID: 34134515; PMCID: PMC8262940.
8: Zang M, MacDermott-Opeskin H, Adams FG, Naidu V, Waters JK, Carey AB,
Ashenden A, McLean KT, Brazel EB, Jiang JH, Panizza A, Trappetti C, Paton JC,
Peleg AY, Köper I, Paulsen IT, Hassan KA, O'Mara ML, Eijkelkamp BA. The Membrane
Composition Defines the Spatial Organization and Function of a Major
Acinetobacter baumannii Drug Efflux System. mBio. 2021 Jun 29;12(3):e0107021.
doi: 10.1128/mBio.01070-21. Epub 2021 Jun 17. PMID: 34134514; PMCID: PMC8262998.
9: Adams FG, Pokhrel A, Brazel EB, Semenec L, Li L, Trappetti C, Paton JC, Cain
AK, Paulsen IT, Eijkelkamp BA. <i>Acinetobacter baumannii</i> Fatty Acid
Desaturases Facilitate Survival in Distinct Environments. ACS Infect Dis. 2021
Aug 13;7(8):2221-2228. doi: 10.1021/acsinfecdis.1c00192. Epub 2021 Jun 8. PMID:
34100578.
10: Minhas V, Paton JC, Trappetti C. Sickly Sweet - How Sugar Utilization
Impacts Pneumococcal Disease Progression. Trends Microbiol. 2021
Sep;29(9):768-771. doi: 10.1016/j.tim.2021.01.016. Epub 2021 Feb 18. PMID:
33612397.
11: Tikhomirova A, Trappetti C, Paton JC, Watson-Haigh N, Wabnitz D, Jervis-
Bardy J, Jardeleza C, Kidd SP. A single nucleotide polymorphism in an IgA1
protease gene determines Streptococcus pneumoniae adaptation to the middle ear
during otitis media. Pathog Dis. 2021 Jan 9;79(1):ftaa077. doi:
10.1093/femspd/ftaa077. PMID: 33301554.
12: McLean KT, Tikhomirova A, Brazel EB, Legendre S, Haasbroek G, Minhas V,
Paton JC, Trappetti C. Site-Specific Mutations of GalR Affect Galactose
Metabolism in Streptococcus pneumoniae. J Bacteriol. 2020 Dec
7;203(1):e00180-20. doi: 10.1128/JB.00180-20. PMID: 33046563; PMCID: PMC7723958.
13: Minhas V, Aprianto R, McAllister LJ, Wang H, David SC, McLean KT, Comerford
I, McColl SR, Paton JC, Veening JW, Trappetti C. In vivo dual RNA-seq reveals
that neutrophil recruitment underlies differential tissue tropism of
Streptococcus pneumoniae. Commun Biol. 2020 Jun 5;3(1):293. doi:
10.1038/s42003-020-1018-x. PMID: 32504007; PMCID: PMC7275033.
14: Andreassen PR, Trappetti C, Minhas V, Nielsen FD, Pakula K, Paton JC,
Jørgensen MG. Host-glycan metabolism is regulated by a species-conserved two-
component system in Streptococcus pneumoniae. PLoS Pathog. 2020 Mar
4;16(3):e1008332. doi: 10.1371/journal.ppat.1008332. PMID: 32130269; PMCID:
PMC7075642.
15: Kwambana-Adams BA, Mulholland EK, Satzke C; ISPPD group. State-of-the-art in
the pneumococcal field: Proceedings of the 11<sup>th</sup> International
Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11). Pneumonia
(Nathan). 2020 Feb 5;12:2. doi: 10.1186/s41479-019-0064-y. PMID: 32042572;
PMCID: PMC7001343.
16: Paton JC, Trappetti C. <i>Streptococcus pneumoniae</i> Capsular
Polysaccharide. Microbiol Spectr. 2019 Mar;7(2). doi:
10.1128/microbiolspec.GPP3-0019-2018. PMID: 30977464.
17: Minhas V, Harvey RM, McAllister LJ, Seemann T, Syme AE, Baines SL, Paton JC,
Trappetti C. Capacity To Utilize Raffinose Dictates Pneumococcal Disease
Phenotype. mBio. 2019 Jan 15;10(1):e02596-18. doi: 10.1128/mBio.02596-18. PMID:
30647157; PMCID: PMC6336424.
18: Paton JC, Trappetti C. Stand by to repel boarders. Nat Microbiol. 2019
Jan;4(1):8-9. doi: 10.1038/s41564-018-0324-2. PMID: 30546097.
19: Tikhomirova A, Trappetti C, Standish AJ, Zhou Y, Breen J, Pederson S, Zilm
PS, Paton JC, Kidd SP. Specific growth conditions induce a Streptococcus
pneumoniae non-mucoidal, small colony variant and determine the outcome of its
co-culture with Haemophilus influenzae. Pathog Dis. 2018 Oct 1;76(7). doi:
10.1093/femspd/fty074. PMID: 30285091.
20: Trappetti C, McAllister LJ, Chen A, Wang H, Paton AW, Oggioni MR, McDevitt
CA, Paton JC. Autoinducer 2 Signaling via the Phosphotransferase FruA Drives
Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence.
mBio. 2017 Jan 24;8(1):e02269-16. doi: 10.1128/mBio.02269-16. PMID: 28119473;
PMCID: PMC5263250.
21: Trappetti C, Paton JC. Host-to-Host Transmission of the Pneumococcus-New
Victims of a Toxic Relationship. Cell Host Microbe. 2017 Jan 11;21(1):5-6. doi:
10.1016/j.chom.2016.12.011. PMID: 28081444.
22: Harvey RM, Trappetti C, Mahdi LK, Wang H, McAllister LJ, Scalvini A, Paton
AW, Paton JC. The Variable Region of Pneumococcal Pathogenicity Island 1 Is
Responsible for Unusually High Virulence of a Serotype 1 Isolate. Infect Immun.
2016 Jan 11;84(3):822-32. doi: 10.1128/IAI.01454-15. PMID: 26755156; PMCID:
PMC4771350.
23: Tikhomirova A, Trappetti C, Paton JC, Kidd SP. The outcome of H. influenzae
and S. pneumoniae inter-species interactions depends on pH, nutrient
availability and growth phase. Int J Med Microbiol. 2015 Dec;305(8):881-92. doi:
10.1016/j.ijmm.2015.09.003. Epub 2015 Sep 14. PMID: 26481153.
24: Amin Z, Harvey RM, Wang H, Hughes CE, Paton AW, Paton JC, Trappetti C.
Isolation site influences virulence phenotype of serotype 14 Streptococcus
pneumoniae strains belonging to multilocus sequence type 15. Infect Immun. 2015
Dec;83(12):4781-90. doi: 10.1128/IAI.01081-15. Epub 2015 Sep 28. PMID: 26416904;
PMCID: PMC4645380.
25: Wright EA, Di Lorenzo V, Trappetti C, Liciardi M, Orru G, Viti C, Bronowski
C, Hall AJ, Darby AC, Oggioni MR, Winstanley C. Divergence of a strain of
Pseudomonas aeruginosa during an outbreak of ovine mastitis. Vet Microbiol. 2015
Jan 30;175(1):105-13. doi: 10.1016/j.vetmic.2014.11.011. Epub 2014 Nov 20. PMID:
25475851.
26: Manso AS, Chai MH, Atack JM, Furi L, De Ste Croix M, Haigh R, Trappetti C,
Ogunniyi AD, Shewell LK, Boitano M, Clark TA, Korlach J, Blades M, Mirkes E,
Gorban AN, Paton JC, Jennings MP, Oggioni MR. A random six-phase switch
regulates pneumococcal virulence via global epigenetic changes. Nat Commun. 2014
Sep 30;5:5055. doi: 10.1038/ncomms6055. PMID: 25268848; PMCID: PMC4190663.
27: Harvey RM, Hughes CE, Paton AW, Trappetti C, Tweten RK, Paton JC. The impact
of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-
dependent. PLoS One. 2014 Aug 8;9(8):e103625. doi: 10.1371/journal.pone.0103625.
PMID: 25105894; PMCID: PMC4126675.
28: Trappetti C, van der Maten E, Amin Z, Potter AJ, Chen AY, van Mourik PM,
Lawrence AJ, Paton AW, Paton JC. Site of isolation determines biofilm formation
and virulence phenotypes of Streptococcus pneumoniae serotype 3 clinical
isolates. Infect Immun. 2013 Feb;81(2):505-13. doi: 10.1128/IAI.01033-12. Epub
2012 Dec 3. PMID: 23208608; PMCID: PMC3553814.
29: Ong CL, Potter AJ, Trappetti C, Walker MJ, Jennings MP, Paton JC, McEwan AG.
Interplay between manganese and iron in pneumococcal pathogenesis: role of the
orphan response regulator RitR. Infect Immun. 2013 Feb;81(2):421-9. doi:
10.1128/IAI.00805-12. Epub 2012 Nov 26. PMID: 23184523; PMCID: PMC3553810.
30: Potter AJ, Trappetti C, Paton JC. Streptococcus pneumoniae uses glutathione
to defend against oxidative stress and metal ion toxicity. J Bacteriol. 2012
Nov;194(22):6248-54. doi: 10.1128/JB.01393-12. Epub 2012 Sep 14. PMID: 22984260;
PMCID: PMC3486410.
31: Gualdi L, Hayre JK, Gerlini A, Bidossi A, Colomba L, Trappetti C, Pozzi G,
Docquier JD, Andrew P, Ricci S, Oggioni MR. Regulation of neuraminidase
expression in Streptococcus pneumoniae. BMC Microbiol. 2012 Sep 11;12:200. doi:
10.1186/1471-2180-12-200. PMID: 22963456; PMCID: PMC3509027.
32: Ogunniyi AD, Mahdi LK, Trappetti C, Verhoeven N, Mermans D, Van der Hoek MB,
Plumptre CD, Paton JC. Identification of genes that contribute to the
pathogenesis of invasive pneumococcal disease by in vivo transcriptomic
analysis. Infect Immun. 2012 Sep;80(9):3268-78. doi: 10.1128/IAI.00295-12. Epub
2012 Jul 9. PMID: 22778095; PMCID: PMC3418729.
33: Kadioglu A, Cuppone AM, Trappetti C, List T, Spreafico A, Pozzi G, Andrew
PW, Oggioni MR. Sex-based differences in susceptibility to respiratory and
systemic pneumococcal disease in mice. J Infect Dis. 2011 Dec 15;204(12):1971-9.
doi: 10.1093/infdis/jir657. Epub 2011 Oct 21. PMID: 22021621.
34: Trappetti C, Potter AJ, Paton AW, Oggioni MR, Paton JC. LuxS mediates iron-
dependent biofilm formation, competence, and fratricide in Streptococcus
pneumoniae. Infect Immun. 2011 Nov;79(11):4550-8. doi: 10.1128/IAI.05644-11.
Epub 2011 Aug 29. PMID: 21875962; PMCID: PMC3257940.
35: Trappetti C, Ogunniyi AD, Oggioni MR, Paton JC. Extracellular matrix
formation enhances the ability of Streptococcus pneumoniae to cause invasive
disease. PLoS One. 2011;6(5):e19844. doi: 10.1371/journal.pone.0019844. Epub
2011 May 18. PMID: 21611130; PMCID: PMC3097209.
36: Trappetti C, Gualdi L, Di Meola L, Jain P, Korir CC, Edmonds P, Iannelli F,
Ricci S, Pozzi G, Oggioni MR. The impact of the competence quorum sensing system
on Streptococcus pneumoniae biofilms varies depending on the experimental model.
BMC Microbiol. 2011 Apr 14;11:75. doi: 10.1186/1471-2180-11-75. PMID: 21492426;
PMCID: PMC3098770.
37: Trappetti C, Kadioglu A, Carter M, Hayre J, Iannelli F, Pozzi G, Andrew PW,
Oggioni MR. Sialic acid: a preventable signal for pneumococcal biofilm
formation, colonization, and invasion of the host. J Infect Dis. 2009 May
15;199(10):1497-505. doi: 10.1086/598483. PMID: 19392624.
38: Oggioni MR, Trappetti C, Kadioglu A, Cassone M, Iannelli F, Ricci S, Andrew
PW, Pozzi G. Switch from planktonic to sessile life: a major event in
pneumococcal pathogenesis. Mol Microbiol. 2006 Sep;61(5):1196-210. doi:
10.1111/j.1365-2958.2006.05310.x. PMID: 16925554; PMCID: PMC1618759.
39: Isola D, Pardini M, Varaine F, Niemann S, Rüsch-Gerdes S, Fattorini L,
Orefici G, Meacci F, Trappetti C, Rinaldo Oggioni M, Orrù G; LONG-DRUG study
group. A Pyrosequencing assay for rapid recognition of SNPs in Mycobacterium
tuberculosis embB306 region. J Microbiol Methods. 2005 Jul;62(1):113-20. doi:
10.1016/j.mimet.2005.02.004. PMID: 15823399.
40: Oggioni MR, Iannelli F, Ricci S, Chiavolini D, Parigi R, Trappetti C,
Claverys JP, Pozzi G. Antibacterial activity of a competence-stimulating peptide
in experimental sepsis caused by Streptococcus pneumoniae. Antimicrob Agents
Chemother. 2004 Dec;48(12):4725-32. doi: 10.1128/AAC.48.12.4725-4732.2004. PMID:
15561850; PMCID: PMC529211.
